[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623339":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":45,"centralContacts":46,"locations":52,"responsibleParty":67,"collaborators":45,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":45,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":45,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":100,"whyStopped":45,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"The First Affiliated Hospital of Guangzhou Medical University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Conventional Chest Tube Drainage (CTD)","ACTIVE_COMPARATOR","Participants undergo uniportal VATS wedge resection followed by routine postoperative chest tube drainage. A chest tube is placed at the end of surgery and managed according to standard institutional protocols, including water seal or suction, criteria for tube removal, and discharge standards. This arm serves as the control group for comparison with tubeless strategies.",[13],"Procedure: Conventional Chest Tube Drainage",{"label":15,"type":16,"description":17,"interventionNames":18},"Single Intraoperative Aspiration Tubeless (SIA-Tubeless)","EXPERIMENTAL","Participants undergo uniportal VATS wedge resection and, after passing a standardized intraoperative water-seal air leak test, receive a single intraoperative negative-pressure aspiration of the pleural space under positive-pressure ventilation before chest closure. The catheter is completely removed intraoperatively, and no postoperative chest tube or aspiration is permitted.",[19],"Procedure: Single Intraoperative Aspiration Tubeless",{"label":21,"type":16,"description":22,"interventionNames":23},"Double Intraoperative Aspiration Tubeless (DIA-Tubeless)","Participants undergo uniportal VATS wedge resection and, after passing a standardized intraoperative water-seal air leak test, receive two consecutive intraoperative negative-pressure aspirations of the pleural space under positive-pressure ventilation before chest closure. After the second aspiration, the catheter is completely removed. No postoperative chest tube or aspiration is permitted.",[24],"Procedure: Double Intraoperative Aspiration Tubeless",[26,33,39],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"PROCEDURE","Conventional Chest Tube Drainage","After uniportal VATS wedge resection, a chest tube is routinely placed at the end of surgery for postoperative pleural drainage. Chest tube management, including water seal or suction, criteria for tube removal, and discharge standards, follows standard institutional protocols.",[9],[32],"CTD",{"type":27,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"Single Intraoperative Aspiration Tubeless","After uniportal VATS wedge resection and confirmation of no persistent air leak using a standardized intraoperative water-seal air leak test, a single negative-pressure aspiration of the pleural space is performed intraoperatively under positive-pressure ventilation before chest closure. The aspiration catheter is completely removed intraoperatively, and no postoperative chest tube or aspiration is allowed.",[15],[38],"SIA-Tubeless",{"type":27,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"Double Intraoperative Aspiration Tubeless","After uniportal VATS wedge resection and confirmation of no persistent air leak using a standardized intraoperative water-seal air leak test, two consecutive negative-pressure aspirations of the pleural space are performed intraoperatively under positive-pressure ventilation before chest closure. After the second aspiration, the catheter is completely removed. No postoperative chest tube or aspiration is permitted.",[21],[44],"DIA-Tubeless",null,[47],{"name":48,"role":49,"phone":50,"phoneExt":45,"email":51},"Yudong Zhang, MD","CONTACT","+86 13168266675","yudongz834@gmail.com",[53],{"facility":54,"status":45,"city":55,"state":45,"zip":45,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"The First Affiliated Hospital of GZMU","Guangzhou","China","CN",{"type":59,"coordinates":60},"Point",[61,62],113.25,23.11667,{"lat":62,"lon":61},[65],{"name":66,"role":49,"phone":50,"phoneExt":45,"email":51},"Yudong Zhang",{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":45,"oldOrganization":45},"PRINCIPAL_INVESTIGATOR","Jianxing He","Professor, Department of Thoracic Surgery","100623339","safety-and-recovery-of-tubeless-strategy-in-uniportal-vats-wedge-resection-100623339",false,"NCT07395349","Safety And Recovery Of Tubeless Strategy In Uniportal VATS Wedge Resection","Safety And Recovery Of Tubeless Strategy In Uniportal VATS Wedge Resection: A Single-Center, Prospective Randomized Controlled Study Based On Different Intraoperative Pleural Space Management Strategies","Inclusion Criteria:\n\n1. Age 18 to 80 years\n2. Scheduled to undergo uniportal video-assisted thoracoscopic (VATS) wedge resection\n3. Able to tolerate general anesthesia and single-lung ventilation\n4. Passed a standardized intraoperative water-seal air leak test, confirming absence of persistent air leak before chest closure\n5. Able and willing to provide written informed consent\n6. Able to complete postoperative assessments and 30-day follow-up\n\nExclusion Criteria:\n\n1. Planned anatomical lung resection (segmentectomy or lobectomy) or combined complex thoracic procedures\n2. Extensive pleural adhesions, severe emphysema, bullous lung disease, or other conditions associated with high risk of air leak\n3. Positive intraoperative air leak test indicating persistent air leak\n4. Requirement for additional intraoperative procedures that may significantly affect pleural air leak or lung re-expansion\n5. Conversion to multiport VATS or thoracotomy before randomization\n6. Severe comorbidities or other conditions deemed by the investigators to make participation inappropriate\n7. Inability to complete follow-up or insufficient clinical data","ALL","18 Years","80 Years",{"count":82,"type":83},300,"ESTIMATED","INTERVENTIONAL",[86],"NA","Brief Summary\n\nThe goal of this clinical trial is to evaluate the safety and recovery outcomes of different tubeless strategies in adult patients undergoing uniportal video-assisted thoracoscopic (VATS) wedge resection who are confirmed to have no persistent air leak intraoperatively.\n\nThe main questions it aims to answer are:\n\nDoes double intraoperative aspiration tubeless strategy reduce the rate of postoperative pleural re-intervention within 30 days compared with single intraoperative aspiration tubeless strategy?\n\nDo different intraoperative pleural space management strategies affect early postoperative recovery quality and pain?\n\nIf there is a comparison group:\n\nResearchers will compare conventional chest tube drainage, single intraoperative aspiration tubeless, and double intraoperative aspiration tubeless strategies to determine their effects on postoperative pleural re-intervention and recovery outcomes.\n\nParticipants will:\n\nUndergo uniportal VATS wedge resection\n\nReceive a standardized intraoperative air leak test before chest closure\n\nBe randomly assigned intraoperatively to one of three pleural space management strategies\n\nComplete postoperative assessments including chest imaging, pain evaluation, and recovery quality questionnaires\n\nBe followed for 30 days after surgery for safety outcomes",[89,90,91],"Pulmonary Nodule","Pneumothorax","Postoperative Complications",[93,94,95,96,97,98,99],"Uniportal VATS","Wedge Resection","Tubeless","Intraoperative Aspiration","Chest Tube Drainage","Enhanced Recovery After Surgery (ERAS)","Lung Re-expansion","NOT_YET_RECRUITING","2026-02-06",{"date":103,"type":104},"2026-02-09","ACTUAL",{"date":106,"type":83},"2026-02-28",{"date":108,"type":83},"2026-10-01",{"name":5,"class":6},1]