[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100526959":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":37,"responsibleParty":57,"collaborators":59,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":18,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":18,"overallStatus":40,"whyStopped":18,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"First Affiliated Hospital Xi'an Jiaotong University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"RIC group","EXPERIMENTAL","In the RIC group, patients will undergo RIC training in the 3 days before and 7 days after the CABG surgery.",[13],"Device: Remote ischemic conditioning",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","In the control group, a blood pressure cuff, same as the cuff in the RIC group, will be placed on both upper arms of the patients but only pressurized to 60 mmHg. The rest of the procedures will be the same.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DEVICE","Remote ischemic conditioning","An automatic programmed blood pressure cuffs will be placed on two upper limbs of the patient and pressurized to 200 mmHg (or at least 20 mmHg higher than the systolic blood pressure if the systolic blood pressure of the patient is above 180 mmHg) with 5 minutes of pressurization and 5 minutes of rest. One pressurization with rest is deemed as one cycle (10 minutes), and 4 cycles will be performed each time (for a total of 40 minutes).",[9],[26],{"name":27,"affiliation":5,"role":28},"Yang Yan","PRINCIPAL_INVESTIGATOR",[30,34],{"name":27,"role":31,"phone":32,"phoneExt":18,"email":33},"CONTACT","+86.29.85323869","yangyan3@xjtu.edu.cn",{"name":35,"role":31,"phone":32,"phoneExt":18,"email":36},"Li Guoliang","liguoliang_med@163.com",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"First Affiliated Hospital of Xi'an Jiantong University","RECRUITING","Xi'an","Shaanxi","710061","China","CN",{"type":47,"coordinates":48},"Point",[49,50],108.92861,34.25833,{"lat":50,"lon":49},[53,56],{"name":54,"role":31,"phone":55,"phoneExt":18,"email":36},"Guoliang Li","+862985323865",{"name":27,"role":31,"phone":55,"phoneExt":18,"email":33},{"type":58,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[60,62,65,67],{"name":61,"class":6},"Beijing Anzhen Hospital",{"name":63,"class":64},"People's Hospital of Qinghai Province","UNKNOWN",{"name":66,"class":64},"The Second Hospital of Yulin City",{"name":68,"class":6},"Baoji Central Hospital","100526959","safety-and-efficacy-of-remote-ischemic-conditioning-for-patients-taking-off-pump-coronary-artery-bypass-grafting-100526959",false,"NCT06141525","Safety and Efficacy of Remote Ischemic Conditioning for Patients Taking Off-pump Coronary Artery Bypass Grafting","Safety and Efficacy of Remote Ischemic Conditioning for Patients Taking Off-pump Coronary Artery Bypass Grafting (IMPROVE): A National, Multi-center, Randomized, Controlled, Open-label, Blinded-endpoint Trial","IMPROVE","Inclusion Criteria:\n\n* Diagnosed with coronary artery disease and require off-pump CABG surgery.\n* Between 18 and 75 years old;\n* Normal left ventricular systolic function (ejection fraction \\>40%) and left ventricular end-diastolic internal diameter (\\\u003C60 mm) in the cardiac ultrasound tests;\n* No or mild heart valve and great vessel abnormalities which do not require surgical intervention;\n* Participants or their authorized relatives agree to participate in the clinical trial and sign the informed consent.\n\nExclusion Criteria:\n\n* Severe tissue injuries.\n* Myalgia, fractures and other peripheral vascular lesions.\n* Bypass graft being the radial artery.\n* Stenosis or severe malformations of the subclavian, jugular and femoral arteries and veins.\n* Previous vagus nerve trunk dissection or vagus nerve block surgery.\n* Other surgical operations at the same time.\n* Patients with pre-existing severe cardiac insufficiency, acute coronary syndromes, malignant hypertension and cardiogenic shock.\n* Severe coagulation abnormality or severe anemia.\n* Severe mental disorder.\n* Malignant tumors.\n* Pregnant or lactating.\n* Increased risk of treatment for patients, according to investigators.\n* Refuse to sign the informed consent form.","ALL","18 Years","70 Years",{"count":81,"type":82},648,"ESTIMATED","INTERVENTIONAL",[85],"NA","Remote ischemic conditioning (RIC) is the process of repeated ischemia and reperfusion in the peripheral vessels, which is proved in reducing IRI in vital organs. This IMPROVE trial plans to enroll 648 patients who are diagnosed with coronary artery disease and are going to take off-pump CABG in five centers in China, to access whether RIC can and improve short-term prognosis.",[88,89,90],"Coronary Artery Bypass Grafting","Remote Ischemic Conditioning","Ischemia-Reperfusion Injury","2024-07-10",{"date":93,"type":94},"2024-07-12","ACTUAL",{"date":96,"type":94},"2023-11-22",{"date":98,"type":82},"2029-03-31",{"name":5,"class":6},1]