[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598303":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":503,"collaborators":26,"id":505,"slug":506,"hasResults":507,"nctId":508,"briefTitle":509,"officialTitle":509,"acronym":510,"eligibilityCriteria":511,"healthyVolunteers":507,"sex":512,"minAge":513,"maxAge":26,"enrollmentInfo":514,"targetDuration":26,"studyType":517,"phases":518,"briefSummary":520,"conditions":521,"keywords":523,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":529,"lastUpdatePostDateStruct":530,"startDateStruct":533,"completionDateStruct":535,"leadSponsor":537,"locationsCount":538},{"fullName":5,"class":6},"Boston Scientific Corporation","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CRT Cohort","ACTIVE_COMPARATOR","Participants will be randomized, implanted with a BSC CRT-D device using a Quadripolar lead, and device programmed to the respective cohort.",[13],"Device: CRT-D with a Quadripolar LV lead",{"label":15,"type":16,"description":17,"interventionNames":18},"LBBA Cohort","EXPERIMENTAL","Participants will be randomized, implanted with a BSC CRT-D using the INGEVITY+ pace\u002Fsense lead implanted in the LBBA, and device programmed to the respective cohort.",[19],"Device: CRT-D with INGEVITY+ pace\u002Fsense lead",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","CRT-D with a Quadripolar LV lead","Participants randomized to this cohort will receive a BSC system: CRT-D, Right Atrial Lead (RA), Defibrillation Lead (RV), Quadripolar LV Lead.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"CRT-D with INGEVITY+ pace\u002Fsense lead","Participants randomized to this cohort will receive a BSC system: CRT-D, Right Atrial Lead (RA), Defibrillation Lead (RV), INGEVITY+ pace\u002Fsense Lead (implanted in the LBBA)",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Jacqueline Beaulieu","CONTACT","1-800-227-3422","jacqueline.beaulieu@bsci.com",[38,57,70,84,98,106,119,133,146,159,173,187,200,209,223,236,250,264,278,292,306,320,333,347,361,373,383,396,410,424,434,448,462,476,490],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Heart Center Research, LLC","RECRUITING","Huntsville","Alabama","35801","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-86.58594,34.7304,{"lat":50,"lon":49},[53,55],{"name":54,"role":34,"phone":26,"phoneExt":26,"email":26},"John Jennings, Dr.",{"name":54,"role":56,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"facility":58,"status":40,"city":59,"state":42,"zip":60,"country":44,"countryCode":45,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Mobile Infirmary Medical Center","Mobile","36608",{"type":47,"coordinates":62},[63,64],-88.04305,30.69436,{"lat":64,"lon":63},[67,69],{"name":68,"role":34,"phone":26,"phoneExt":26,"email":26},"Ernest Matthew Quin, Dr.",{"name":68,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":71,"status":40,"city":72,"state":73,"zip":74,"country":44,"countryCode":45,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Arrhythmia Research Group","Jonesboro","Arkansas","72401",{"type":47,"coordinates":76},[77,78],-90.70428,35.8423,{"lat":78,"lon":77},[81,83],{"name":82,"role":34,"phone":26,"phoneExt":26,"email":26},"Devi Nair, Dr.",{"name":82,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":85,"status":40,"city":86,"state":87,"zip":88,"country":44,"countryCode":45,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"Scripps Memorial Hospital","La Jolla","California","92037",{"type":47,"coordinates":90},[91,92],-117.2742,32.84727,{"lat":92,"lon":91},[95,97],{"name":96,"role":34,"phone":26,"phoneExt":26,"email":26},"Nicolas Olson, MD",{"name":96,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":99,"status":40,"city":100,"state":87,"zip":101,"country":44,"countryCode":45,"cosmosGeoPoint":26,"geoPoint":26,"contacts":102},"Cedars