[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100496351":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":47,"responsibleParty":48,"collaborators":47,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":47,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":47,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":73,"whyStopped":47,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":47},{"fullName":5,"class":6},"The First Hospital of Jilin University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Levofloxacin group","EXPERIMENTAL","Levofloxacin 200mg twice per day is administrated.",[13],"Drug: Levofloxacin",{"label":15,"type":16,"description":17,"interventionNames":18},"Levofloxacin simulant group","PLACEBO_COMPARATOR","Levofloxacin simulant 200mg twice per day is administrated.",[19],"Drug: Levofloxacin simulant",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Levofloxacin","Levofloxacin is a quinolone antibiotics and newly identified neuro-protective agent.Endovascular thrombectomy is one of the treatments for acute ischemic stroke.",[9],[27],"Endovascular thrombectomy",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Levofloxacin simulant","Levofloxacin simulant is placebo.Endovascular thrombectomy is one of the treatments for acute ischemic stroke.",[15],[27],[34],{"name":35,"affiliation":5,"role":36},"Yi Yang, MD,PhD","PRINCIPAL_INVESTIGATOR",[38,43],{"name":35,"role":39,"phone":40,"phoneExt":41,"email":42},"CONTACT","13756661217","0086","doctoryangyi@163.com",{"name":44,"role":39,"phone":45,"phoneExt":41,"email":46},"Zhenni Guo, MD,PhD","18186872986","zhen1ni2@163.com",null,{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":47,"oldOrganization":47},"SPONSOR_INVESTIGATOR","Yi Yang","Associated Dean of First Hospital of Jilin University","100496351","safety-and-efficacy-study-of-levofloxacin-combined-with-endovascular-thrombectomy-for-acute-ischemic-stroke-100496351",false,"NCT05743101","Safety and Efficacy Study of Levofloxacin Combined With Endovascular Thrombectomy for Acute Ischemic Stroke","Safety and Efficacy Study of Levofloxacin Combined With Endovascular Thrombectomy for Acute Ischemic Stroke Due to Large Vessel Occlusion of Anterior Circulation","Inclusion Criteria:\n\n1. Age 18-75 years.\n2. Patients with clinically confirmed acute ischemic stroke within 24 hours after onset, CTA or DSA confirmed anterior circulation large vessel occlusion (ICA, M1\u002Fproximal M2 segment of MCA, tandem lesions), met the current guidelines for emergency endovascular interventional therapy, and underwent emergency thrombectomy.\n3. mRS≤1 before stroke onset.\n4. Signed and dated informed consent is obtained.\n\nExclusion Criteria:\n\n1. Patients with contraindications to emergency thrombectomy;\n2. The head CT showed large facial cerebral infarction;\n3. Patients using glucocorticoids, antiarrhythmic drugs (class I and class III antiarrhythmic drugs: quinidine, procaine amine, lidocaine, phenytoin sodium, verapamil, etc.), and quinolones within 14 days;\n4. Patients with other diseases that may aggravate adverse drug reactions, such as ventricular arrhythmias, prolonged QT interval (male: QTc\\>430ms, female: QTc\\>450ms), severe cardiac insufficiency (NYHA functional grade ≥ III), myasthenia gravis, peripheral neuropathy, seizures, tendon-related diseases, severe immune system-related diseases, hematological diseases, active hepatitis or cirrhosis, serious respiratory diseases;\n5. Abnormal liver and kidney function: glutamic oxaloacetic transaminase or glutamic pyruvic transaminase exceeds 3 times the upper limit of normal; Direct bilirubin or indirect bilirubin more than 3 times the normal upper limit; Blood creatinine exceeds 1.1 times the upper limit of normal; Creatinine clearance rate≤50ml\u002Fmin; Urea nitrogen≥ 20mg\u002FdL;\n6. Fasting blood glucose lower than 3.9 mmol\u002FL;\n7. Patients allergy to fluoroquinolones or other antibiotics;\n8. Patients with a life expectancy less than 3 months or patients unable to complete the study for other reasons;\n9. Not willing to be followed up or poor treatment compliance;\n10. Patients who are participating in other clinical studies, or have participated in other clinical studies within 3 months before enrollment, or have participated in this study;\n11. Other conditions not suitable for enrollment.","ALL","18 Years","75 Years",{"count":63,"type":64},80,"ESTIMATED","INTERVENTIONAL",[67],"NA","The purpose of this study is to determine the efficacy and safety of levofloxacin combined with endovascular thrombectomy in treating acute ischemic stroke due to large vessel occlusion of anterior circulation.",[70],"Acute Ischemic Stroke",[72],"Endovascular thrombectomy, Levofloxacin","NOT_YET_RECRUITING","2024-10-01",{"date":76,"type":77},"2024-10-02","ACTUAL",{"date":79,"type":64},"2025-05-01",{"date":81,"type":64},"2026-07-01",{"name":50,"class":6}]