[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584611":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":18,"locations":24,"responsibleParty":36,"collaborators":10,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":40,"sex":46,"minAge":47,"maxAge":10,"enrollmentInfo":48,"targetDuration":10,"studyType":51,"phases":10,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":26,"whyStopped":10,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"Region Stockholm","OTHER_GOV",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Trauma",null,"Trauma alarm activated at hospital admission New Injury Severity Score (NISS) \\> 15 Transfer to hospital within 7 days of trauma with NISS \\> 15",{"label":13,"type":10,"description":14,"interventionNames":10},"Sepsis","Meeting Sepsis-3 criteria Receipt of intravenous beta-lactam or aminoglycoside antibiotics within 48 hours of admission",{"label":16,"type":10,"description":17,"interventionNames":10},"Control","Patients undergoing elective surgery without expected coagulopathy",[19],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Mattias Günther, MD PhD","CONTACT","+46812361000","mattias.gunther@regionstockholm.se",[25],{"facility":5,"status":26,"city":27,"state":10,"zip":10,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":10},"RECRUITING","Stockholm","Sweden","SE",{"type":31,"coordinates":32},"Point",[33,34],18.06871,59.32938,{"lat":34,"lon":33},{"type":37,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100584611","rotem-in-sepsis-trauma-outcome-in-intensive-care-100584611",false,"NCT06891599","ROTEM in Sepsis Trauma Outcome in Intensive Care","Advanced Coagulation Diagnostics Using ROTEM and Standard Coagulation Tests in Hospitalized Patients With Sepsis or Trauma - A Prospective Observational Study (ROSTIC - ROTEM for Sepsis and Trauma Induced Coagulopathy)","ROSTIC","Inclusion Criteria:\n\nTrauma patients:\n\nTrauma alarm activated at hospital admission New Injury Severity Score (NISS) \\> 15 Transfer to hospital within 7 days of trauma with NISS \\> 15\n\nSepsis patients:\n\nMeeting Sepsis-3 criteria Receipt of intravenous beta-lactam or aminoglycoside antibiotics within 48 hours of admission\n\nControl group:\n\nPatients undergoing elective surgery without expected coagulopathy\n\nExclusion Criteria:\n\nTrauma patients:\n\nIsolated chronic subdural hematoma No underlying traumatic event despite trauma alarm Age \\\u003C18 years\n\nSepsis patients:\n\nAge \\\u003C18 years\n\nControl patients:\n\nOngoing anticoagulant treatment Life-threatening illness (ASA IV-V) Age \\\u003C18 years","ALL","18 Years",{"count":49,"type":50},600,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to investigate the ability of advanced ROTEM analysis using Principal Component Analysis (PCA) to detect early signs of disseminated intravascular coagulation (DIC) and trauma-induced coagulopathy (TIC) in hospitalized patients with sepsis or trauma. Standard coagulation tests and ROTEM measurements will be collected and analyzed in relation to clinical outcomes.",[54,55],"Sepsis - to Reduce Mortality in the Intensive Care Unit","Trauma Coagulopathy",[13,57,9,58],"ROTEM","Coagulopathy","2025-03-20",{"date":61,"type":62},"2025-03-24","ACTUAL",{"date":64,"type":62},"2024-11-01",{"date":66,"type":50},"2026-12-31",{"name":5,"class":6},1]