[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100431816":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":42,"responsibleParty":68,"collaborators":71,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":25,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":25,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sham rTMS","SHAM_COMPARATOR","Investigators will use electrode stimulation with 10 Hz over DLPFC, total 3000 pulses. The sham-TMS scalp discomfort was matched to that of active TMS. During real TMS there was no current flowing through the scalp electrodes.",[13],"Device: Sham rTMS",{"label":15,"type":16,"description":17,"interventionNames":18},"Active rTMS 10 Hz DLPFC","ACTIVE_COMPARATOR","A stimulation frequency of 10 Hz, pulse train duration (on time) of 5 seconds, inter-train interval (off time) of 10 seconds (15 second cycle time), E-field-modeling to determine TMS intensity and coil orientation, total of 60 trains, session time of 15 minutes, and 3000-total pulses per day, will be delivered over the left DLPFC.",[19],"Device: Active rTMS 10 Hz DLPFC",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Two electrodes on the scalp will be connected to transcutaneous electrical nerve stimulation.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"10 Hz repetitive transcranial magnetic stimulation (rTMS) will be delivered over left dorsolateral prefrontal cortex (DLPFC).",[15],[30],{"name":31,"affiliation":5,"role":32},"Xingbao Li, MD, MSCR, MS","PRINCIPAL_INVESTIGATOR",[34,38],{"name":31,"role":35,"phone":36,"phoneExt":25,"email":37},"CONTACT","843-792-5729","lixi@musc.edu",{"name":39,"role":35,"phone":40,"phoneExt":25,"email":41},"Rebecca Keneally","843-792-0136","keneally@musc.edu",[43,61],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Charleston","South Carolina","29425","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-79.93275,32.77632,{"lat":54,"lon":53},[57,60],{"name":58,"role":35,"phone":59,"phoneExt":25,"email":37},"Xingbao Li, M.D","843 7925729",{"name":58,"role":32,"phone":25,"phoneExt":25,"email":25},{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":62,"geoPoint":64,"contacts":65},{"type":51,"coordinates":63},[53,54],{"lat":54,"lon":53},[66,67],{"name":31,"role":35,"phone":36,"phoneExt":25,"email":37},{"name":39,"role":35,"phone":40,"phoneExt":25,"email":41},{"type":32,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Xingbao L","Associate Professor",[72],{"name":73,"class":74},"National Institute on Drug Abuse (NIDA)","NIH","100431816","rtms-targets-neural-circuits-for-smoking-cessation-100431816",false,"NCT04903028","RTMS Targets Neural Circuits for Smoking Cessation","RTMS Manipulates Imbalanced Drive-reward and Executive Control Circuitry for Smoking Cessation","Inclusion Criteria\n\n* Be between the ages of 22 and 70 years old.\n* Smoke 10 or more cigarettes per day and have a carbon monoxide (CO) level \\> 10 ppm indicative of recent smoking.\n* Have not received substance abuse treatment within the previous 30 days.\n* Meet the criteria for tobacco use disorder as determined by DSM-5.\n* Be in stable mental and physical health.\n* If female, test non-pregnant and use adequate birth control.\n* Show no evidence of focal or diffuse brain lesions on MRI.\n* Be willing to provide informed consent.\n* Be able to comply with protocol requirements and likely to complete all study procedures.\n* Be motivated to quit smoking (based on responses of \"very likely,\" or \"somewhat likely\" in the motivation questionnaire).\n\nExclusion Criteria\n\n* Current moderate to severe substance use of any psychoactive substances other than nicotine or caffeine, as defined by DSM-V criteria.\n* Contraindications to MRI (e.g., presence of metal in the skull, orbital or intracranial cavity, or having claustrophobia).\n* Contraindication to rTMS.\n* History of autoimmune, endocrine, viral, or vascular disorders affecting the brain.\n* History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment.\n* Unstable cardiac disease, uncontrolled hypertension, severe renal or liver insufficiency, or sleep apnea.\n* Lifetime history of major Axis I disorders such as: bipolar affective disorder (BPAD), schizophrenia, post-traumatic stress disorder (PTSD), dementia, suicidal ideation or major depression.\n* Self-report of \\>21 standard alcohol drinks per week in any week in the 30 days prior to screening.\n* Use of other forms of nicotine delivery, such as nicotine patches, electronic cigarettes, gum, nasal spray, inhalers, and nicotine lozenges.\n* Use of other tobacco products, including cigars, cigarillos, chew, snuff, and pouches\u002Fsnus.\n* Previous treatment with TMS.",true,"ALL","22 Years","70 Years",{"count":87,"type":88},64,"ESTIMATED","INTERVENTIONAL",[91],"NA","Cigarette smoking is a significant public health concern. Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that has already displayed remarkable potential for producing novel, non-pharmacological interventions for depression and cigarette smokers. In this study, investigators will use brain MRI to guide TMS therapy for smoking cessation.",[94,95],"Tobacco Use","Cigarette Smoking",[97],"Tobacco use disorder, rTMS, smoking cessation","2026-04-13",{"date":100,"type":101},"2026-04-16","ACTUAL",{"date":103,"type":101},"2021-05-15",{"date":105,"type":88},"2027-04-04",{"name":5,"class":6},2]