[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100423247":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":25,"locations":31,"responsibleParty":78,"collaborators":80,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":24,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":24,"overallStatus":34,"whyStopped":24,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"University of Colorado, Denver","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Type 2 Diabetes","EXPERIMENTAL","Participants aged 30-55 with type 2 diabetes",[13],"Behavioral: Cardiovascular exercise",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy overweight control","Participants aged 30-55 with BMI 25-40 without type 2 diabetes",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Cardiovascular exercise","15 weeks of cardiovascular exercise 3x\u002Fweek for 50 minutes\u002Fsession",[15,9],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},"Benjamin Juckett, MS","CONTACT","303-724-1338","benjamin.juckett@cuanschutz.edu",[32,57],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"University of Colorado","RECRUITING","Aurora","Colorado","80045","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-104.83192,39.72943,{"lat":44,"lon":43},[47,48,52,55],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},{"name":49,"role":28,"phone":50,"phoneExt":24,"email":51},"Ethan Clark, MS","303-724-1354","ethan.w.clark@cuanschutz.edu",{"name":53,"role":54,"phone":24,"phoneExt":24,"email":24},"Judy Regensteiner, PhD","PRINCIPAL_INVESTIGATOR",{"name":56,"role":54,"phone":24,"phoneExt":24,"email":24},"Jane Reusch, MD",{"facility":58,"status":34,"city":59,"state":60,"zip":61,"country":38,"countryCode":39,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"University of Virginia","Charlottesville","Virginia","22908",{"type":41,"coordinates":63},[64,65],-78.47668,38.02931,{"lat":65,"lon":64},[68,72,76],{"name":69,"role":28,"phone":70,"phoneExt":24,"email":71},"Lee Hartline, MEd","434-924-5247","lmh9d@virginia.edu",{"name":73,"role":28,"phone":74,"phoneExt":24,"email":75},"Linda Jahn, RN","434-924-1134","las6e@virginia.edu",{"name":77,"role":54,"phone":24,"phoneExt":24,"email":24},"Zhenqi Liu, MD",{"type":79,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[81,82],{"name":58,"class":6},{"name":83,"class":84},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100423247","role-of-microvascular-insulin-resistance-and-cardiorespiratory-fitness-diabetes-100423247",false,"NCT04791371","Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes","REACH","Inclusion Criteria:\n\n* Sedentary (defined as less than 1 hour per week of physical activity)\n* BMI: 25-40\n* Men and women with and without type 2 diabetes\n\nExclusion Criteria:\n\n* Documented cardiovascular disease\n* Uncontrolled hypertension: disease systolic blood pressure (SBP) \\> 150, diastolic blood pressure (DBP)\\> 110\n* Obstructive pulmonary disease or asthma\n* Peripheral neuropathy\n* Physical impairment that would limit exercise ability\n* Subjects taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)\n* Current or past smoking within the last 1 years\n* Current tobacco use\n* Anemia\n* Control HbA1c \\> 5.7, T2DM HbA1c \\> 9\n* Pregnant, nursing or hormonal therapy (other than contraceptives)\n* Peri or post-menopausal women\n* Type 1 diabetes\n* Hepatic or renal disease.",true,"ALL","30 Years","55 Years",{"count":97,"type":98},150,"ESTIMATED","INTERVENTIONAL",[101],"NA","The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.",[9,104],"Overweight and Obesity","2026-03-19",{"date":107,"type":108},"2026-03-23","ACTUAL",{"date":110,"type":108},"2022-06-17",{"date":112,"type":98},"2027-02-15",{"name":5,"class":6},2]