[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606365":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":48,"collaborators":50,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":20,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":20,"enrollmentInfo":62,"targetDuration":20,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Johns Hopkins University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Scrambler Therapy for Chronic Pancreatitis Pain","EXPERIMENTAL","Adults with chronic pancreatitis and refractory abdominal pain will receive Scrambler therapy. Scrambler Therapy is a non-invasive neuromodulation treatment designed to relieve chronic pain by transmitting \"non-pain\" electrical signals through the skin to the nervous system. The device generates 16 variable waveforms that mimic natural nerve impulses, creating patient-specific cutaneous electrostimulation. These signals are carried by afferent C-fibers and interpreted by the central nervous system as non-painful, thereby modulating pain perception rather than blocking it.",[13],"Device: Scrambler Therapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Scrambler Therapy","Adults with chronic pancreatitis and refractory abdominal pain will receive Scrambler Therapy, a non-invasive neuromodulation device. Electrodes are placed near the painful area to deliver \"non-pain\" signals aimed at reducing pain perception. Participants will complete 5-10 daily treatment sessions, each lasting 30-40 minutes, with pain ratings collected before and after sessions and follow-up assessments over 3 months.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Mahya Faghih","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","443-287-4680","mfaghih2@jh.edu",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Johns Hopkins Green Spring Station","RECRUITING","Baltimore","Maryland","21205","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-76.61219,39.29038,{"lat":43,"lon":42},[46],{"name":47,"role":27,"phone":28,"phoneExt":20,"email":29},"Mahya Faghih, MD",{"type":49,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[51],{"name":52,"class":6},"The National Pancreas Foundation","100606365","scrambler-therapy-in-chronic-pancreatitis-100606365",false,"NCT07174609","Scrambler Therapy in Chronic Pancreatitis","A Pilot Study of Scrambler Therapy for Painful Chronic Pancreatitis","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Diagnosis of chronic pancreatitis with refractory abdominal pain\n* Able to provide written informed consent in English\n* Sufficient English language ability to complete study questionnaires\n* Reliable and regular access to a phone for follow-up\n\nExclusion Criteria:\n\n* Unable or unwilling to provide written consent\n* History or presence of a significant medical or psychiatric condition that would interfere with study participation\n* Pregnant or lactating women\n* Coronary stents or implanted metallic\u002Felectrical devices (pacemaker, defibrillator, aneurysm clips)\n* History of epilepsy, traumatic brain injury, or myocardial infarction within the past 6 months\n* Skin conditions preventing electrode placement (e.g., open wounds)\n* Any condition that, in the investigator's opinion, places the participant at increased risk or prevents full compliance with study procedures","ALL","18 Years",{"count":63,"type":64},40,"ESTIMATED","INTERVENTIONAL",[67],"NA","The investigators will enroll adults with chronic pancreatitis who have persistent abdominal pain not relieved by standard treatments. This study will test the feasibility and effectiveness of Scrambler Therapy, a non-invasive FDA-cleared device that delivers \"non-pain\" electrical signals through the skin to retrain the brain's pain perception. Participants will undergo 5-10 treatment sessions and be followed for 3 months with standardized pain scores and quality-of-life assessments. The goal is to generate pilot data to support larger studies of Scrambler Therapy as a novel option for pancreatic pain.",[70,71,72],"Chronic Pain","Pancreatitis","Chronic Pancreatitis",[74,75,76,17,77],"chronic pain","Abdominal pain","chronic pancreatitis","Electrocutaneous analgesia","2025-09-11",{"date":80,"type":81},"2025-09-16","ACTUAL",{"date":83,"type":81},"2024-11-01",{"date":85,"type":64},"2026-12-01",{"name":5,"class":6},1]