[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619699":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":55,"collaborators":26,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":26,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Second Affiliated Hospital of Nanchang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Combination Therapy Group","EXPERIMENTAL","Participants will receive arthroscopic rotator cuff repair and adhesion release, followed by an intra-articular injection of Liposomal Bupivacaine combined with Compound Betamethasone.",[13],"Drug: Liposomal Bupivacaine + Compound Betamethasone Injection",{"label":15,"type":16,"description":17,"interventionNames":18},"Monotherapy (Control) Group","ACTIVE_COMPARATOR","Participants will receive arthroscopic rotator cuff repair and adhesion release, followed by an intra-articular injection of Compound Betamethasone alone.",[19],"Drug: Compound Betamethasone Injection",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Liposomal Bupivacaine + Compound Betamethasone Injection","Intra-articular injection of a mixture containing Liposomal Bupivacaine and Compound Betamethasone under arthroscopic guidance after standard surgical procedures.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Compound Betamethasone Injection","Intra-articular injection of Compound Betamethasone alone under arthroscopic guidance after standard surgical procedures.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Hao Liang, MD","CONTACT","+86-13607008562","haoliang201@163.com",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"The Second Affiliated Hospital of Nanchang University","RECRUITING","Nanchang","Jiangxi","330006","China","CN",{"type":47,"coordinates":48},"Point",[49,50],115.85306,28.68396,{"lat":50,"lon":49},[53],{"name":33,"role":34,"phone":54,"phoneExt":26,"email":36},"13607008562",{"type":56,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100619699","safety-and-efficacy-of-platelet-rich-plasma-combined-with-compound-betamethasone-in-arthroscopic-surgery-for-rotator-cuff-injury-with-shoulder-adhesion-a-prospective-multicenter-randomized-controlled-trial-100619699",false,"NCT07348016","Safety and Efficacy of Platelet-Rich Plasma Combined With Compound Betamethasone in Arthroscopic Surgery for Rotator Cuff Injury With Shoulder Adhesion: A Prospective, Multicenter, Randomized Controlled Trial","PRP+CB for RC","Inclusion Criteria:\n\nAge between 18 and 70 years.\n\nClinical and MRI diagnosis of full-thickness rotator cuff tear.\n\nPresence of shoulder stiffness\u002Fadhesion defined as passive range of motion less than 100° in forward flexion and\u002For less than 10° in external rotation (or according to your specific definition).\n\nScheduled for arthroscopic rotator cuff repair and capsular release.\n\nWilling and able to provide written informed consent.\n\nWilling to comply with all study procedures and follow-up visits.\n\nExclusion Criteria :\n\nMassive, irreparable rotator cuff tear.\n\nSevere glenohumeral osteoarthritis (Grade III or IV according to Samilson-Prieto classification).\n\nHistory of shoulder infection, fracture, or previous surgery on the affected shoulder.\n\nKnown allergy or contraindication to betamethasone, local anesthetics, or components of PRP preparation.\n\nSystemic inflammatory arthritis (e.g., rheumatoid arthritis).\n\nCoagulation disorders or use of anticoagulants that cannot be safely suspended perioperatively.\n\nPregnancy or lactation.\n\nParticipation in another clinical trial within the past 3 months.\n\nAny medical or psychiatric condition that, in the investigator's opinion, would compromise patient safety or compliance with the study protocol.","ALL","18 Years","70 Years",{"count":68,"type":69},70,"ESTIMATED","INTERVENTIONAL",[72],"NA","Background: Patients undergoing arthroscopic surgery for rotator cuff tears with shoulder adhesion often experience significant postoperative pain and stiffness. This study investigates whether adding a long-acting local anesthetic (Liposomal Bupivacaine) to a standard anti-inflammatory steroid injection (Compound Betamethasone) during surgery can improve outcomes.\n\nMethods: This is a prospective, randomized, double-blind, controlled trial. Approximately 70 eligible adult patients will be randomly assigned to one of two groups: (1) the Combination Group, receiving an intra-articular injection of Liposomal Bupivacaine plus Compound Betamethasone after surgery, or (2) the Control Group, receiving Compound Betamethasone alone. Patients and outcome assessors will not know the group assignment.\n\nWhat participants will do: All participants will receive standard arthroscopic rotator cuff repair and adhesion release. They will be followed for 12 months after surgery, with assessments at multiple time points (from hours to months post-op) to measure pain levels, shoulder function, range of motion, and tendon healing via MRI.\n\nMain Goals: The primary goal is to compare the improvement in UCLA shoulder scores between the two groups at 12 months. Secondary goals include comparing pain scores, other functional scores (Constant-Murley), joint mobility, MRI findings, and safety (complication rates).",[75,76],"Rotator Cuff Injuries","Adhesions",[78,79,80,81,82,83],"Platelet-Rich Plasma","Compound Betamethasone","Arthroscopy","Randomized Controlled Trial","Shoulder","Stiffness","2026-01-08",{"date":86,"type":87},"2026-01-16","ACTUAL",{"date":89,"type":87},"2025-08-01",{"date":91,"type":69},"2028-12-01",{"name":5,"class":6},1]