[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548924":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":21,"responsibleParty":38,"collaborators":7,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":42,"sex":48,"minAge":49,"maxAge":7,"enrollmentInfo":50,"targetDuration":7,"studyType":53,"phases":7,"briefSummary":54,"conditions":55,"keywords":7,"overallStatus":24,"whyStopped":7,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},{"fullName":5,"class":6},"Imperial College London","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Alison Holmes, MD","PRINCIPAL_INVESTIGATOR",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Suzy Williams","CONTACT","+44 (0) 20 3313 2732","suzanne.williams@imperial.ac.uk",{"name":19,"role":15,"phone":7,"phoneExt":7,"email":20},"Richard Wilson, MPharm","richard.wilson@imperial.ac.uk",[22],{"facility":23,"status":24,"city":25,"state":7,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Imperial College Healthcare NHS Trust","RECRUITING","London","W12 0HS","United Kingdom","UK",{"type":30,"coordinates":31},"Point",[32,33],-0.12574,51.50853,{"lat":33,"lon":32},[36],{"name":14,"role":15,"phone":37,"phoneExt":7,"email":17},"+44 (0)20 3313 2732",{"type":39,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100548924","routinely-collected-clinical-data-and-evaluation-of-antimicrobial-target-attainment-100548924",false,"NCT06427317","Routinely Collected Clinical Data and Evaluation of Antimicrobial Target Attainment","Routinely Collected Clinical Data and Evaluation of Antimicrobial Target Attainment and the Potential Role of Therapeutic Drug Monitoring in UK Infection Management","DATATDM","Inclusion Criteria:\n\n18 years of age or above.\n\n* Under follow-up for management of infection at Imperial College NHS Trust\n* Received a beta-lactam antibiotic within the last 48 hours (or are planned to start imminently).\n* Provides informed written consent see below, or lacks capacity to provide consent because of one of the following conditions (and declaration provided by personal consultee):\n* Delirium which may be caused or exacerbated by having an infection.\n* Suspected\u002Fconfirmed central nervous system infection.\n* Critical illness requiring sedation and\u002For intubation and ventilation which is caused by or exacerbated by having an infection.\n\nExclusion Criteria:\n\n* Less than 18 years of age\n\n  * Severe anaemia (Hb \\\u003C 70g\u002Fl)\n  * Platelets \\\u003C 50x10\\^9\u002Fl, INR \\>1.5 or other known blood clotting impairment\n  * Patient with terminal diagnosis receiving palliative care input who may experience distress if approached for this study.\n  * Enrolled in a clinical trial which stipulates exclusion from other studies including observational studies.\n  * Patients with restricted liberty, prisoners or under legal protection.","ALL","18 Years",{"count":51,"type":52},323,"ESTIMATED","OBSERVATIONAL","The primary aim of the study is to determine the proportion of individuals receiving beta-lactam antibiotics at Imperial College Healthcare NHS Trust in whom drug concentration targets are achieved.",[56,57,58,59],"Infections, Bacterial","Pharmacokinetics","Drug Monitoring","Drug-Related Side Effects and Adverse Reactions","2024-05-21",{"date":62,"type":63},"2024-05-23","ACTUAL",{"date":65,"type":63},"2024-03-19",{"date":67,"type":52},"2027-03-19",{"name":5,"class":6},1]