[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571269":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":17,"responsibleParty":33,"collaborators":7,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":39,"acronym":7,"eligibilityCriteria":40,"healthyVolunteers":37,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":7,"studyType":47,"phases":7,"briefSummary":48,"conditions":49,"keywords":51,"overallStatus":53,"whyStopped":7,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":63},{"fullName":5,"class":6},"IRCCS Azienda Ospedaliero-Universitaria di Bologna","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Angela Miniaci, MD","PRINCIPAL_INVESTIGATOR",[13],{"name":10,"role":14,"phone":15,"phoneExt":7,"email":16},"CONTACT","00390512144811","angela.miniaci@aosp.bo.it",[18],{"facility":5,"status":7,"city":19,"state":19,"zip":20,"country":21,"countryCode":22,"cosmosGeoPoint":23,"geoPoint":28,"contacts":29},"Bologna","40138","Italy","IT",{"type":24,"coordinates":25},"Point",[26,27],11.33875,44.49381,{"lat":27,"lon":26},[30,31],{"name":10,"role":14,"phone":15,"phoneExt":7,"email":16},{"name":32,"role":11,"phone":7,"phoneExt":7,"email":7},"Angela Miniaci",{"type":11,"investigatorFullName":32,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"MD","100571269","role-of-interleukin-18-il-18-and-interleukin-18-binding-protein-il-18bp-in-the-diagnostic-work-up-of-systemic-juvenile-idiopathic-arthritis-and-autoinflammatory-diseases-possible-biomarkers-in-the-differential-diagnosis-of-other-febrile-diseases-100571269",false,"NCT06718049","Role of Interleukin 18 (IL-18) and Interleukin 18 Binding Protein (IL-18BP) in the Diagnostic Work-up of Systemic Juvenile Idiopathic Arthritis and Autoinflammatory Diseases: Possible Biomarkers in the Differential Diagnosis of Other Febrile Diseases","Inclusion Criteria:\n\n* Age between 2 years and 18 years;\n* Being affected by 1 of the following: Juvenile Idiopathic Arthritis; recurrent fever\u002F autoinflammatory disease; rheumatic disease; severe infectious diseases (sepsis, meningitis, urinary tract infection, lower respiratory tract infection);\n* Obtaining informed consent from parents\u002Flegal guardians of paediatric patients.\n\nExclusion Criteria:\n\n• Patients in whom the suspicion of rheumatic disease is based on a finding of subclinical carditis or chorea.","ALL","2 Years","18 Years",{"count":45,"type":46},9,"ESTIMATED","OBSERVATIONAL","Literature data suggest that elevated blood values of IL-18 and IL-18 Binding Protein and alterations in their ratio may be significantly correlated with various autoinflammatory diseases, such as systemic juvenile idiopathic arthritis, recurrent autoinflammatory fevers etc. In this view, the clinical implication of this observational, prospective, single-centre, non-pharmacological study will be the definition of new laboratory markers that may be useful in the early differential diagnosis of certain rare and serious paediatric diseases.",[50],"Systemic Juvenile Idiopathic Arthritis (sJIA)",[52],"Systemic Juvenile Idiopathic Arthritis","NOT_YET_RECRUITING","2026-03-11",{"date":56,"type":57},"2026-03-12","ACTUAL",{"date":59,"type":46},"2027-01-01",{"date":61,"type":46},"2027-12-31",{"name":5,"class":6},1]