[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571439":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":13,"armGroups":23,"interventions":34,"overallOfficials":13,"centralContacts":38,"locations":44,"responsibleParty":76,"collaborators":80,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":98,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":13,"studyType":104,"phases":105,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":47,"whyStopped":13,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":125},{"fullName":5,"class":6},"Insel Gruppe AG, University Hospital Bern","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Rheumatic heart disease","The primary outcome of the study will be the reduction in prevalence of rheumatic heart disease according to WHF criteria 2023 as assessed by systematic echocardiographic screening.","The endpoint will be assessed after a minimum of 1 and a maximum of 3 years after introduction of the school nurse program.",null,{"allocation":15,"interventionModel":16,"interventionModelDescription":17,"primaryPurpose":18,"observationalModel":13,"timePerspective":13,"maskingInfo":19},"RANDOMIZED","SEQUENTIAL","Stepped wedge cluster randomized trial","PREVENTION",{"masking":20,"maskingDescription":13,"whoMasked":21},"SINGLE",[22],"OUTCOMES_ASSESSOR",[24,30],{"label":25,"type":26,"description":27,"interventionNames":28},"School nurse program","EXPERIMENTAL","The experimental intervention consists in a school nurse program providing integrated health care through diagnosis, intervention, and follow-up of group A beta-hemolytic streptococcal pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with rheumatic heart disease.",[29],"Other: School nurse program",{"label":31,"type":32,"description":33,"interventionNames":13},"Standard of care","NO_INTERVENTION","No school nurse prorgam.",[35],{"type":6,"name":25,"description":36,"armGroupLabels":37,"otherNames":13},"The intervention consists in the introduction of a school-nurse program providing health care through education about rheumatic heart disease, assessment, intervention, and follow-up of group A beta-hemolytic streptococcal pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with rheumatic heart disease.",[25],[39],{"name":40,"role":41,"phone":42,"phoneExt":13,"email":43},"Thomas Pilgrim Bern University Hospital, Bern, Switzerland","CONTACT","+41 31 632 08 27","thomas.pilgrim@insel.ch",[45,63],{"facility":46,"status":47,"city":48,"state":13,"zip":13,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"National Academy od Medical Sciences","RECRUITING","Kathmandu","Nepal","NP",{"type":52,"coordinates":53},"Point",[54,55],85.3206,27.70169,{"lat":55,"lon":54},[58,60],{"name":59,"role":41,"phone":13,"phoneExt":13,"email":13},"Kunjang Shrestha, MD",{"name":61,"role":62,"phone":13,"phoneExt":13,"email":13},"Poonam Sharma, MD","PRINCIPAL_INVESTIGATOR",{"facility":64,"status":47,"city":65,"state":13,"zip":13,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Centre of Infectious Disease Research","Lusaka","Zambia","ZM",{"type":52,"coordinates":69},[70,71],28.28713,-15.40669,{"lat":71,"lon":70},[74],{"name":75,"role":41,"phone":13,"phoneExt":13,"email":13},"Guy K Muula",{"type":77,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"SPONSOR_INVESTIGATOR","Thomas Pilgrim","MD, MSc",[81,84,87],{"name":82,"class":83},"Centre for Infectious Disease Research in Zambia (CIDRZ)","UNKNOWN",{"name":85,"class":86},"National Academy of Medical Sciences, Nepal","OTHER_GOV",{"name":88,"class":6},"University of Oxford","100571439","school-based-program-for-the-prevention-of-rheumatic-heart-disease-in-endemic-regions-100571439",false,"NCT06720272","School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions","Effectiveness of an Integrated Program for the Prevention of Rheumatic Heart Disease in Endemic Regions: a Stepped Wedge Cluster Randomized Trial","PREVENT","Inclusion Criteria:\n\n\\- Children aged 5-16 years\n\nExclusion Criteria:\n\n* Children \u002F primary caregivers not providing informed consent to participate\n* Children not attending one of the selected schools",true,"ALL","5 Years","16 Years",{"count":102,"type":103},6000,"ESTIMATED","INTERVENTIONAL",[106],"NA","The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD.\n\nWe conduct a stepped wedge cluster randomized trial in randomly selected schools in Nepal and Zambia.\n\nThe intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about RHD, assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with RHD.",[109],"Rheumatic Heart Disease in Children",[111,112,113,114,115],"rheumatic heart disease","valvular heart disease","prevention","streptococcal pharyngitis","rheumatic fever","2026-01-16",{"date":118,"type":119},"2026-01-20","ACTUAL",{"date":121,"type":119},"2024-12-15",{"date":123,"type":103},"2028-02",{"name":78,"class":6},2]