Sinai Medical Center","Las Angeles","90048",[103,105],{"name":104,"role":34,"phone":26,"phoneExt":26,"email":26},"Ashkan Ehdaie, MD",{"name":104,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":107,"status":40,"city":108,"state":87,"zip":109,"country":44,"countryCode":45,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"Alta Bates Summit Medical Center","Oakland","94609",{"type":47,"coordinates":111},[112,113],-122.2708,37.80437,{"lat":113,"lon":112},[116,118],{"name":117,"role":34,"phone":26,"phoneExt":26,"email":26},"Rajan Shah, Dr.",{"name":117,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":120,"status":40,"city":121,"state":87,"zip":122,"country":44,"countryCode":45,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"Pacific Heart Institute","Santa Monica","90404",{"type":47,"coordinates":124},[125,126],-118.49138,34.01949,{"lat":126,"lon":125},[129,131],{"name":130,"role":34,"phone":26,"phoneExt":26,"email":26},"Stephen Tang, MD",{"name":132,"role":56,"phone":26,"phoneExt":26,"email":26},"Stephan Tang, MD",{"facility":134,"status":40,"city":135,"state":87,"zip":136,"country":44,"countryCode":45,"cosmosGeoPoint":137,"geoPoint":141,"contacts":142},"Torrance Medical Center","Torrance","90505",{"type":47,"coordinates":138},[139,140],-118.34063,33.83585,{"lat":140,"lon":139},[143,145],{"name":144,"role":34,"phone":26,"phoneExt":26,"email":26},"Gene Kim, MD",{"name":144,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":147,"status":40,"city":148,"state":87,"zip":149,"country":44,"countryCode":45,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"Cardiology Associates Medical Group, Inc.","Ventura","93003",{"type":47,"coordinates":151},[152,153],-119.29317,34.27834,{"lat":153,"lon":152},[156,158],{"name":157,"role":34,"phone":26,"phoneExt":26,"email":26},"Jonathan Dukes, Dr.",{"name":157,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":160,"status":40,"city":161,"state":162,"zip":163,"country":44,"countryCode":45,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"Washington Hospital Center","Washington D.C.","District of Columbia","20010",{"type":47,"coordinates":165},[166,167],-77.03637,38.89511,{"lat":167,"lon":166},[170,172],{"name":171,"role":34,"phone":26,"phoneExt":26,"email":26},"Cyrus Hadadi, MD",{"name":171,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":174,"status":40,"city":175,"state":176,"zip":177,"country":44,"countryCode":45,"cosmosGeoPoint":178,"geoPoint":182,"contacts":183},"Sarasota Memorial Hospital","Sarasota","Florida","34239",{"type":47,"coordinates":179},[180,181],-82.53065,27.33643,{"lat":181,"lon":180},[184,186],{"name":185,"role":34,"phone":26,"phoneExt":26,"email":26},"Antonio Moretta, Dr.",{"name":185,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":188,"status":40,"city":189,"state":176,"zip":190,"country":44,"countryCode":45,"cosmosGeoPoint":191,"geoPoint":195,"contacts":196},"AdventHealth Tampa","Tampa","33613",{"type":47,"coordinates":192},[193,194],-82.45843,27.94752,{"lat":194,"lon":193},[197,199],{"name":198,"role":34,"phone":26,"phoneExt":26,"email":26},"Kenneth Yamamura, MD",{"name":198,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":201,"status":40,"city":202,"state":203,"zip":204,"country":44,"countryCode":45,"cosmosGeoPoint":26,"geoPoint":26,"contacts":205},"Emory University Hospital","Altanta","Georgia","30322",[206,208],{"name":207,"role":34,"phone":26,"phoneExt":26,"email":26},"Anand Shah, MD",{"name":207,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":210,"status":40,"city":211,"state":212,"zip":213,"country":44,"countryCode":45,"cosmosGeoPoint":214,"geoPoint":218,"contacts":219},"University