[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610486":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":26,"locations":34,"responsibleParty":52,"collaborators":26,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":26,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":26,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":26,"overallStatus":75,"whyStopped":26,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Medical College of Wisconsin","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Antioxidant Supplementation","EXPERIMENTAL","MitoQ, a mitochondrial target antioxidant, given once at a dose of 160 mg",[13],"Dietary Supplement: MitoQ (mitoquinol mesylate)",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","A placebo similar visually will be used to compare to MitoQ",[19],"Dietary Supplement: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","MitoQ (mitoquinol mesylate)","During each testing session, the investigators will be measuring how one treatment of an over-the-counter antioxidant supplement affects blood flow and muscle function. One day participants will orally ingest an over-the-counter antioxidant supplement called MitoQ.",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"During each testing session, the investigators will be measuring how one treatment of an over-the-counter antioxidant supplement affects blood flow and muscle function. One day participants will orally ingest an over-the-counter antioxidant supplement called MitoQ, while the other they will ingest a placebo",[15],[31],{"name":32,"affiliation":5,"role":33},"William E Hughes, Ph.D.","PRINCIPAL_INVESTIGATOR",[35],{"facility":5,"status":26,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Milwaukee","Wisconsin","53226","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-87.90647,43.0389,{"lat":45,"lon":44},[48],{"name":32,"role":49,"phone":26,"phoneExt":50,"email":51},"CONTACT","414-955-7519","whughes@mcw.edu",{"type":33,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"William Hughes","Assistant Professor","100610486","role-of-endothelial-dysfunction-on-exercise-pressor-reflex-in-type-2-diabetes-100610486",false,"NCT07228208","Role of Endothelial Dysfunction on Exercise Pressor Reflex in Type 2 Diabetes","Inclusion Criteria:\n\n* Type 2 Diabetes: 18 - 80 years old, able to give informed consent, \\> 6 months post-diagnosis, \\> 6 months stable medications for management\n* Healthy controls: 18 - 80 years old, able to give informed consent\n\nExclusion Criteria:\n\n* Type 2 Diabetes: Type 1 diabetes, symptomatic coronary artery disease, cardiovascular event in last year (MI, stroke), uncontrolled or unmanaged hypertension (\\>160\u002F90 mmHg), heart failure, renal impairments, current or recent (\\\u003C6 months) tobacco use, hormone replacement therapy, documented neuromuscular disorders, pregnancy\n* Healthy Controls: Same as listed in Type 2 Diabetes with Type 2 Diabetes as an exclusion factor",true,"ALL","18 Years","80 Years",{"count":66,"type":67},40,"ESTIMATED","INTERVENTIONAL",[70],"NA","Exaggerated blood pressure responses to exercise in individuals with Type 2 Diabetes significantly increase the risk of heart attack, stroke, and cardiovascular death, while also limiting exercise capacity and therapeutic benefits of physical activity. This research will determine whether impaired blood vessel function and excessive cellular damage from oxygen-containing molecules cause these dangerous blood pressure responses during exercise. The findings will establish whether targeting cellular antioxidant systems represents a new therapeutic approach to improve exercise tolerance and reduce cardiovascular risk in t Americans living with diabetes.",[73,74],"Type 2 Diabetes (T2DM)","Endothelial Dysfunction","NOT_YET_RECRUITING","2025-11-12",{"date":78,"type":79},"2025-11-14","ACTUAL",{"date":81,"type":67},"2026-09-01",{"date":83,"type":67},"2031-12-31",{"name":5,"class":6},1]