[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634146":3},{"organization":4,"armGroups":7,"interventions":45,"overallOfficials":64,"centralContacts":68,"locations":73,"responsibleParty":90,"collaborators":93,"id":99,"slug":100,"hasResults":101,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":51,"eligibilityCriteria":105,"healthyVolunteers":101,"sex":106,"minAge":107,"maxAge":51,"enrollmentInfo":108,"targetDuration":51,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":120,"overallStatus":124,"whyStopped":51,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":134},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,17,21,25,29,33,37,41],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1: WLM Program + Mom's Meals + YMCA + SKY","ACTIVE_COMPARATOR","Eight participants will be assigned to the foundational WLM program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive three candidate support components: (1) medically tailored meals (Mom's Meals), (2) YMCA membership to support physical activity, and (3) the SKY Meditation program to support mind-based practices.",[13,14,15,16],"Behavioral: Weight Loss Maintenance Program (Foundational)","Behavioral: Mom's Meals","Behavioral: YMCA Membership","Behavioral: SKY Meditation Program",{"label":18,"type":10,"description":19,"interventionNames":20},"Group 2: WLM Program + Mom's Meals + YMCA","Eight Participants will be assigned to the foundational program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive two candidate support components: (1) medically tailored meals (Mom's Meals), (2) YMCA membership to support physical activity.",[13,14,15],{"label":22,"type":10,"description":23,"interventionNames":24},"Group 3: WLM Program + Mom's Meals + SKY","Eight Participants will be assigned to the foundational program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive candidate support components: (1) medically tailored meals (Mom's Meals), and (3) the SKY Meditation program to support mind-based practices.",[13,14,16],{"label":26,"type":10,"description":27,"interventionNames":28},"Group 4: WLM Program + Mom's Meals","Eight Participants will be assigned to the foundational program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive candidate support components: (1) medically tailored meals (Mom's Meals).",[13,14],{"label":30,"type":10,"description":31,"interventionNames":32},"Group 5: WLM Program + YMCA + SKY","Eight Participants will be assigned to the foundational program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive candidate support components: (2) YMCA membership to support physical activity, and (3) the SKY Meditation program to support mind-based practices.",[13,15,16],{"label":34,"type":10,"description":35,"interventionNames":36},"Group 6: WLM Program + YMCA","Eight Participants will be assigned to the foundational program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive support components: (2) YMCA membership to support physical activity.",[13,15],{"label":38,"type":10,"description":39,"interventionNames":40},"Group 7: WLM Program + SKY","Eight Participants will be assigned to the foundational program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive support components: (3) the SKY Meditation program to support mind-based practices.",[13,16],{"label":42,"type":10,"description":43,"interventionNames":44},"Group 8: Foundational WLM Program Only","Eight participants will receive the 10-week foundational program. One group (n=8) will receive only the foundational program without any additional components.",[13],[46,52,56,60],{"type":47,"name":48,"description":49,"armGroupLabels":50,"otherNames":51},"BEHAVIORAL","Weight Loss Maintenance Program (Foundational)","All participants will receive a standardized 10-week foundational weight loss maintenance program designed to address three key domains: food, physical activity, and mind-based practices. This foundational program is intended to support the transition from active weight loss to long-term weight maintenance.",[9,18,22,26,30,34,38,42],null,{"type":47,"name":53,"description":54,"armGroupLabels":55,"otherNames":51},"Mom's Meals","Medically tailored meals",[9,18,22,26],{"type":47,"name":57,"description":58,"armGroupLabels":59,"otherNames":51},"YMCA Membership","YMCA membership to support physical activity",[9,18,30,34],{"type":47,"name":61,"description":62,"armGroupLabels":63,"otherNames":51},"SKY Meditation Program","The SKY Meditation program to support mind-based practices",[9,22,30,38],[65],{"name":66,"affiliation":5,"role":67},"Holly Wyatt, MD","PRINCIPAL_INVESTIGATOR",[69],{"name":66,"role":70,"phone":71,"phoneExt":51,"email":72},"CONTACT","303-378-6720","drholly@uab.edu",[74],{"facility":5,"status":51,"city":75,"state":76,"zip":77,"country":78,"countryCode":79,"cosmosGeoPoint":80,"geoPoint":85,"contacts":86},"Birmingham","Alabama","35294","United States","US",{"type":81,"coordinates":82},"Point",[83,84],-86.80249,33.52066,{"lat":84,"lon":83},[87,89],{"name":66,"role":70,"phone":88,"phoneExt":51,"email":72},"205-975-6270",{"name":66,"role":67,"phone":51,"phoneExt":51,"email":51},{"type":67,"investigatorFullName":91,"investigatorTitle":92,"investigatorAffiliation":5,"oldNameTitle":51,"oldOrganization":51},"Holly Wyatt","Professor",[94,97],{"name":95,"class":96},"National Institutes of Health (NIH)","NIH",{"name":98,"class":96},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","100634146","scalable-behavioral-program-for-weight-loss-maintenance-after-glp-1-and-anti-obesity-medication-discontinuation-100634146",false,"NCT07535892","Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation","Pilot Trial of a Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation","Inclusion Criteria:\n\n* Age 18 years or older\n* Loss of ≥15% of initial body weight using anti-obesity medication\n* Discontinued anti-obesity medication within the past 4 weeks or planning to discontinue prior to randomization\n* ≤3 kg weight regain within the past 3 months\n* Willing and able to participate in a 6-month behavioral intervention, including a 10-week foundational program\n* Willing to complete study assessments at baseline, 3 months, and 6 months, including required in-person visits\n* Medical clearance for participation in moderate physical activity, dietary modification, and mind-based practices\n* Access to reliable internet for participation in virtual sessions and remote data collection\n* English fluency sufficient to complete study procedures\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Medical conditions that would preclude safe participation in physical activity, dietary changes, or mind-based practices (e.g., unstable cardiovascular disease, uncontrolled hypertension, severe orthopedic limitations, or seizure disorders not medically managed)\n* Active psychiatric conditions that would interfere with participation or safety (e.g., untreated major depression, active substance use disorder, or psychosis)\n* Pregnancy, breastfeeding, or plans to become pregnant during the study period\n* Current participation in another structured weight loss or weight maintenance program\n* Continued use of anti-obesity medication after randomization\n* Plans to initiate medications or treatments that may significantly affect body weight during the study period\n* Inability to attend required study visits or participate in virtual sessions and remote data collection\n* Any condition that, in the opinion of the investigators, would compromise participant safety or study integrity","ALL","18 Years",{"count":109,"type":110},64,"ESTIMATED","INTERVENTIONAL",[113],"NA","This study is a single-site, pilot randomized factorial trial designed to evaluate the feasibility, acceptability, participant perceptions and preliminary effects of a multi-component behavioral intervention to support weight loss maintenance following discontinuation of GLP-1 and other anti-obesity medications. The intervention includes a standardized 10-week foundational weight loss maintenance program combined with candidate support components, including medically tailored meals, YMCA membership, and a structured mind-based program. Participants will be randomized using a 2 × 2 × 2 factorial design and followed for six months. Findings from this pilot study will inform optimization of a scalable intervention for future clinical trials.",[116,117,118,119],"Weight Loss","GLP - 1","Weight Loss Maintenance","Obesity & Overweight",[116,121,122,123],"GLP-1","Anti-Obesity Medication","weight loss maintenance","NOT_YET_RECRUITING","2026-06-23",{"date":127,"type":128},"2026-06-26","ACTUAL",{"date":130,"type":110},"2026-11-01",{"date":132,"type":110},"2029-07-31",{"name":5,"class":6},1]