of Chicago","Hinsdale","Illinois","60521",{"type":47,"coordinates":215},[216,217],-87.93701,41.80086,{"lat":217,"lon":216},[220,222],{"name":221,"role":34,"phone":26,"phoneExt":26,"email":26},"Shrinath Yeshwant, MD",{"name":221,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":224,"status":40,"city":225,"state":212,"zip":226,"country":44,"countryCode":45,"cosmosGeoPoint":227,"geoPoint":231,"contacts":232},"Midwest Cardiovascular Institute","Naperville","60540",{"type":47,"coordinates":228},[229,230],-88.14729,41.78586,{"lat":230,"lon":229},[233,235],{"name":234,"role":34,"phone":26,"phoneExt":26,"email":26},"Moeen Saleem, Dr.",{"name":234,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":237,"status":40,"city":238,"state":239,"zip":240,"country":44,"countryCode":45,"cosmosGeoPoint":241,"geoPoint":245,"contacts":246},"Community Heart and Vascular Hospital","Indianapolis","Indiana","46250",{"type":47,"coordinates":242},[243,244],-86.15804,39.76838,{"lat":244,"lon":243},[247,249],{"name":248,"role":34,"phone":26,"phoneExt":26,"email":26},"Krishna Malineni, MD",{"name":248,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":251,"status":40,"city":252,"state":253,"zip":254,"country":44,"countryCode":45,"cosmosGeoPoint":255,"geoPoint":259,"contacts":260},"University of Iowa Hospitals and Clinics","Iowa City","Iowa","52242",{"type":47,"coordinates":256},[257,258],-91.53017,41.66113,{"lat":258,"lon":257},[261,263],{"name":262,"role":34,"phone":26,"phoneExt":26,"email":26},"Paari Dominic, MD",{"name":262,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":265,"status":40,"city":266,"state":267,"zip":268,"country":44,"countryCode":45,"cosmosGeoPoint":269,"geoPoint":273,"contacts":274},"Baptist Hospital East Louisville","Louisville","Kentucky","40207",{"type":47,"coordinates":270},[271,272],-85.75941,38.25424,{"lat":272,"lon":271},[275,277],{"name":276,"role":34,"phone":26,"phoneExt":26,"email":26},"Kevin Parrott, MD",{"name":276,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":279,"status":40,"city":280,"state":281,"zip":282,"country":44,"countryCode":45,"cosmosGeoPoint":283,"geoPoint":287,"contacts":288},"Southcoast Physicians Group","Fall River","Massachusetts","02720",{"type":47,"coordinates":284},[285,286],-71.15505,41.70149,{"lat":286,"lon":285},[289,291],{"name":290,"role":34,"phone":26,"phoneExt":26,"email":26},"Arnoldas Giedrimas, MD",{"name":290,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":293,"status":40,"city":294,"state":295,"zip":296,"country":44,"countryCode":45,"cosmosGeoPoint":297,"geoPoint":301,"contacts":302},"Corewell Health","Grand Rapids","Michigan","49525",{"type":47,"coordinates":298},[299,300],-85.66809,42.96336,{"lat":300,"lon":299},[303,305],{"name":304,"role":34,"phone":26,"phoneExt":26,"email":26},"Jawad Wassim, MD",{"name":304,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":307,"status":40,"city":308,"state":309,"zip":310,"country":44,"countryCode":45,"cosmosGeoPoint":311,"geoPoint":315,"contacts":316},"St. Mary's Duluth Clinic Regional Heart Center","Duluth","Minnesota","55805",{"type":47,"coordinates":312},[313,314],-92.10658,46.78327,{"lat":314,"lon":313},[317,319],{"name":318,"role":34,"phone":26,"phoneExt":26,"email":26},"Christopher Latanich, MD",{"name":318,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":321,"status":40,"city":322,"state":309,"zip":323,"country":44,"countryCode":45,"cosmosGeoPoint":324,"geoPoint":328,"contacts":329},"Centracare Heart and Vascular Center","Saint Cloud","56303",{"type":47,"coordinates":325},[326,327],-94.16249,45.5608,{"lat":327,"lon":326},[330,332],{"name":331,"role":34,"phone":26,"phoneExt":26,"email":26},"Hardik