[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601885":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":21,"centralContacts":26,"locations":35,"responsibleParty":53,"collaborators":10,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":10,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":70,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":81,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Recep Tayyip Erdogan University Training and Research Hospital","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with normal or minor malocclusion",null,"Patients with a Dental Aesthetic Index score of ≤25",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients with moderate malocclusion","Patients with a Dental Aesthetic Index score of 26-30",{"label":16,"type":10,"description":17,"interventionNames":10},"Patients with severe malocclusion","Patients with a Dental Aesthetic Index score of 31-35",{"label":19,"type":10,"description":20,"interventionNames":10},"Patients with obstructive malocclusion","Patients with a Dental Aesthetic Index score of ≥36",[22],{"name":23,"affiliation":24,"role":25},"Oguz KOSE, Professor Dr.","Recep Tayyip Erdogan University Faculty of Dentistry","STUDY_DIRECTOR",[27,32],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},"Tuba KOSE, Assistant Professor","CONTACT","+90 0506 956 72 08","tuba.kose@erdogan.edu.tr",{"name":23,"role":29,"phone":33,"phoneExt":10,"email":34},"+90 0541 348 64 65","oguz.kose@erdogan.edu.tr",[36],{"facility":37,"status":10,"city":38,"state":39,"zip":40,"country":41,"countryCode":10,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Department of Orthodontics of the Faculty of Dentistry of Recep Tayyip Erdogan University","Rize","Rize Province","53200","Turkey (Türkiye)",{"type":43,"coordinates":44},"Point",[45,46],40.52194,41.02083,{"lat":46,"lon":45},[49],{"name":50,"role":29,"phone":51,"phoneExt":10,"email":52},"RTEU Faculty of Dentistry, Department of Orthodontics","+90 464 222 00 00","dis@erdogan.edu.tr",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dilek KARADOĞAN","Assoc. Prof. Dr.","100601885","salivary-stress-markers-associated-with-malocclusion-severity-100601885",false,"NCT07116317","Salivary Stress Markers Associated With Malocclusion Severity","Determination of the Relationship Between Orthodontic Malocclusion Severity and Salivary Cortisol, Dehydroepiandrosterone and Chromogranin A Levels","Inclusion Criteria:\n\n* Patients between the ages of 12 and 18,\n* Patients with all permanent teeth,\n* Patients with the ability to read and understand,\n* Patients with a cephalometric evaluation file and maxillary and mandibular impression dental models before diagnostic orthodontic treatment.\n\nExclusion Criteria:\n\n* Presence of any congenital craniofacial deformity (cleft lip and palate or any other craniofacial syndrome or deformity),\n* Patients who have previously initiated or completed orthodontic treatment,\n* Patients with a history of psychiatric illness, the presence of caries, facial asymmetry, and any skin deformity affecting facial aesthetics.","ALL","12 Years","18 Years",{"count":68,"type":69},120,"ESTIMATED","1 Day","OBSERVATIONAL","The aim of this observational study is to evaluate the relationship between the severity of orthodontic malocclusion and psychophysiological stress levels in individuals aged 12 to 18 years. The study will investigate the association between malocclusion severity and both stress-related salivary biomarkers and psychosocial factors.\n\nThe primary research question is as follows:\n\nAs the severity of orthodontic malocclusion increases, do levels of salivary stress biomarkers (cortisol, DHEA, and chromogranin A), self-esteem, and social appearance anxiety significantly change in adolescent individuals?\n\nMethod:\n\nThe study will include participants between the ages of 12 and 18. The severity of malocclusion will be assessed through clinical examination. Psychological assessments will be conducted using structured questionnaires to measure self-esteem and social appearance anxiety. In addition, saliva samples collected in the morning will be analyzed using the ELISA method to determine levels of cortisol, DHEA, and chromogranin A (CgA). The data will be statistically analyzed to identify the potential relationship between orthodontic malocclusion and biological and psychosocial indicators of stress.",[74],"Malocclusion",[76,77,78,79,80],"malocclusion","stress","cortisol","Dehydroepiandrosterone","Chromogranin A","NOT_YET_RECRUITING","2025-08-08",{"date":84,"type":85},"2025-08-11","ACTUAL",{"date":84,"type":69},{"date":88,"type":69},"2026-02-09",{"name":5,"class":6},1]