[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596852":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":38,"locations":48,"responsibleParty":66,"collaborators":32,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":32,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":32,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":91,"whyStopped":32,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Deep rTMS","ACTIVE_COMPARATOR","DThe first group will receive 10 Hz DTMS (standard TMS) with a protocol of 3 seconds on, 15 seconds off, and a total of 1800 pulses\u002Fsession, lasting 18 minutes, targeting the bilateral insula and lateral prefrontal cortex.",[13],"Device: Transcranial Magnetic Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Precision TMS","EXPERIMENTAL","The other group will receive 10 Hz personalized-image-guided and Efield-modeling dose rTMS (precision TMS) with a protocol of 5 seconds on, 10 seconds off, and a total of 3000 pulses\u002Fsession, lasting 15 minutes, targeting the left DLPFC.",[19],"Device: personalized-image-guided and E-field-modeling dose rTMS (precision TMS)",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Transcranial Magnetic Stimulation","The first group will receive 10 Hz DTMS (standard TMS) with a protocol of 3 seconds on, 15 seconds off, and a total of 1800 pulses\u002Fsession, lasting 18 minutes, targeting the bilateral insula and lateral prefrontal cortex.",[9],[27],"Deep TMS, Standard rTMS",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"personalized-image-guided and E-field-modeling dose rTMS (precision TMS)","with a protocol of 5 seconds on, 10 seconds off, and a total of 3000 pulses\u002Fsession, lasting 15 minutes, targeting the left DLPFC.",[15],null,[34],{"name":35,"affiliation":36,"role":37},"Xingbao Li, MD","Ralph H. Johnson VA Medical Center, Charleston, SC","PRINCIPAL_INVESTIGATOR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":32,"email":43},"R. Amanda C LaRue, PhD","CONTACT","(843) 789-6707","Rutha.Larue@va.gov",{"name":45,"role":41,"phone":46,"phoneExt":32,"email":47},"Sarah A Jackson, BA MA","(843) 789-6700","sarah.jackson@va.gov",[49],{"facility":36,"status":32,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Charleston","South Carolina","29401-5703","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-79.93275,32.77632,{"lat":59,"lon":58},[62,64,65],{"name":40,"role":41,"phone":63,"phoneExt":32,"email":43},"843-789-6707",{"name":45,"role":41,"phone":46,"phoneExt":32,"email":47},{"name":35,"role":37,"phone":32,"phoneExt":32,"email":32},{"type":67,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100596852","rtms-for-tobacco-use-in-veterans-100596852",false,"NCT07050862","rTMS for Tobacco Use in Veterans","Circuity-guided Repetitive Transcranial Magnetic Stimulation (rTMS) for Tobacco Use in Veterans: A Comparison of Insula-rTMS and Prefrontal-rTMS","Inclusion Criteria:\n\n* Veteran\n* Males and females between the ages of 18 and 70\n* Individuals who smoke 10 or more cigarettes per day and have a CO level \\> 10 ppm indicative of recent smoking\n* Those who have not received substance abuse treatment within the previous 30 days\n* Those who have been stable on psychotropic medications for at least three months\n* For females, those who test non-pregnant and use adequate birth control\n* Those who are willing to provide informed consent\n* Those who can comply with protocol requirements and likely complete all study procedures\n* Those who are motivated to quit smoking (based on responses of \"very likely\" or \"somewhat likely\" in the motivation questionnaire\n\nExclusion Criteria:\n\n* Current moderate to severe substance use of any psychoactive substances other than nicotine or caffeine, as defined by DSM-V criteria\n* Contraindications to MRI (e.g., metal in the skull, orbital or intracranial cavity, or claustrophobia)\n* Contraindications to rTMS (history of a seizure or epilepsy)\n* A history of autoimmune, endocrine, viral, or vascular disorders affecting the brain\n* History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment\n* Unstable cardiac disease, uncontrolled hypertension, severe renal or liver insufficiency, or sleep apnea\n* Major Axis I disorders diagnosed according to DSM-V criteria, such as bipolar affective disorder, schizophrenia, dementia, or major depression\n\n  * Regarding the Veteran population, we will enroll smokers who have PTSD\n* Current use of other forms of nicotine delivery, such as nicotine patches or electronic cigarettes\n* Currently prescribed bupropion and\u002For varenicline","ALL","18 Years","70 Years",{"count":79,"type":80},56,"ESTIMATED","INTERVENTIONAL",[83],"NA","Cigarette smoking is a significant public health concern for Veterans. Encouraging smoking cessation continues to be a top priority for the Veterans' Administration as Veterans who use tobacco experience negative health effects, including cancer, heart disease, and mental disorders. Despite the efficacy of current evidence-based pharmacotherapies and psychotherapies for smoking cessation, alternative treatments are critically needed. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive form of brain stimulation, US FDA-approved for smoking cessation. In this protocol, the investigators propose comparing the two rTMS protocols (standard TMS vs. precision TMS) to find a better treatment parameter for smoking cessation in Veterans. Identifying an efficacious rTMS protocol would benefit Veterans who want to quit smoking.",[86,87],"Tabacco Use Disorder","rTMS",[89,90],"Tabacco","substance abuse","NOT_YET_RECRUITING","2026-04-02",{"date":94,"type":95},"2026-04-08","ACTUAL",{"date":97,"type":80},"2026-07-01",{"date":99,"type":80},"2030-08-31",{"name":5,"class":6},1]