Doshi, Dr.",{"name":331,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":334,"status":40,"city":335,"state":336,"zip":337,"country":44,"countryCode":45,"cosmosGeoPoint":338,"geoPoint":342,"contacts":343},"Morristown Medical Center","Morristown","New Jersey","07932",{"type":47,"coordinates":339},[340,341],-74.48154,40.79677,{"lat":341,"lon":340},[344,346],{"name":345,"role":34,"phone":26,"phoneExt":26,"email":26},"Michael Katz, MD",{"name":345,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":348,"status":40,"city":349,"state":350,"zip":351,"country":44,"countryCode":45,"cosmosGeoPoint":352,"geoPoint":356,"contacts":357},"New York Hospital Queens","Flushing","New York","11355",{"type":47,"coordinates":353},[354,355],-73.81736,40.76538,{"lat":355,"lon":354},[358,360],{"name":359,"role":34,"phone":26,"phoneExt":26,"email":26},"Seth Goldbarg, Dr.",{"name":359,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":362,"status":40,"city":350,"state":350,"zip":363,"country":44,"countryCode":45,"cosmosGeoPoint":364,"geoPoint":368,"contacts":369},"Weill Cornell Medical University","10021",{"type":47,"coordinates":365},[366,367],-74.00597,40.71427,{"lat":367,"lon":366},[370,372],{"name":371,"role":34,"phone":26,"phoneExt":26,"email":26},"Jim Cheung, Dr.",{"name":371,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":374,"status":40,"city":350,"state":350,"zip":375,"country":44,"countryCode":45,"cosmosGeoPoint":376,"geoPoint":378,"contacts":379},"Rochester General Hospital","14621",{"type":47,"coordinates":377},[366,367],{"lat":367,"lon":366},[380,382],{"name":381,"role":34,"phone":26,"phoneExt":26,"email":26},"Dmitry Chuprun, MD",{"name":381,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":384,"status":40,"city":385,"state":350,"zip":386,"country":44,"countryCode":45,"cosmosGeoPoint":387,"geoPoint":391,"contacts":392},"SUNY-Upstate Medical University","Syracuse","13057",{"type":47,"coordinates":388},[389,390],-76.14742,43.04812,{"lat":390,"lon":389},[393,395],{"name":394,"role":34,"phone":26,"phoneExt":26,"email":26},"Jorge Romero, MD",{"name":394,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":397,"status":40,"city":398,"state":399,"zip":400,"country":44,"countryCode":45,"cosmosGeoPoint":401,"geoPoint":405,"contacts":406},"Duke University Medical Center","Durham","North Carolina","27710",{"type":47,"coordinates":402},[403,404],-78.89862,35.99403,{"lat":404,"lon":403},[407,409],{"name":408,"role":34,"phone":26,"phoneExt":26,"email":26},"Daniel Friedman, MD",{"name":408,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":411,"status":40,"city":412,"state":413,"zip":414,"country":44,"countryCode":45,"cosmosGeoPoint":415,"geoPoint":419,"contacts":420},"OhioHealth Research and Innovation Institute-Riverside Methodist Hospital","Columbus","Ohio","43214",{"type":47,"coordinates":416},[417,418],-82.99879,39.96118,{"lat":418,"lon":417},[421,423],{"name":422,"role":34,"phone":26,"phoneExt":26,"email":26},"Anish Amin, MD",{"name":422,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":425,"status":40,"city":412,"state":413,"zip":426,"country":44,"countryCode":45,"cosmosGeoPoint":427,"geoPoint":429,"contacts":430},"Mount Carmel Health System","43219",{"type":47,"coordinates":428},[417,418],{"lat":418,"lon":417},[431,433],{"name":432,"role":34,"phone":26,"phoneExt":26,"email":26},"Kamel Addo, MD",{"name":432,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":435,"status":40,"city":436,"state":437,"zip":438,"country":44,"countryCode":45,"cosmosGeoPoint":439,"geoPoint":443,"contacts":444},"Penn Presbyterian Medical Center","Philadelphia","Pennsylvania","19104",{"type":47,"coordinates":440},[441,442],-75.16362,39.95238,{"lat":442,"lon":441},[445,447],{"name":446,"role":34,"phone":26,"phoneExt":26,"email":26},"John