[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100483077":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":80,"collaborators":26,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":26,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":26,"enrollmentInfo":91,"targetDuration":26,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"University of Alberta","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Enrolment in rTMS sessions alone","ACTIVE_COMPARATOR","All study participants will be scheduled to receive 30 sessions of rTMS treatment for 6 weeks as pre-established by the Alberta Health Services Strategic Clinical Network for Addiction and Mental Health and Nova Scotia Health.",[13],"Device: Repetitive Transcranial Magnetic Stimulation (rTMS)",{"label":15,"type":16,"description":17,"interventionNames":18},"Enrolment in rTMS sessions plus Text4Support","EXPERIMENTAL","Participants in the rTMS plus Text4Support group of the study would be assisted by a study team member assigned that purpose to register onto the Text4Support program. The process would require all participants to input their phone numbers into the Text4Support platform that will be used to deliver the daily messages. Starting a day after enrollment, participants will receive daily supportive text messages designed by mental health therapists, clinical psychologists, psychiatrists, and mental health service users. These messages are based on cognitive behavior therapy principles crafted to enhance positively the mood of its users with depressive symptoms and other related mental health problems of concern. The messages will be pre-programmed into a software program that will deliver the messages to participants automatically to the participants' mobile phones at 10 AM (Mountain Time) and 12 PM (Atlantic Time), and each participant will receive these messages continuously for 6 weeks.",[19],"Device: Repetitive Transcranial Magnetic Stimulation (rTMS) Plus Text4Support",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Repetitive Transcranial Magnetic Stimulation (rTMS)","rTMS uses powerful (1.0-2.5 Tesla), focused magnetic field pulses to induce electrical currents in neural tissue noninvasively, via an inductor coil placed against the scalp.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Repetitive Transcranial Magnetic Stimulation (rTMS) Plus Text4Support","rTMS uses powerful (1.0-2.5 Tesla), focused magnetic field pulses to induce electrical currents in neural tissue noninvasively, via an inductor coil placed against the scalp.\n\nText4Support:\n\nText4Support is one of the ResilienceNHope suites of supportive text messaging programs delivered by the Global Psychological eHealth Foundation \\[80\\]. The program allows users to receive daily supportive text messages which have been written by a team of cognitive-behavioral therapists and mental health professionals in collaboration with users of mental health services. The aim of this Text4Support depression program is to enhance positively the mood of patients with clinical depression. The program operates through the use of positive reinforcement to correct distorted or negative thought patterns.",[15],[32],{"name":33,"affiliation":34,"role":35},"Vincent Agyapong, MD, Ph.D","Division of Community Psychiatry, University of Alberta","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","780-215-7771","agyapong@ualberta.ca",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Medard K Adu, BEd, MSc","5879376733","medard@ualberta.ca",[46,64],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Edmonton Mental Health Clinic","RECRUITING","Edmonton","Alberta","T6R 3P5","Canada","CA",{"type":55,"coordinates":56},"Point",[57,58],-113.46871,53.55014,{"lat":58,"lon":57},[61],{"name":62,"role":38,"phone":63,"phoneExt":26,"email":40},"Vincent Israel O Agyapong, PhD","17807144315",{"facility":65,"status":48,"city":66,"state":67,"zip":68,"country":52,"countryCode":53,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Nova Scotia Health - Abbie J. Lane Memorial Building QEII Health Sciences Centre","Halifax","Nova Scotia","B3H 2E2",{"type":55,"coordinates":70},[71,72],-63.57688,44.64269,{"lat":72,"lon":71},[75,78],{"name":76,"role":38,"phone":26,"phoneExt":26,"email":77},"Vincent Agyapong","vincent.agyapong@nshealth.ca",{"name":79,"role":35,"phone":26,"phoneExt":26,"email":26},"Vincente Agyapong",{"type":81,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100483077","rtms-with-and-without-text4support-for-the-treatment-of-resistant-depression-100483077",false,"NCT05570344","rTMS With and Without Text4Support for the Treatment of Resistant Depression.","Repetitive Transcranial Magnetic Stimulation With and Without Text4Support for the Treatment of Resistant Depression: Patient-centered Multicentral Randomized Controlled Pilot Trial. Protocol.","Inclusion Criteria:\n\n* aged 18 and above and diagnosed with MDD based upon the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and who have at least failed two or more standard antidepressant treatments during the current episode. Participants may be on psychotropic medications including antidepressants, antipsychotics, benzodiazepines, and anticonvulsants. They must have a good understanding of the English language. Must have access to a smartphone and be able to receive and read text messages. Must be willing to provide written informed consent upon acceptance into the study.\n\nExclusion Criteria:\n\n* Patients below the age of 18.\n* Having diagnosis such as the following conditions (current unless otherwise stated): A neurological disorder, including a history of seizures, having primary or secondary tumors in the central nervous system, cerebrovascular disease, stroke, cerebral aneurysm, movement disorder,\n* Having a current psychotic disorder such as substance-induced psychosis, psychotic disorder due to a medical condition, or MDD with psychotic features at the time of screening\n* Having a current personality disorder that may hinder the patient's participation in this research or may have the potential of affecting cognition and ability to fully participate in the study.\n* Having a learning disability as per identified through medical history or by the investigator during the assessment process.\n* Participants involved in any drug or device clinical trial within the last six weeks before the screening visit and\u002For involvement in another clinical trial for the duration of this study.\n* Pregnant and breastfeeding women.\n* Identification and\u002For the sudden appearance of any condition or instance from the mentioned above and based on the expertise of the investigators that have the potential to hinder the progress and completion and\u002For become a confounding factor on the outcome assessments.","ALL","18 Years",{"count":92,"type":93},200,"ESTIMATED","INTERVENTIONAL",[96],"NA","This study is a multicenter prospective, parallel design, two-arm, rater-blinded randomized controlled pilot trial. Participants will be randomly assigned to one of two treatment conditions. In the first condition, treatment consists of rTMS sessions combined with Text4Support. The second condition is made up of the treatment as usual (rTMS sessions alone). The recruitment process is scheduled to last 12 months. It will involve active treatment for six weeks and follow-up period observation periods of 1,3, and 6 months for participants in both arms of the study. Participants will be recruited from four different centers for this project. Two centers (the Addiction and Mental Health clinic and the Alberta day hospital) will be from the large, sociodemographic diverse city of Edmonton in Alberta Western Canada. The remaining two centers will be in Halifax and Annapolis Valley in Nova Scotia, Canada.",[99],"Depressive Disorder, Treatment-Resistant",[101,102,103,104],"Repetitive Transcranial Magnetic Stimulation","Treatment of Resistant Depression","Patient - Centered Randomized Controlled Pilot Trial","Supportive Text messages (Text4Support)","2026-04-07",{"date":107,"type":108},"2026-04-13","ACTUAL",{"date":110,"type":108},"2023-02-01",{"date":112,"type":93},"2026-12-31",{"name":5,"class":6},2]