[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631209":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":52,"collaborators":25,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":25,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Universidad de Granada","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Saffron Extract","EXPERIMENTAL","Dietary Supplement: Saffron extract\n\nParticipants will receive 30 mg\u002Fday of standardized saffron extract (≥3% crocins; ≥2% safranal) for six weeks. Capsules will be taken once daily, one hour before bedtime.",[13],"Dietary Supplement: Saffron Extract",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Dietary Supplement: Placebo\n\nParticipants will receive identical capsules containing maltodextrin and excipients for six weeks, taken once daily one hour before bedtime.",[19],"Dietary Supplement: Dietary Supplement: Placebo",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Participants will receive 30 mg\u002Fday of standardized saffron extract (≥3% crocins; ≥2% safranal) for six weeks. Capsules will be taken once daily, one hour before bedtime.",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Dietary Supplement: Placebo","Participants will receive identical capsules containing maltodextrin and excipients for six weeks, taken once daily one hour before bedtime.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Lucas Jurado-Fasoli, PhD","CONTACT","+34618375662","juradofasoli@ugr.es",[37],{"facility":5,"status":38,"city":39,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Granada","18016","Spain","ES",{"type":44,"coordinates":45},"Point",[46,47],-3.60667,37.18817,{"lat":47,"lon":46},[50],{"name":51,"role":33,"phone":34,"phoneExt":25,"email":35},"Lucas Jurado Fasoli",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Lucas Jurado-Fasoli","PhD","100631209","saffron-extract-supplementation-and-sleep-quality-in-middle-aged-adults-100631209",false,"NCT07497698","Saffron Extract Supplementation and Sleep Quality in Middle-Aged Adults","Effects of Daily Saffron Extract Supplementation on Sleep Quality in Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial","SAFFRON-SLEEP","Inclusion Criteria:\n\n* Age 18-65 years\n* Mild-to-moderate sleep disturbances\n* BMI between 18 and 35 kg\u002Fm²\n* Not receiving active pharmacological or psychological treatment for sleep disorders\n* Willingness to comply with study procedures\n\nExclusion Criteria:\n\n* Severe neurological, psychiatric, or cardiovascular disorders\n* Diagnosed with obstructive sleep apnea, treated with CPAP\n* Night shift workers\n* Use of medications or supplements affecting sleep\n* Recreational drug use\n* Pregnancy or breastfeeding\n* Uncontrolled medical conditions",true,"ALL","18 Years","65 Years",{"count":69,"type":70},80,"ESTIMATED","INTERVENTIONAL",[73],"NA","This randomized, triple-blind, placebo-controlled clinical trial aims to evaluate the effects of daily saffron extract supplementation (30 mg\u002Fday) for six weeks on objective and subjective sleep quality in middle-aged adults with mild-to-moderate sleep disturbances. Secondary outcomes include heart rate variability, cognitive processing speed, emotional state, perceived health status, and biochemical stress markers.",[76],"Sleep",[78,79,80,81,82,83],"Saffron extract","Sleep quality","Insomnia","Actigraphy","Nutraceutical","Randomized clinical trial","2026-04-07",{"date":86,"type":87},"2026-04-13","ACTUAL",{"date":89,"type":87},"2026-03-01",{"date":91,"type":70},"2027-06-01",{"name":5,"class":6},1]