[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582886":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":34,"centralContacts":39,"locations":48,"responsibleParty":144,"collaborators":146,"id":153,"slug":154,"hasResults":155,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":155,"sex":161,"minAge":162,"maxAge":10,"enrollmentInfo":163,"targetDuration":166,"studyType":167,"phases":10,"briefSummary":168,"conditions":169,"keywords":175,"overallStatus":51,"whyStopped":10,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":189},{"fullName":5,"class":6},"Fondazione Don Carlo Gnocchi Onlus","OTHER",[8,14,18,22,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Alzheimer's Disease (AD)",null,"70 subjects.",[13],"Other: Saliva collection, longitudinal",{"label":15,"type":10,"description":16,"interventionNames":17},"Parkinson's Disease (PD)","70 subjects",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Atypical Parkinsonism (AtPD)","42 subjects comprehending people diagnosed with Multiple System Atrophy (MSA), Progressive Sopranuclear Palsy (PSP) and Corticobasal Degeneration (CBD).",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Prodromal Phase of Parkinson's Disease","30 subjects",[13],{"label":27,"type":10,"description":24,"interventionNames":28},"Mild Cognitive Impairment (MCI)",[13],[30],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"Saliva collection, longitudinal","1 ml of saliva will be collected with Salivette swabs. Subjects will undergo assessments and saliva sampling at enrollment time (T0) and one year after (T12).",[9,19,27,15,23],[35],{"name":36,"affiliation":37,"role":38},"Alice Gualerzi, PhD","IRCCS Fondazione Don Gnocchi","PRINCIPAL_INVESTIGATOR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":10,"email":44},"Pietro Arcuri, MD","CONTACT","+390240308833","parcuri@dongnocchi.it",{"name":36,"role":42,"phone":46,"phoneExt":10,"email":47},"+390240308533","agualerzi@dongnocchi.it",[49,73,84,113,127],{"facility":50,"status":51,"city":52,"state":53,"zip":10,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"IRCCS Don Gnocchi, Fondazione Don Gnocchi","RECRUITING","Florence","FI","Italy","IT",{"type":57,"coordinates":58},"Point",[59,60],11.24626,43.77925,{"lat":60,"lon":59},[63,67,68,71],{"name":64,"role":42,"phone":65,"phoneExt":10,"email":66},"Francesca Cecchi, MD","+390557393922","fcecchi@dongnocchi.it",{"name":64,"role":38,"phone":10,"phoneExt":10,"email":10},{"name":69,"role":70,"phone":10,"phoneExt":10,"email":10},"Cristina Polito","SUB_INVESTIGATOR",{"name":72,"role":70,"phone":10,"phoneExt":10,"email":10},"Alessio Faralli",{"facility":74,"status":51,"city":52,"state":10,"zip":10,"country":54,"countryCode":55,"cosmosGeoPoint":75,"geoPoint":77,"contacts":78},"Azienda Ospedaliero Universitaria Careggi Firenze",{"type":57,"coordinates":76},[59,60],{"lat":60,"lon":59},[79,82],{"name":80,"role":42,"phone":10,"phoneExt":10,"email":81},"Silvia Ramat, MD, PhD","silvia.ramat@unifi.it",{"name":83,"role":38,"phone":10,"phoneExt":10,"email":10},"Silvia Ramat",{"facility":85,"status":51,"city":86,"state":10,"zip":87,"country":54,"countryCode":55,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"IRCCS S. Maria Nascente, Fondazione Don Carlo Gnocchi ONLUS","Milan","20148",{"type":57,"coordinates":89},[90,91],9.18951,45.46427,{"lat":91,"lon":90},[94,95,96,97,99,101,103,105,107,109,111],{"name":36,"role":42,"phone":10,"phoneExt":10,"email":47},{"name":36,"role":38,"phone":10,"phoneExt":10,"email":10},{"name":41,"role":38,"phone":10,"phoneExt":10,"email":10},{"name":98,"role":70,"phone":10,"phoneExt":10,"email":10},"Marzia Bedoni, PhD",{"name":100,"role":70,"phone":10,"phoneExt":10,"email":10},"Silvia Picciolini, PhD",{"name":102,"role":70,"phone":10,"phoneExt":10,"email":10},"Francesca Lea Saibene, PhD",{"name":104,"role":70,"phone":10,"phoneExt":10,"email":10},"Luana Forleo",{"name":106,"role":70,"phone":10,"phoneExt":10,"email":10},"Aurora Mangolini",{"name":108,"role":70,"phone":10,"phoneExt":10,"email":10},"Anna Salvatore",{"name":110,"role":70,"phone":10,"phoneExt":10,"email":10},"Angelo Bellinvia",{"name":112,"role":70,"phone":10,"phoneExt":10,"email":10},"Sarah Feroldi",{"facility":114,"status":51,"city":86,"state":10,"zip":10,"country":54,"countryCode":55,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"IRCCS