[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607163":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":37,"centralContacts":41,"locations":51,"responsibleParty":64,"collaborators":66,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":27,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":27,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":53,"whyStopped":27,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"NYU Langone Health","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Active tDCS","EXPERIMENTAL","Participants will complete 20 remotely supervised (RS) daily sessions, each 20 minutes, of active dorsolateral prefrontal cortex (DLPFC) tDCS combined with mindfulness meditation.",[13,14],"Device: Active Transcranial Direct Current Stimulation (tDCS)","Behavioral: Mindfulness meditation",{"label":16,"type":17,"description":18,"interventionNames":19},"Sham tDCS","ACTIVE_COMPARATOR","Participants will complete 20 RS sham sessions, each 20 minutes, of active DLPFC tDCS combined with mindfulness meditation.",[20,14],"Device: Sham Transcranial Direct Current Stimulation (tDCS)",[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DEVICE","Active Transcranial Direct Current Stimulation (tDCS)","tDCS is a noninvasive brain stimulation device that modulates brain activity by delivering low-intensity electrical current (2.0 mA) through scalp sponge electrodes. Device is programmed to ramp up to 2.0 mA (for 30 seconds), provide constant current throughout the session (19 minutes), and then ramp down (for 30 seconds) at the end.",[9],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Sham Transcranial Direct Current Stimulation (tDCS)","tDCS is a noninvasive brain stimulation device that modulates brain activity by delivering low-intensity electrical current (2.0 mA) through scalp sponge electrodes. Device is programmed to ramp up to 2.0 mA (for 30 seconds) followed by a ramp down (30 seconds), with no current delivery for 18 minutes, and then ramp up (for 30 seconds) and down (for 30 seconds) at the end.",[16],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":27},"BEHAVIORAL","Mindfulness meditation","Participants will follow an audio track for guided mindfulness during the stimulation.",[9,16],[38],{"name":39,"affiliation":5,"role":40},"Leigh Charvet, PhD","PRINCIPAL_INVESTIGATOR",[42,47],{"name":43,"role":44,"phone":45,"phoneExt":27,"email":46},"Shayna Pehel","CONTACT","929-455-5104","Shayna.Pehel@nyulangone.org",{"name":48,"role":44,"phone":49,"phoneExt":27,"email":50},"Giuseppina Pilloni","929-455-5317","Giuseppina.Pilloni@nyulangone.org",[52],{"facility":5,"status":53,"city":54,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":27},"RECRUITING","New York","10016","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-74.00597,40.71427,{"lat":62,"lon":61},{"type":65,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR",[67],{"name":68,"class":69},"National Institute on Drug Abuse (NIDA)","NIH","100607163","rs-tdcs-for-cannabis-use-disorder-the-cares-initiative-100607163",false,"NCT07184983","RS-tDCS for Cannabis Use Disorder: The C.A.R.E.S. Initiative","Telehealth-Delivered tDCS for Cannabis Addiction Recovery: The C.A.R.E.S. (Cannabis Addiction Recovery Enhancement Stimulation) Initiative","Inclusion Criteria:\n\n1. Aged 22-65 years (inclusive)\n2. Currently meets the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) criteria for CUD, as determined by DSM-V criteria (M.I.N.I)\n3. Positive for cannabis on the 11-COOH-THC single panel urine test\n4. Seeking treatment to reduce or discontinue cannabis use (Marijuana Ladder ranged between 5-8 \\[inclusive\\])\n5. Kessler Psychological Distress Scale (K10) score \\\u003C 35 (minimal to moderate distress)\n6. Wide Range Achievement Test-5(WRAT-5) score ≥ 85\n7. Ability to use mobile devices\n8. Fluent in English or Spanish\n\nExclusion Criteria:\n\n1. Cannabis is used exclusively as prescribed or directed by their provider\n2. Meets DSM-V criteria for substance use disorder within the past six months for any psychoactive substance other than cannabis\n3. Meets DSM-V criteria for alcohol use disorder within the past six months\n4. Primary psychiatric disorder (major depressive disorder, bipolar disorder, or psychotic disorder) as the principal diagnosis, independent of cannabis use disorder; or current diagnosis of bipolar disorder, psychotic disorder, or any other alcohol\u002Fsubstance use disorder as defined by DSM-5-TR and confirmed via the Mini-International Neuropsychiatric Interview (MINI).\n5. Primary neurologic or major medical disorder that would interfere with study participation.\n6. Enrolled in group or individual therapy for substance use disorder that would be concurrent with the study intervention\n7. History of moderate or severe traumatic brain injury\n8. Seizure disorder or recent (\\\u003C5 years) seizure history\n9. Presence of metal or active implants in the head\u002Fneck\n10. Any skin disorder or skin sensitive area near stimulation locations\n11. Pregnant or planning pregnancy during the study period or breastfeeding","ALL","22 Years","65 Years",{"count":81,"type":82},46,"ESTIMATED","INTERVENTIONAL",[85],"NA","The purpose of this sham-controlled pilot randomized controlled trial (RCT) is to evaluate the feasibility, safety, and preliminary efficacy of a one-month intervention consisting of 20 home-based active or sham RS-tDCS sessions paired with audio track guided mindfulness meditation practice in otherwise healthy adults seeking to reduce cannabis use in the context of cannabis use disorder (CUD).",[88],"Cannabis Use Disorder",[90,91,92,93,94,95],"Cannabis","CUD","tDCS","Transcranial Direct Current Stimulation","Neuromodulation","Brain Stimulation","2026-04-16",{"date":98,"type":99},"2026-04-21","ACTUAL",{"date":101,"type":99},"2025-11-12",{"date":103,"type":82},"2026-10-01",{"name":5,"class":6},1]