[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603841":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":57,"collaborators":61,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":10,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":10,"enrollmentInfo":76,"targetDuration":10,"studyType":79,"phases":10,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Aydin Adnan Menderes University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Minor Recurrent Aphthous Stomatitis Patients",null,"Participants aged 18 years or older who have been clinically diagnosed with minor recurrent aphthous stomatitis (RAS) based on characteristic clinical features and medical history. The lesion must be round or oval, less than 5 mm in diameter, surrounded by an erythematous halo, and covered by a grayish-white pseudomembrane. Eligible patients must have experienced at least three episodes of RAS within the past year and present with at least one aphthous ulcer at the time of clinical examination and saliva collection.",[13],"Diagnostic Test: ELISA",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy Controls","Participants aged 18 years or older with no lifetime history of recurrent aphthous stomatitis. Control group participants will be selected to match the patient group in terms of age and gender distribution. At the time of saliva collection, no aphthous lesions or any active oral mucosal pathology should be present.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","ELISA","Unstimulated saliva samples will be non-invasively collected from participants in this study to measure the concentrations of E-cadherin, Calprotectin, and MMP-9. These protein concentrations will be quantified using commercially available Enzyme-Linked Immunosorbent Assay (ELISA) kits.",[15,9],[25],{"name":26,"affiliation":5,"role":27},"Selin Yeşiltepe, dds,msd","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Sunay Hoşgör, dds","CONTACT","+905313636708","sunayhosgor@gmail.com",{"name":26,"role":31,"phone":35,"phoneExt":10,"email":36},"+905058282990","dt_selin@yahoo.com",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":10,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Aydın Adnan Menderes University","RECRUITING","Aydin","Efeler","09010","Turkey (Türkiye)",{"type":46,"coordinates":47},"Point",[48,49],27.83963,37.84501,{"lat":49,"lon":48},[52,53,54,55],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},{"name":26,"role":31,"phone":35,"phoneExt":10,"email":36},{"name":26,"role":27,"phone":10,"phoneExt":10,"email":10},{"name":30,"role":56,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Selin Yeşiltepe","Associate Professor",[62,65],{"name":63,"class":64},"Aydın Adnan Menderes University Scientific Research Projects Unit","UNKNOWN",{"name":5,"class":6},"100603841","salivary-e-cadherin-calprotectin-and-matrix-metalloproteinase-9-levels-in-recurrent-aphthous-stomatitis-100603841",false,"NCT07141758","Salivary E-cadherin, Calprotectin, and Matrix Metalloproteinase-9 Levels in Recurrent Aphthous Stomatitis","Investigation of Salivary E-cadherin, Calprotectin, and Matrix Metalloproteinase-9 Levels in Patients With Recurrent Aphthous Stomatitis","Inclusion Criteria:\n\n* Participants aged 18 years or older\n* Clinically diagnosed with minor recurrent aphthous stomatitis (RAS) (defined as having a history of at least three RAS episodes within the past year)\n* Systemically healthy (i.e., without any diagnosed systemic disease)\n* No history of tobacco use\n* Presence of at least one active aphthous ulcer at the time of saliva sample collection\n* No known mental or physical disabilities\n\nExclusion Criteria:\n\n* Use of any pharmacological treatment within the past 3 months\n* Use of antiseptic mouthwash within the past 3 months\n* Pregnant or lactating individuals, or those currently using oral contraceptives\n* History of systemic diseases associated with oral ulcerations such as Crohn's disease, ulcerative colitis, celiac disease, or Behçet's disease\n* History of chemotherapy or radiotherapy\n* Current or prior use of immunomodulatory drugs, cytotoxic agents, or systemic corticosteroids\n* Undergoing orthodontic treatment (to avoid misdiagnosis with traumatic ulcers)\n* Use of removable dental prostheses (to avoid misdiagnosis with traumatic ulcers)\n* Presence of periodontal disease (CPI score of 3 or 4)\n* Caries risk not classified as very low (DMFT ≥ 5)\n* Presence of pathological oral mucosal lesions such as lichen planus, pemphigus vulgaris, or mucous membrane pemphigoid",true,"ALL","18 Years",{"count":77,"type":78},102,"ESTIMATED","OBSERVATIONAL","The goal of this observational cross-sectional study is to determine the salivary levels of E-cadherin, Calprotectin, and Matrix Metalloproteinase-9 (MMP-9) in patients with Recurrent Aphthous Stomatitis (RAS) and to compare them with those of healthy controls.\n\nThe main questions it aims to answer are:\n\nAre the salivary levels of E-cadherin, Calprotectin, and MMP-9 significantly different in patients with minor RAS compared to healthy controls?\n\nCan these salivary proteins serve as biomarkers involved in the pathogenesis of minor RAS?\n\nResearchers will compare patients with minor RAS and healthy individuals to determine whether differences in salivary E-cadherin, Calprotectin, and MMP-9 levels are associated with the presence of disease.\n\nParticipants will:\n\nProvide unstimulated saliva samples using a saliva swab\n\nUndergo clinical evaluation for periodontal status (Community Periodontal Index - CPI) and caries experience (DMFT index)\n\nCollected saliva samples will be stored at -80°C until analysis. The concentrations of the investigated proteins will be measured using ELISA kits, and total protein levels will be determined using a colorimetric protein assay.\n\nThe relationships among the salivary concentrations of the investigated proteins, as well as their associations with demographic variables such as age and sex, will be analyzed.",[82,83],"Recurrent Aphthous Stomatitis","Aphthous Ulcer",[85,86,87,21,88,89,90,91],"E-cadherin","Calprotectin","MMP-9","Recurrent aphthous stomatitis","RAS","Saliva","Salivary Biomarkers","2025-08-25",{"date":94,"type":95},"2025-08-26","ACTUAL",{"date":97,"type":95},"2025-04-10",{"date":99,"type":78},"2026-06-30",{"name":59,"class":6},1]