[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571439":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":23,"locations":29,"responsibleParty":61,"collaborators":65,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":18,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":32,"whyStopped":18,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Insel Gruppe AG, University Hospital Bern","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"School nurse program","EXPERIMENTAL","The experimental intervention consists in a school nurse program providing integrated health care through diagnosis, intervention, and follow-up of group A beta-hemolytic streptococcal pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with rheumatic heart disease.",[13],"Other: School nurse program",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of care","NO_INTERVENTION","No school nurse prorgam.",null,[20],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":18},"The intervention consists in the introduction of a school-nurse program providing health care through education about rheumatic heart disease, assessment, intervention, and follow-up of group A beta-hemolytic streptococcal pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with rheumatic heart disease.",[9],[24],{"name":25,"role":26,"phone":27,"phoneExt":18,"email":28},"Thomas Pilgrim Bern University Hospital, Bern, Switzerland","CONTACT","+41 31 632 08 27","thomas.pilgrim@insel.ch",[30,48],{"facility":31,"status":32,"city":33,"state":18,"zip":18,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"National Academy od Medical Sciences","RECRUITING","Kathmandu","Nepal","NP",{"type":37,"coordinates":38},"Point",[39,40],85.3206,27.70169,{"lat":40,"lon":39},[43,45],{"name":44,"role":26,"phone":18,"phoneExt":18,"email":18},"Kunjang Shrestha, MD",{"name":46,"role":47,"phone":18,"phoneExt":18,"email":18},"Poonam Sharma, MD","PRINCIPAL_INVESTIGATOR",{"facility":49,"status":32,"city":50,"state":18,"zip":18,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"Centre of Infectious Disease Research","Lusaka","Zambia","ZM",{"type":37,"coordinates":54},[55,56],28.28713,-15.40669,{"lat":56,"lon":55},[59],{"name":60,"role":26,"phone":18,"phoneExt":18,"email":18},"Guy K Muula",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","Thomas Pilgrim","MD, MSc",[66,69,72],{"name":67,"class":68},"Centre for Infectious Disease Research in Zambia (CIDRZ)","UNKNOWN",{"name":70,"class":71},"National Academy of Medical Sciences, Nepal","OTHER_GOV",{"name":73,"class":6},"University of Oxford","100571439","school-based-program-for-the-prevention-of-rheumatic-heart-disease-in-endemic-regions-100571439",false,"NCT06720272","School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions","Effectiveness of an Integrated Program for the Prevention of Rheumatic Heart Disease in Endemic Regions: a Stepped Wedge Cluster Randomized Trial","PREVENT","Inclusion Criteria:\n\n\\- Children aged 5-16 years\n\nExclusion Criteria:\n\n* Children \u002F primary caregivers not providing informed consent to participate\n* Children not attending one of the selected schools",true,"ALL","5 Years","16 Years",{"count":87,"type":88},6000,"ESTIMATED","INTERVENTIONAL",[91],"NA","The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD.\n\nWe conduct a stepped wedge cluster randomized trial in randomly selected schools in Nepal and Zambia.\n\nThe intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about RHD, assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with RHD.",[94],"Rheumatic Heart Disease in Children",[96,97,98,99,100],"rheumatic heart disease","valvular heart disease","prevention","streptococcal pharyngitis","rheumatic fever","2026-01-16",{"date":103,"type":104},"2026-01-20","ACTUAL",{"date":106,"type":104},"2024-12-15",{"date":108,"type":88},"2028-02",{"name":63,"class":6},2]