[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587491":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":35,"centralContacts":43,"locations":53,"responsibleParty":73,"collaborators":23,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":23,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":23,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":106,"whyStopped":23,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Combined Military Hospital Bahawalpur","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"5cm of water Positive End-expiratory Pressure will be applied after induction of general anesthesia","PLACEBO_COMPARATOR","A fixed positive end-expiratory pressure of 5cm of water will administered to the participants after induction of general anesthesia during mechanical ventilation undergoing laparoscopic surgeries.",[13],"Other: Protective lung ventilation methods with different positive end-expiratory pressure during Laparoscopic Surgeries",{"label":15,"type":16,"description":17,"interventionNames":18},"Individualized PEEP with recruitment maneuver guided by driving pressure measurement","EXPERIMENTAL","Recruitment maneuver will be applied after induction of general anesthesia and indiviualized positive end-expiratory pressure will be applied guided by driving pressue during mechanical ventilation during laparoscopic surgeries.",[13],{"label":20,"type":21,"description":22,"interventionNames":23},"Conventional ventilation","NO_INTERVENTION","Conventional ventilation method without additional positive end-expiratory pressure will be applied to participants during mechanical ventilation undergoing laparoscopic surgeries.",null,[25],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"Protective lung ventilation methods with different positive end-expiratory pressure during Laparoscopic Surgeries","Protective lung ventilation methods with positive end-expiratory pressure help in prevention of atelectasis and improvement of intraoperative ventilator parameters e.g low driving pressure and improved dynamic compliance resulting in better oxygenation of lungs ere will be three groups in this study. Individualized positive end-expiratory pressure with recruitment maneuver and fixed positive end-expiratory pressure will be interventional groups. They will be compared with conventional ventilation group in which no additional positive end-expiratory pressure will be applied. The effects on respiratory parameters and oxygenation of patients will be compared for each group. This study will determine which method of positive end-expiratory pressure is superior and how it differs from conventional ventilation for prevention of atelectasis induced by pneumoperitonium and improvement of respiratory mechanical parameters and oxygenation in Mechanical ventilation during laparoscopic surgeries.",[9,15],[30,31,32,33,34],"Application of possitive end expiratory pressure during laparoscopic surgeries","Individual PEEP with recruitment maneuver","Fixed PEEP","Protective lung ventilation","Different positive end-expiratory pressure strategies",[36,40],{"name":37,"affiliation":38,"role":39},"Colonal Naseem Abbas","Head of Department of Anesthesia Combined Military Hospital Bahawalpur","PRINCIPAL_INVESTIGATOR",{"name":41,"affiliation":42,"role":39},"Dr Noor-Ul-Ain Registrar Anesthesia","Department of Anesthesia Combined Military Hospital Bahawalpur",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":23,"email":48},"Dr. Noor-Ul-Ain, MBBS","CONTACT","+92332-6594515","noorulain0145@gmail.com",{"name":50,"role":46,"phone":51,"phoneExt":23,"email":52},"Dr Smavia Aslam, MBBS","+92312-7125450","smaviaaslam555@gmail.com",[54],{"facility":5,"status":23,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Bahawalpur","Punjab Province","63100","Pakistan","PK",{"type":61,"coordinates":62},"Point",[63,64],71.6752,29.39779,{"lat":64,"lon":63},[67,69,71],{"name":68,"role":46,"phone":47,"phoneExt":23,"email":48},"Dr. Noor-Ul-Ain Registrar Anesthesia, MBBS",{"name":70,"role":39,"phone":23,"phoneExt":23,"email":23},"Dr Noor-Ul-Ain Registrar Anesthesia, MBBS",{"name":72,"role":39,"phone":23,"phoneExt":23,"email":23},"Colonal Naseem Abbas, FCPS Anesthesiology",{"type":74,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"SPONSOR_INVESTIGATOR","Noor-Ul-Ain","Post Graduate Resident Anesthesiology Fellowship of College of Physicians and Surgeons Pakistan","100587491","role-of-individualized-peep-vs-fixed-peep-in-mechanical-ventilation-during-laparoscopic-surgeries-100587491",false,"NCT06929078","Role of Individualized PEEP Vs Fixed PEEP in Mechanical Ventilation During Laparoscopic Surgeries","Role of Individualized Positive End-expiratory Pressure Versus Fixed Positive End-expiratory Pressure in Mechanical Ventilation During Laparoscopic Surgeries","Inclusion Criteria:\n\n* 1\\. Age Limit : 25 years to 65 years\n\n  2\\. Patients undergoing laparoscopic suregeries\n\n  3\\. ASA 1-3\n\nExclusion Criteria:\n\n* 1\\. Hemodynamic instability 2. Bronchospam 3. Patients having COPD 4. History of pulmonary bulla 5. Patients having history of pneumothora",true,"ALL","25 Years","65 Years",{"count":89,"type":90},75,"ESTIMATED","INTERVENTIONAL",[93],"NA","To compare the effects of Individualized positive end-expiratory pressure with recruitment maneuver on respiratory parameters and oxygenation in mechanical ventilation during laparoscopic surgeries with the fixed positive end-expiratory pressure and conventional mechanical ventilation without positive end-expiratory pressure.",[96,97,98],"Laparoscopic Surgery","Pneumoperitoneum","Positive End Expiratory Pressure (PEEP)",[100,101,102,103,104,105],"mechanical ventilation","lung compliance","positive end-expiratory pressure","respiratory mechanics","oxygenation index","driving pressure","NOT_YET_RECRUITING","2025-04-08",{"date":109,"type":110},"2025-04-16","ACTUAL",{"date":112,"type":90},"2025-05",{"date":114,"type":90},"2025-11",{"name":75,"class":6},1]