[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100529112":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":22,"locations":31,"responsibleParty":47,"collaborators":10,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":10,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":10,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"ADHF",null,"Patients with ADHF (during admission and discharge).",{"label":13,"type":10,"description":14,"interventionNames":10},"CHF","Patients with CHF.",{"label":16,"type":10,"description":17,"interventionNames":10},"Control","Patients undergoing electrophysiology procedures.",[19],{"name":20,"affiliation":5,"role":21},"Michail Spanos, MD","STUDY_DIRECTOR",[23,28],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Saumya Das, MD, PhD","CONTACT","617-724-4500","sdas@mgh.harvard.edu",{"name":29,"role":25,"phone":10,"phoneExt":10,"email":30},"Priyanka Gokulnath, PhD","PGOKULNATH@mgh.harvard.edu",[32],{"facility":5,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-71.05977,42.35843,{"lat":43,"lon":42},[46],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Saumya Das","Director, Resynchronization and Advanced Cardiac Therapeutics Program, Massachusetts General Hospital; Associate Professor of Medicine, Harvard Medical School","100529112","salivary-extracellular-vesicle-associated-lncrnas-in-heart-failure-seal-hf-100529112",false,"NCT06169540","Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)","SEAL-HF","Inclusion Criteria CHF:\n\n* At least 18 years of age\n* Stable disease defined as CHF of any type, New York Heart Association (NYHA) functional class II\u002FIII\u002FIV, N-terminal pro-B-type natriuretic peptide (NT-proBNP) ≥600 pg\u002Fml if Left Ventricular Ejection Fraction (LVEF) ≤30%; ≥1000 pg\u002FmL if LVEF 31-35%; ≥2500 pg\u002FmL if EF \\>35%\n\nInclusion Criteria ADHF:\n\n* At least 18 years of age\n* Clinical signs and\u002For symptoms (including exertional or rest dyspnea, orthopnea or Paroxysmal Nocturnal Dyspnea (PND)) and N-terminal pro-BNP level \\> 1000 pg\u002FmL or BNP \\> 400 pg\u002Fml, OR Clinical evidence of congestion: X-ray evidence of pulmonary edema or pleural effusions, elevated Jugular Venous Pulse (JVP), lower extremity edema, or rales on pulmonary examination, right heart catheterization evidence of elevated filling pressures (Right Atrium (RA) pressure \\> 10 mmHg; Pulmonary Capillary Wedge Pressure (PCWP) \\> 18 mmHg) and clinical response to Intravenous (IV) diuretic therapy (as judged by a physician)\n\nInclusion Criteria control:\n\n* At least 18 years of age\n* Will\u002Fhave undergone an EP procedure in the EP lab\n\nExclusion Criteria:\n\n* Active pregnancy or lactation\n* Cardiac amyloidosis\n* Active malignancies","ALL","18 Years",{"count":61,"type":62},90,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to determine the relationship between the levels of Ribonucleic acid (RNA) circulating molecules, including ones in extracellular vesicles from different organs in the blood and in the saliva of patients with Acute Decompensated Heart Failure (ADHF) and Chronic Heart Failure (CHF) to see if a new, non-invasive diagnostic test can be developed for heart failure exacerbation.",[13,9,16],"2025-11-11",{"date":68,"type":69},"2025-11-13","ACTUAL",{"date":71,"type":69},"2023-04-19",{"date":73,"type":62},"2027-12-31",{"name":5,"class":6},1]