[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100559952":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":39,"centralContacts":44,"locations":50,"responsibleParty":67,"collaborators":34,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":34,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":53,"whyStopped":34,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Danish Research Centre for Magnetic Resonance","OTHER",[8,14,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Gamma burst rTMS","ACTIVE_COMPARATOR","Real stimulation with 4 pulses at the frequency of 130Hz repeating at 1 Hz will be delivered on the pre-SMA using the active side of the coil for 30 minutes",[13],"Device: active TMS",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham gamma burts rTMS","SHAM_COMPARATOR","Sham stimulation with 4 pulses at the frequency of 130Hz repeating at 1Hz will be delivered on the pre-SMA with a non-active side of the coil for 30 minutes",[19],"Device: sham TMS",{"label":21,"type":10,"description":22,"interventionNames":23},"Beta burst rTMS","Real stimulation with 4 pulses at the frequency of 20Hz repeating at 1 Hz be delivered on the pre-SMA using the active side of the coil for 30 minutes",[13],{"label":25,"type":16,"description":26,"interventionNames":27},"Sham beta burst rTMS","Sham stimulation with 4 pulses at the frequency of 20Hz repeating at 1Hz will be delivered on the pre-SMA with a non-active side of the coil for 30 minutes",[19],[29,35],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DEVICE","active TMS","Transcranial magnetic stimulation using MagVenture XP Orange Stimulator using active side of MagVenture Cool-B70 coil",[21,9],null,{"type":30,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"sham TMS","Sham transcranial magnetic stimulation using MagVenture XP Orange Stimulator, flipping the active side of the MagVenture Cool-B70 coil",[25,15],[40],{"name":41,"affiliation":42,"role":43},"Hartwig R. Siebner, Prof.","Head of Research, Prof, DMSc","PRINCIPAL_INVESTIGATOR",[45],{"name":46,"role":47,"phone":48,"phoneExt":34,"email":49},"Laura Sakalauskaite, MD","CONTACT","+45 38621184","laura.sakalauskaite.01@regionh.dk",[51],{"facility":52,"status":53,"city":54,"state":34,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"DRCMR","RECRUITING","Hvidovre","2650","Denmark","DK",{"type":59,"coordinates":60},"Point",[61,62],12.47708,55.64297,{"lat":62,"lon":61},[65],{"name":66,"role":47,"phone":34,"phoneExt":34,"email":34},"Hartwig Siebner, Prof",{"type":43,"investigatorFullName":68,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"Hartwig R. Siebner","100559952","rtms-as-an-intervention-for-levodopa-induced-dyskinesia-100559952",false,"NCT06570824","rTMS as an Intervention for Levodopa-induced Dyskinesia","Network Based Repetitive Transcranial Magnetic Stimulation (rTMS) as an Intervention for Levodopa-induced Dyskinesia (LID) in Parkinson's Disease (PD)","ADAPT-LIDI","Inclusion Criteria:\n\n* Clinically established or probable PD\n* Clinical Diagnostic Criteria for Parkinson's Disease\n* Peak-of-dose levodopa-induced dyskinesia.\n* Stable antiparkinsonian medicine for at least four weeks.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Psychiatric disorders.\n* Usage of antipsychotic medication, Donepezil, and GABAergic medications (such as pregabalin and gabapentin).\n* Regular usage of benzodiazepines and opioids (more than once per week).\n* History of neurological disease other than Parkinson's disease.\n* History of epilepsy\u002Fconditions associated with increased risk to seizure-induction through TMS.\n* Close relatives suffering from epilepsy\u002Fconditions associated with increased risk to seizure-induction through TMS.\n* Contraindications for MRI scan\n* Female participants of childbearing age must not be pregnant and that they must use contraception during the trial.\n* Refuse to be informed about new health related information and accidental health related findings that might appear through participation in the study.","ALL","18 Years","80 Years",{"count":81,"type":82},68,"ESTIMATED","INTERVENTIONAL",[85],"NA","The proposed study investigates the use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for levodopa-induced dyskinesia (LID) in Parkinson's Disease (PD). Specifically, the study aims to determine whether patterned stimulation of the pre-supplementary motor area (pre-SMA) can delay the onset of LID after levodopa intake and reduce LID severity in PD patients. This study will provide critical insights into potential targets for rTMS treatment, optimal rTMS parameters, and the mechanisms underlying LID in Parkinson's disease.",[88,89],"Dyskinesia, Drug-Induced","Parkinson Disease",[91,92,93,94,95,96,97,98,99,100],"Basal Ganglia Diseases","Parkinson's Disease","Central Nervous System Diseases","Movement Disorders","Synucleinopathies","Neurodegenerative Diseases","Dyskinesias","LID","Levodopa induced dyskinesia","Pre-SMA","2024-08-26",{"date":103,"type":104},"2024-08-28","ACTUAL",{"date":106,"type":104},"2024-07-22",{"date":108,"type":82},"2027-05-01",{"name":5,"class":6},1]