[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100546112":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":72,"collaborators":74,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":25,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":100,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"Natural Resources Institute Finland","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Microbial intervention","EXPERIMENTAL","Children receive an indoor sandbox and cultivation set including soil- and plant-based material with high microbial diversity.",[13],"Biological: Microbial intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"placebo","PLACEBO_COMPARATOR","Children receive an indoor sandbox and cultivation set including placebo material with low microbial diversity.",[19],"Other: Placebo",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BIOLOGICAL","Children in microbial intervention arm receive an indoor sandbox containing play sand enriched with organic leaf compost, moss and humus substances. Families also receive an indoor cultivation set including growing box, seeds, spray bottle, plant lamp and microbe rich growing medium containing organic leaf compost, moss, biochar and humus substances.",[9],null,{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":25},"OTHER","Placebo","Children in placebo arm receive an indoor sandbox containing visually similar play sand modified with peat with low microbial diversity. Families also receive an indoor cultivation set including growing box, seeds, spray bottle, plant lamp and growing medium containing peat, inorganic fertilizers, and potting gravel with low microbial diversity.",[15],[32],{"name":33,"affiliation":5,"role":34},"Aki Sinkkonen","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Sanna Hurtola","CONTACT","+358295322500","sanna.hurtola@luke.fi",[42,60],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Helsinki","Uusimaa","00970","Finland","FI",{"type":50,"coordinates":51},"Point",[52,53],24.93545,60.16952,{"lat":53,"lon":52},[56],{"name":57,"role":38,"phone":58,"phoneExt":25,"email":59},"Marja Roslund","+358295322256","marja.roslund@luke.fi",{"facility":61,"status":43,"city":62,"state":25,"zip":25,"country":47,"countryCode":48,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Tampere University","Tampere",{"type":50,"coordinates":64},[65,66],23.78712,61.49911,{"lat":66,"lon":65},[69],{"name":70,"role":38,"phone":25,"phoneExt":25,"email":71},"Laura Kummola, Phd","laura.kummola@tuni.fi",{"type":34,"investigatorFullName":33,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Lead Researcher",[75],{"name":61,"class":27},"100546112","sand-play---the-effect-of-biodiversity-exposure-on-atopic-dermatitis-100546112",false,"NCT06390696","Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis","Biodiversity Interventions for Well-being - the Effect of Biodiversity Exposure on Atopic Dermatitis","BIWE","Inclusion Criteria:\n\n* Eczema Area and Severity Index ≥ 2\n\nExclusion Criteria:\n\n* Eczema Area and Severity Index \\\u003C 2\n* Immune deficiencies, i.e., antibody deficiency\n* Immunosuppressive systematic medications\n* A disease affecting immune response (e.g., colitis ulcerosa, rheumatoid arthritis, Crohn's disease, diabetes)\n* Cancer diagnosis\n* Topical medication for the treatment of atopic dermatitis during the trial\n* Disability affecting the immune response (e.g. Down's syndrome)\n* Non-participation in the national vaccine program\n* Participation in another intervention or follow-up study",true,"ALL","2 Years","5 Years",{"count":89,"type":90},80,"ESTIMATED","INTERVENTIONAL",[93],"NA","The prevalence of atopic dermatitis has increased along with urbanization and biodiversity loss. According to biodiversity hypothesis, the main reason is urban lifestyle and reduced contact to microbial diversity. Previous studies indicate association between atopic dermatitis and exposure to natural microbes in childhood.\n\nSand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis will investigate whether the exposure to microbial diversity in sandbox reduces the symptoms of atopic dermatitis, alters commensal microbiota and modifies immune regulation in children.",[96,97,98,99],"Atopic Dermatitis","Nature, Human","Microbial Colonization","Immune System and Related Disorders",[101,102,103,104],"Atopy","Biodiversity","Commensal microbiota","Microbial exposure","2024-04-25",{"date":107,"type":108},"2024-04-30","ACTUAL",{"date":110,"type":108},"2023-05-26",{"date":112,"type":90},"2027-09-30",{"name":5,"class":6},2]