[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100497731":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":31,"responsibleParty":49,"collaborators":11,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":11,"enrollmentInfo":61,"targetDuration":11,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":33,"whyStopped":11,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Azienda Ospedaliero-Universitaria Careggi","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"A","EXPERIMENTAL",null,[13],"Radiation: RT",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"RADIATION","RT","The treatment will be administered in 25 daily fractions (Monday-Friday) at the disease site to include the region of suspected micrometastatic spread (Clinical Target Volume 1, CTV1) at a dose of 50 Gy (2Gy\n\n\u002F fraction) with SIB intensification on volume reduced corresponding to the interface sites between the tumor and the vascular \u002F nerve axes (Clinical Target Volume 2, CTV2) at a dose of 60 Gy (2.4 Gy \u002F fraction). The association with neoadjuvant chemotherapy based on anthracyclines is allowed.",[9],[21],{"name":22,"affiliation":23,"role":24},"lorenzo livi, Dr","AOU Careggi","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":11,"email":30},"Marta Pacinico","CONTACT","0557947192","marta.pacinico@unifi.it",[32],{"facility":23,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Florence","Fi","50134","Italy","IT",{"type":40,"coordinates":41},"Point",[42,43],11.24626,43.77925,{"lat":43,"lon":42},[46,48],{"name":47,"role":28,"phone":29,"phoneExt":11,"email":30},"lorenzo livi",{"name":27,"role":28,"phone":29,"phoneExt":11,"email":11},{"type":24,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Lorenzo Livi","Professor","100497731","sarcoma-preoperative-radiation-with-simultaneous-integrated-boost-sprint-100497731",false,"NCT05761054","Sarcoma Preoperative Radiation With Simultaneous INTegrated Boost (SPRINT)","SPRINT","Inclusion Criteria:\n\n* Patients aged ≥ 18 years\n* Confirmed histological diagnosis of soft tissue sarcoma\n* Candidate for conservative surgery\n* Performance status ≤ 1 according to WHO (or ≥ 70 according to KPS) before starting the treatment in the office.\n\nExclusion Criteria:\n\n* Previous radiotherapy at the same site\n* Candidate for Surgical Amputation\n* Patients with comorbidities for collagen diseases\n* Psychiatric disorders that may preclude obtaining the informed consent","ALL","18 Years",{"count":62,"type":63},33,"ESTIMATED","INTERVENTIONAL",[66],"NA","Intervention prospective monocentric one arm study on the use of neoadjuvant radiotherapy with simultaneous integrated boost (Simultaneous Integrated Boost, SIB) in patients with STS with indication for preoperative radiotherapy. The treatment will be administered in 25 daily fractions (Monday-Friday) at the disease site to include the region of suspected micrometastatic spread (Clinical Target Volume 1, CTV1) at a dose of 50 Gy (2Gy\n\n\u002F fraction) with SIB intensification on volume reduced corresponding to the interface sites between the tumor and the vascular \u002F nerve axes (Clinical Target Volume 2, CTV2) at a dose of 60 Gy (2.4 Gy \u002F fraction). The association with neoadjuvant chemotherapy based on anthracyclines is allowed.",[69],"Soft Tissue Sarcoma",[71,72,73,74,75],"soft tissue sarcoma (STS)","Intensity Modulated Radiotherapy (IMRT)","boost","radiotherapy","locally advanced soft tissue sarcoma","2023-02-27",{"date":78,"type":79},"2023-03-09","ACTUAL",{"date":81,"type":79},"2022-07-19",{"date":83,"type":63},"2027-07-01",{"name":5,"class":6},1]