Bullinga, MD",{"name":446,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":449,"status":40,"city":450,"state":451,"zip":452,"country":44,"countryCode":45,"cosmosGeoPoint":453,"geoPoint":457,"contacts":458},"Avera Heart Hospital of South Dakota","Sioux Falls","South Dakota","57108",{"type":47,"coordinates":454},[455,456],-96.72796,43.54369,{"lat":456,"lon":455},[459,461],{"name":460,"role":34,"phone":26,"phoneExt":26,"email":26},"Christopher Stanton, Dr.",{"name":460,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":463,"status":40,"city":464,"state":465,"zip":466,"country":44,"countryCode":45,"cosmosGeoPoint":467,"geoPoint":471,"contacts":472},"St.Thomas Health","Nashville","Tennessee","37205",{"type":47,"coordinates":468},[469,470],-86.78444,36.16589,{"lat":470,"lon":469},[473,475],{"name":474,"role":34,"phone":26,"phoneExt":26,"email":26},"Ricardo Lugo, MD",{"name":474,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":477,"status":40,"city":478,"state":479,"zip":480,"country":44,"countryCode":45,"cosmosGeoPoint":481,"geoPoint":485,"contacts":486},"Heart Hospital Baylor Plano","Plano","Texas","75093",{"type":47,"coordinates":482},[483,484],-96.69889,33.01984,{"lat":484,"lon":483},[487,489],{"name":488,"role":34,"phone":26,"phoneExt":26,"email":26},"Mustafa Dohadwala, MD",{"name":488,"role":56,"phone":26,"phoneExt":26,"email":26},{"facility":491,"status":40,"city":492,"state":479,"zip":493,"country":44,"countryCode":45,"cosmosGeoPoint":494,"geoPoint":498,"contacts":499},"Christus Trinity Mother Frances Health System","Tyler","75701",{"type":47,"coordinates":495},[496,497],-95.30106,32.35126,{"lat":497,"lon":496},[500,502],{"name":501,"role":34,"phone":26,"phoneExt":26,"email":26},"Stanislov Weiner, Dr.",{"name":501,"role":56,"phone":26,"phoneExt":26,"email":26},{"type":504,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100598303","safety-and-effectiveness-of-left-bundle-branch-area-pacing-versus-conventional-cardiac-resynchronization-therapy-in-heart-failure-100598303",false,"NCT07069738","Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure","SYNCHRONICITY","Inclusion Criteria:\n\n1. Patient is age 18 years or above, or of legal age to give informed consent specific to state and national law\n2. Patient meets a guideline-based indication for a de novo CRT-D device\n3. Primary prevention indication for ICD therapy\n4. Ischemic or nonischemic cardiomyopathy with LVEF ≤ 35% within 6 months of enrollment (LVEF must be assessed after the subject has been on GDMT for a minimum of 3 months) using an appropriate method of assessment (i.e. Echo, MRI, etc)\n5. NYHA class II-IV despite maximally tolerated guideline directed medical therapy (GDMT)\\* for at least 3 months\n\n   \\*GDMT is defined as all four drug classes listed below for at least 3 months prior to enrollment unless the investigator provides justification (e.g., contraindicated, not tolerated or cost): Renin Angiotensin System Inhibitors (ACE, ARB, or ARNI) Evidence based betablockers (metoprolol succinate, carvedilol, bisoprolol) Mineralocorticoid antagonists SGLT2 Inhibitor medications\n6. Sinus rhythm with left bundle branch block (LBBB) defined as a QRS ≥ 140 ms in men and ≥ 130 ms in women with a predominantly negative deflection (QS or rS in lead V1 and mid QRS notching or slurring in at least two of the following leads: 1, aVL, V1, V2, V5, V6) within 3 months of enrollment\n7. Patient is willing to participate in LATITUDE™ NXT remote patient monitoring\n8. Patient is willing and capable of providing informed consent and participating in all testing associated with this investigation at an approved study site and at the protocol defined intervals (Note: Use of a legally authorized