[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100337146":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":56,"collaborators":26,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":26,"overallStatus":79,"whyStopped":26,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"The First Hospital of Jilin University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"RIC+Standard medical treatment","ACTIVE_COMPARATOR","Remote ischemic conditioning (RIC) is induced by 4 cycles of 5 min of healthy upper limb ischemia followed by 5 min reperfusion. Limb ischemia was induced by inflations of a blood pressure cuff to 200 mm Hg. RIC will be conducted twice daily for 7 days. Additionally,the patients will be treated with standard medical treatment according to Guidelines for diagnosis and treatment of acute ischemic stroke in China 2014",[13],"Procedure: Remote ischemic conditioning",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham RIC+Standard medical treatment","PLACEBO_COMPARATOR","Remote ischemic conditioning (RIC) is induced by 4 cycles of 5 min of healthy upper limb ischemia followed by 5 min reperfusion. Limb ischemia was induced by inflations of a blood pressure cuff to 60 mm Hg. RIC will be conducted twice daily for 7 days. Additionally,the patients will be treated with standard medical treatment according to Guidelines for diagnosis and treatment of acute ischemic stroke in China 2014",[19],"Procedure: Sham remote ischemic conditioning",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Remote ischemic conditioning","Remote ischemic conditioning (RIC) is induced by 4 cycles of 5 min of healthy upper limb ischemia followed by 5 min reperfusion. Limb ischemia was induced by inflations of a blood pressure cuff to 200 mm Hg. RIC will be conducted twice daily for 7 days.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham remote ischemic conditioning","Remote ischemic conditioning (RIC) is induced by 4 cycles of 5 min of healthy upper limb ischemia followed by 5 min reperfusion. Limb ischemia was induced by inflations of a blood pressure cuff to 60 mm Hg. RIC will be conducted twice daily for 7 days.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Yi Yang, MD, PhD","CONTACT","0086-13756661217","doctor_yangyi@163.com",{"name":38,"role":34,"phone":26,"phoneExt":26,"email":39},"Zhen-Ni Guo, MD","zhen1ni2@163.com",[41],{"facility":42,"status":26,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"First Hospital of Jilin University","Changchun","Jilin","130000","China","CN",{"type":49,"coordinates":50},"Point",[51,52],125.32278,43.88,{"lat":52,"lon":51},[55],{"name":33,"role":34,"phone":26,"phoneExt":26,"email":36},{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Yi Yang","Clinical Trial and Research Center for Stroke","100337146","safety-and-efficacy-of-remote-ischemic-conditioning-in-patients-with-acute-ischemic-stroke-100337146",false,"NCT03669653","Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Ischemic Stroke","SERIC-AIS","Inclusion Criteria:\n\n* 1）Age≥18 years, \\\u003C 80 years, regardless of sex；\n* 2）Patients with clinically definite diagnosis of acute ischemic stroke and able to commence RIC treatment within 12 hours of stroke onset\n* 3）Baseline NIHSS score\\>5, and≤25 ；\n* 4）GCS score ≥8；\n* 5）Signed and dated informed consent is obtained\n\nExclusion Criteria:\n\n* 1\\) Patients with suspected posterior circulation infarction；\n* 2\\) Patients who undergo thrombolytic therapy or endovascular treatment；\n* 3\\) mRS≥2 score before the onset of the disease；\n* 4\\) Double upper limbs or lower limbs paralysis was found in this case；\n* 5）Active bleeding of organs within 6 months of admission or current, including cerebral hemorrhage, subarachnoid hemorrhage, gastrointestinal hemorrhage, fundus hemorrhage and so on；\n* 6\\) Other intracranial lesions, such as cerebrovascular malformation cerebral venous diseases, tumor and other diseases involving the brain；\n* 7\\) Treated blood pressure ≤90mmHg\u002F60mmHg or≥180mmHg\u002F100mmHg；\n* 8\\) Severe organ dysfunction or failure；\n* 9\\) Persons suffering from severe hematological diseases or severe coagulation disorder dysfunction；\n* 10\\) Those who had a history of severe trauma or had major surgery within 6 months prior to admission；\n* 11\\) The patients who had the contraindication of remote ischemic conditioning treatment, such as severe soft tissue injury, fracture or vascular injury in the upper limb；Acute or subacute venous thrombosis, arterial occlusive disease, subclavian steal syndrome, etc；\n* 12\\) Pregnant or lactating women；\n* 13\\) Previous remote ischemic conditioning therapy or similar treatment；\n* 14\\) Patients with a life expectancy of less than 3 months or patients unable to complete the study for other reasons；\n* 15\\) Severe hepatic and renal dysfunction\n* 16\\) Unwilling to be followed up or treated for poor compliance；\n* 17\\) He\u002FShe is participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to admission；\n* 18\\) Other conditions that the researchers think are not suitable for the group.","ALL","18 Years","80 Years",{"count":71,"type":72},912,"ESTIMATED","INTERVENTIONAL",[75],"NA","he purpose of this study is to determine the efficacy and safety of remote ischemic conditioning for acute ischemic stroke.",[78],"Acute Ischemic Stroke","NOT_YET_RECRUITING","2024-10-01",{"date":82,"type":83},"2024-10-02","ACTUAL",{"date":85,"type":72},"2025-06-17",{"date":87,"type":72},"2026-09-20",{"name":58,"class":6},1]