Istituto Neurologico \"Carlo Besta\"",{"type":57,"coordinates":116},[117,118],12.59836,42.78235,{"lat":118,"lon":117},[121,124,126],{"name":122,"role":42,"phone":10,"phoneExt":10,"email":123},"Gemma Lombardi","gemma.lombardi@istituto-besta.it",{"name":125,"role":38,"phone":10,"phoneExt":10,"email":10},"Giuseppe Di Fede",{"name":122,"role":70,"phone":10,"phoneExt":10,"email":10},{"facility":128,"status":51,"city":129,"state":10,"zip":10,"country":54,"countryCode":55,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"Centro S. Maria ai Servi, Fondazione Don Carlo Gnocchi Onlus","Parma",{"type":57,"coordinates":131},[132,133],10.32618,44.79935,{"lat":133,"lon":132},[136,139,140,142],{"name":137,"role":42,"phone":10,"phoneExt":10,"email":138},"Valerio Brambilla, MD","vbrambilla@dongnocchi.it",{"name":137,"role":38,"phone":10,"phoneExt":10,"email":10},{"name":141,"role":70,"phone":10,"phoneExt":10,"email":10},"Lorenzo Brambilla, MD",{"name":143,"role":70,"phone":10,"phoneExt":10,"email":10},"Beatrice Rizzi, MD",{"type":145,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[147,149,151],{"name":148,"class":6},"Fondazione Regionale per la Ricerca Biomedica",{"name":150,"class":6},"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta",{"name":152,"class":6},"Azienda Ospedaliero-Universitaria Careggi","100582886","saliva-and-extracellular-vesicles-for-neurodegenerative-diseases-100582886",false,"NCT06869135","Saliva and Extracellular Vesicles for Neurodegenerative Diseases","Novel Method for Diagnosis of Neurodegenerative Diseases Based on Saliva Biochemical Profiling","MINERVA","Inclusion Criteria:\n\n* AD: standard criteria for dementia due to AD with AD neurochemical demonstration.\n* PD: MDS Criteria; modified Hoehn\\&Yahr stages; stable pharmacological treatment (last 4 weeks).\n* AtP: current consensus diagnostic criteria for progressive supranuclear palsy; corticobasal degeneration and multiple system atrophy.\n* prodromic PD: according to diagnostic criteria by Berg;\n* MCI: according to diagnostic criteria by Dubois and Albert.\n\nExclusion Criteria:\n\n* For all the experimental groups considered, subjects with concomitant chronic and \u002F or inflammatory diseases of the oral cavity, other systemic diseases, oncological or infectious diseases will be excluded.\n* Patients not able to provide written informed consent autonomously will be excluded.\n* For PD patients: Vascular, familiar and drug- induced parkinsonism, other known or suspected causes (metabolic, brain tumor etc) or any suggestive features of AtP; dementia with MoCA Test Correct Score\\\u003C15","ALL","45 Years",{"count":164,"type":165},242,"ESTIMATED","12 Months","OBSERVATIONAL","Early diagnosis of Neurodegenerative diseases (NDDs) and accurate patient profiling are key goals needed to tailor prompt personalized therapeutic strategies that can significantly impact disease progression and patients' quality of life. The project will validate a novel, cost-effective and quick biophotonic-based method for early and differential diagnosis of NDDs (Parkinson's disease, atypical parkinsonisms, Alzheimer's disease) and for routine clinical monitoring of NDD progression (longitudinal study). Raman spectroscopy (RS) will be applied to biochemically profile saliva and salivaderived Extracellular Vesicles (sEVs) and to identify a spectroscopic biomarker for NDDs. Optimized protocols for RS will be used to concomitantly evaluate saliva and sEVs from people with NDDs and to detect salivary changes in the biochemical profile, with special focus on EV-associated components. The accuracy of the method in discriminating NDDs at different disease stages and during disease progression will be verified. A nanotechnology-based biomolecular characterization of saliva and sEV will clarify the involvement of specific pathological molecules in NDDs progression.",[170,171,172,173,27,174],"Neurodegenerative Diseases","Parkinson Disease","Alzheimer Disease","Parkinsonism","Prodromal Parkinson's Disease",[176,177,178,179],"Saliva","Raman Spectroscopy","Extracellular Vesicles","Diagnosis","2025-08-04",{"date":182,"type":183},"2025-08-07","ACTUAL",{"date":185,"type":183},"2025-01-24",{"date":187,"type":165},"2027-12-15",{"name":5,"class":6},5]