representative (LAR) is not allowed)\n9. Patient plans to remain geographically stable (not permanently moving to another location) and can commit to all study participation requirements (procedure, follow-up visits and testing requirements)\n\nExclusion Criteria:\n\n1. Persistent or permanent atrial fibrillation (AF) within 3 months prior to enrollment and documented in the medical record\n2. Frequent premature ventricular contractions (PVCs), atrial arrhythmias, and\u002For other causes of expected percentage of cardiac physiologic pacing (CPP) delivery below 95% at the time of enrollment\n3. Non-LBBB conduction abnormalities (including right bundle branch block (RBB) or intraventricular conduction delay (IVCD)) within 3 months prior to enrollment\n4. Complete, second degree or high degree atrioventricular (AV) block, that requires pacing at the time of enrollment\n5. Current or prior pacemaker, ICD or CRT implant (Also includes non-transvenous ICD technology and leadless pacemakers)\n6. Prior or planned mechanical or bioprosthetic tricuspid valve replacement\n7. Currently receiving or previously received positive inotrope therapy within 3 months prior to enrollment\n8. Unstable angina, acute myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention within 3 months prior to enrollment\n9. History of heart transplantation or left ventricular assist device (LVAD) implantation\n10. Less than 1 year of life expectancy at the time of enrollment\n11. Anticipated heart transplantation or LVAD implantation within 1 year of enrollment\n12. History of ventricular septal defect (VSD)\n13. Complex congenital heart disease\n14. Documented diagnosis of cardiac amyloidosis\n15. Known occlusion or other reason limiting central venous access for transvenous leads\n16. Women of childbearing potential who are, or plan to become, pregnant during the course of the study (assessment per investigator's discretion)\n17. Patient currently requiring dialysis\n18. Patient with known or suspected sensitivity to Dexamethasone Acetate (DXA)\n19. Patient with contrast dye allergy or unwilling\u002Fable to undergo pre-treatment with steroids and\u002For diphenhydramine\n20. Inability or refusal to comply with the follow-up schedule including subject living at such a distance from the investigational site that attending follow-up visits would be unusually difficult or burdensome\n21. Patient is enrolled in any other concurrent study. Co-enrollment into other studies such as observational studies\u002Fregistries needs prior written approval by BSC. Local mandatory governmental registries are accepted for co-enrollment without approval by BSC.","ALL","18 Years",{"count":515,"type":516},850,"ESTIMATED","INTERVENTIONAL",[519],"NA","This study will compare two different methods to pace the heart to treat heart failure including:\n\n1. The current standard method of implanting a pacing lead in a vein on the surface of the left lower chamber of the heart (left ventricle) to deliver heart failure therapy. This method is called Cardiac Resynchronization Therapy (CRT).\n2. The other method is using a lead implanted in the Left Bundle Branch Area (LBBA) of your heart. This method is called Left Bundle Branch Area Pacing or LBBAP. This lead is approved by the Food and Drug Administration (FDA) to be implanted in this area of the heart, but not to provide heart failure treatment.",[522],"Heart Failure - NYHA II - IV",[524,525,526,527,528],"Heart Failure","Conduction System Pacing","Primary Prevention","Cardiac Resynchronization Therapy","Left Bundle Branch Area Pacing","2026-07-01",{"date":531,"type":532},"2026-07-02","ACTUAL",{"date":534,"type":532},"2025-10-22",{"date":536,"type":516},"2029-11",{"name":5,"class":6},35]