[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583591":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":7,"locations":7,"responsibleParty":8,"collaborators":7,"id":12,"slug":13,"hasResults":14,"nctId":15,"briefTitle":16,"officialTitle":16,"acronym":7,"eligibilityCriteria":17,"healthyVolunteers":14,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":24,"studyType":25,"phases":7,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":7,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":7},{"fullName":5,"class":6},"Hospital El Cruce","OTHER",null,{"type":9,"investigatorFullName":10,"investigatorTitle":11,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Nestor Pistillo","Head of intensive care","100583591","role-of-elastic-power-in-acute-respiratory-distress-syndrome-100583591",false,"NCT06878313","Role of Elastic Power in Acute Respiratory Distress Syndrome","Inclusion Criteria: Adult patients (≥18 years) with moderate-to-severe acute respiratory distress syndrome (ARDS), as defined by the Berlin criteria, were prospectively and consecutively included.\n\n\\-\n\nExclusion Criteria: Patients were excluded if they met at least one of the following criteria:\n\n* History of emphysema, asthma, or pneumothorax.\n* Severe instability at the time of the study preventing the PEEP titration maneuver, defined by at least one of the following indicators: SaO₂ ≤ 90%, shock requiring \\>0.5 γ\u002Fkg\u002Fmin of norepinephrine, complex arrhythmia, myocardial ischemia, or intracranial hypertension refractory to initial treatment.\n* Patients with do-not-resuscitate orders and pregnant women.","ALL","18 Years","80 Years",{"count":22,"type":23},20,"ESTIMATED","28 Days","OBSERVATIONAL","Mechanical ventilation is essential for managing acute respiratory distress syndrome (ARDS), but it can also cause ventilator-induced lung injury (VILI) due to mechanical forces. VILI results from the interaction between lung structure and mechanical ventilation factors, such as tidal volume, plateau pressure, driving pressure, inspiratory flow, respiratory rate, and PEEP. Intrinsic factors like lung heterogeneity further increase the risk.\n\nElastic power (EP), a key component, is linked to repetitive alveolar stretching and disease progression.\n\nStudy Objectives:\n\nExamine the correlation between elastic power and pulmonary hyperinflation. Compare EP's sensitivity and specificity with other overdistension markers like driving pressure, plateau pressure, upper inflection point, and compliance.",[28,29],"ARDS (Moderate or Severe)","Adult Patients",[31,32,33],"ARDS","VILI","Mechanical Ventilation","NOT_YET_RECRUITING","2025-03-11",{"date":37,"type":38},"2025-03-14","ACTUAL",{"date":40,"type":23},"2025-04-01",{"date":42,"type":23},"2026-07-01",{"name":5,"class":6}]