[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622863":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":25,"responsibleParty":45,"collaborators":48,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":10,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Lokman Hekim University","OTHER_GOV",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"MIH Group",null,"Children aged 8 to 12 years diagnosed with molar incisor hypomineralization (MIH) according to the European Academy of Paediatric Dentistry (EAPD) criteria. Participants in this group undergo a routine clinical dental examination without any therapeutic intervention. Physiological stress parameters, including salivary cortisol levels, heart rate, and oxygen saturation, are assessed during the dental visit.",{"label":13,"type":10,"description":14,"interventionNames":10},"Control Group","Age- and sex-matched healthy children aged 8 to 12 years without a diagnosis of molar incisor hypomineralization. Participants undergo a routine clinical dental examination without any therapeutic intervention. Salivary cortisol levels, heart rate, and oxygen saturation are measured using the same protocol as applied to the MIH group.",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Hamide Comert, DDS, PhD","CONTACT","+90 538 024 63 30","hamide.comert@lokmanhekim.edu.tr",{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},"Merve Ozdemir, DDS, PhD","+90 543 670 26 94","merveozdemir@lokmanhekim.edu.tr",[26],{"facility":27,"status":28,"city":29,"state":29,"zip":30,"country":31,"countryCode":10,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Lokman Hekim University, Faculty of Dentistry","RECRUITING","Ankara","06510","Turkey (Türkiye)",{"type":33,"coordinates":34},"Point",[35,36],32.85427,39.91987,{"lat":36,"lon":35},[39,40,41,43],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},{"name":17,"role":42,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"name":22,"role":44,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"type":42,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Hamide Comert","Assistant Professor, Specialist in Pediatric Dentistry",[49],{"name":50,"class":51},"The Scientific and Technological Research Council of Turkey","OTHER","100622863","salivary-cortisol-levels-in-children-with-molar-incisor-hypomineralization-100622863",false,"NCT07389148","Salivary Cortisol Levels in Children With Molar Incisor Hypomineralization","Evaluation of Salivary Cortisol Levels and Physiological Stress Parameters in Children With Molar Incisor Hypomineralization: A Comparative Observational Study","Inclusion Criteria:\n\n* Children aged between 8 and 12 years.\n* Children diagnosed with molar incisor hypomineralization (MIH) according to the European Academy of Paediatric Dentistry (EAPD) criteria or healthy children without MIH.\n* Ability to cooperate sufficiently to complete the clinical dental examination and study procedures.\n* Written informed consent obtained from a parent or legal guardian.\n\nExclusion Criteria:\n\n* Presence of systemic, hormonal, or metabolic diseases.\n* Regular use of medications known to affect salivary cortisol levels or cardiovascular parameters (e.g., corticosteroids, beta-blockers).\n* History of systemic conditions that may influence stress response.\n* Refusal of participation by the child or parent\u002Flegal guardian.",true,"ALL","8 Years","12 Years",{"count":64,"type":65},90,"ESTIMATED","OBSERVATIONAL","Molar incisor hypomineralization (MIH) is a developmental condition that affects the enamel of permanent molars and incisors in children and may cause tooth sensitivity, discomfort, and difficulties during dental treatment. These problems can increase dental anxiety and lead to physiological stress responses during dental visits.\n\nThe purpose of this observational study is to evaluate physiological stress responses in children with MIH by measuring salivary cortisol levels, heart rate, and oxygen saturation, and to compare these findings with those of children without MIH. A total of 90 children aged 8 to 12 years will participate in the study, including 45 children diagnosed with MIH and 45 healthy control participants.\n\nParticipation involves no treatment or intervention beyond a routine clinical dental examination. Heart rate and oxygen saturation will be measured during the dental visit, and saliva samples will be collected immediately after the examination using a non-invasive method to assess cortisol levels. The results of this study may contribute to a better understanding of stress responses in children with MIH and support the development of more individualized and anxiety-sensitive dental care approaches.",[69],"Molar Incisor Hypomineralization",[71,72,73,74,75,76],"Molar incisor hypomineralization","Salivary cortisol","Dental anxiety","Physiological stress","Children","Pediatric dentistry","2026-02-06",{"date":79,"type":80},"2026-02-09","ACTUAL",{"date":82,"type":65},"2026-01-26",{"date":84,"type":65},"2026-04-26",{"name":5,"class":6},1]