[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100489489":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":33,"locations":42,"responsibleParty":63,"collaborators":25,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Johns Hopkins University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Scrambler therapy","EXPERIMENTAL","Scrambler Therapy is a non-invasive neuromodulation approach using superficial electrocardiogram (ECG) electrodes in paired channels on the involved dermatomes to send \"non-pain\" information along the existing nerve pathways, which can modify peripheral and central sensitization.",[13],"Device: Scrambler therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"TENS treatment","ACTIVE_COMPARATOR","Transcutaneous electrical nerve stimulation (TENS) is a battery-powered device which delivers low-voltage electrical current through superficial electrocardiogram (ECG) electrodes placed on the surface of the skin to provide pain relief.",[19],"Device: TENS treatment",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Superficial electrocardiogram (ECG) electrodes are placed on the dermatomes involved with pain, above the area of pain itself. Each treatment lasts 30-40 minutes or until pain relief is obtained.",[9],null,{"type":22,"name":15,"description":23,"armGroupLabels":27,"otherNames":25},[15],[29],{"name":30,"affiliation":31,"role":32},"Alexander Pantelyat, MD","Department of Neurology, Johns Hopkins School of Medicine","PRINCIPAL_INVESTIGATOR",[34,38],{"name":30,"role":35,"phone":36,"phoneExt":25,"email":37},"CONTACT","410-502-3290","apantel1@jhmi.edu",{"name":39,"role":35,"phone":40,"phoneExt":25,"email":41},"Maria Schmidt, CRNP","410-502-0133","mschmi61@jhmi.edu",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Johns Hopkins School of Medicine","RECRUITING","Baltimore","Maryland","21205","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-76.61219,39.29038,{"lat":55,"lon":54},[58,59,60],{"name":30,"role":35,"phone":36,"phoneExt":25,"email":37},{"name":39,"role":35,"phone":40,"phoneExt":25,"email":41},{"name":61,"role":62,"phone":25,"phoneExt":25,"email":25},"Thomas J Smith, MD","SUB_INVESTIGATOR",{"type":64,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100489489","scrambler-therapy-for-corticobasal-syndrome-associated-pain-100489489",false,"NCT05653778","Scrambler Therapy for Corticobasal Syndrome-Associated Pain","ST-CBS","Inclusion Criteria:\n\n* men and women, ≥50 years of age or older with CBS with an average daily pain rating of \\> 4 out of 10, using the following question from the Brief Pain Inventory: \"Please rate your pain by circling the one number that best describes your (abdominal) pain\u002Fdiscomfort on average over the past week. (Scale 0-10; 0= No pain, 10= Pain as bad as you can imagine)\n* English speakers or English proficiency\n* They must have a life expectancy \\> 90 days per their treating neurologist.\n* The patient must be able to understand the study regimen, its requirements, risks, and discomforts, and is able and willing to sign an informed consent form.\n\nExclusion Criteria:\n\n* Pregnant women, nursing women, women of childbearing potential or their sexual partners who are unwilling to employ adequate contraception (condoms, diaphragm, birth control pills, injections, intrauterine device, surgical sterilization, subcutaneous implants, abstinence, etc.). Other exclusions include the following:\n* Use of an investigational agent for pain control concurrently or within the past 30 days,\n* History of an allergic reaction or previous intolerance to transcutaneous electronic nerve stimulation;\n* Patients with implantable drug delivery systems, e.g. Medtronic Synchromed, baclofen pumps.\n* Patients with heart stents or metal implants such as pacemakers, automatic defibrillators, cochlear implants, aneurysm clips, vena cava clips and skull plates. (Metal implants for orthopedic repair, e.g. pins, clips, plates, cages, joint replacements are allowed).\n* Medical exclusions include: patients with a history of myocardial infarction or ischemic heart disease within the past six months; patients with history of epilepsy, brain damage, or symptomatic brain metastases; skin conditions such as open sores that would prevent proper application of the electrodes; or other medical or other condition(s) that in the opinion of the investigators might compromise the objectives of the study.","ALL","50 Years","89 Years",{"count":76,"type":77},25,"ESTIMATED","INTERVENTIONAL",[80],"NA","The goal of this pilot trial is to test whether scrambler therapy (ST) is an effective treatment for neuropathic pain in patients with corticobasal syndrome (CBS).\n\nThe main question it aims to answer is:\n\nWill ST reduce pain scores by at least 33% at one month in this pilot trial, justifying further multi-center trials?\n\nParticipants will:\n\n* be randomly assigned treatment from either transcutaneous electrical nerve stimulation (TENS) or ST for pain initially (eventually all patients will receive ST).\n* have superficial electrocardiogram (ECG) electrodes placed on the dermatomes involved with pain\n* obtain treatment lasting 30-40 minutes or until pain relief is obtained\n\nResearchers will compare patient's response to pain relief with TENS and ST to determine if ST is an effective treatment for central neuropathic pain.",[83,84,85],"Corticobasal Degeneration","Corticobasal Syndrome","Pain, Neuropathic",[83,87,88,89,90],"scrambler therapy","Corticobasal syndrome","neuropathic pain","neuropathy","2026-01-12",{"date":93,"type":94},"2026-01-13","ACTUAL",{"date":96,"type":94},"2024-04-05",{"date":98,"type":77},"2027-02",{"name":5,"class":6},1]