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MD",{"facility":170,"status":171,"city":172,"state":173,"zip":174,"country":25,"countryCode":26,"cosmosGeoPoint":175,"geoPoint":179,"contacts":180},"UT Southwestern, Harold C. Simmons Comprehensive Cancer Center","NOT_YET_RECRUITING","Dallas","Texas","75390",{"type":28,"coordinates":176},[177,178],-96.80667,32.78306,{"lat":178,"lon":177},[181],{"name":182,"role":40,"phone":7,"phoneExt":7,"email":7},"Larry Anderson, MD",{"facility":184,"status":21,"city":185,"state":186,"zip":187,"country":25,"countryCode":26,"cosmosGeoPoint":188,"geoPoint":192,"contacts":193},"University of Utah, Huntsman Cancer Hospital","Salt Lake City","Utah","84112",{"type":28,"coordinates":189},[190,191],-111.89105,40.76078,{"lat":191,"lon":190},[194,198],{"name":195,"role":11,"phone":196,"phoneExt":7,"email":197},"Sharmilee Nuli","801-213-6203","sharmilee.nuli@hci.utah.edu",{"name":199,"role":40,"phone":7,"phoneExt":7,"email":7},"Amandeep Godara, MD",{"facility":201,"status":21,"city":202,"state":203,"zip":204,"country":25,"countryCode":26,"cosmosGeoPoint":205,"geoPoint":209,"contacts":210},"VCU Medical Center","Richmond","Virginia","23219",{"type":28,"coordinates":206},[207,208],-77.46026,37.55376,{"lat":208,"lon":207},[211,215],{"name":212,"role":11,"phone":213,"phoneExt":7,"email":214},"Tyler Phillips","804-828-9085","phillipst5@vcu.edu",{"name":216,"role":40,"phone":7,"phoneExt":7,"email":7},"Hashim Mann, MD",{"type":218,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[220],{"name":221,"class":222},"National Cancer Institute (NCI)","NIH","100544144","screening-for-al-amyloidosis-in-smoldering-multiple-myeloma-100544144",false,"NCT06365060","Screening for AL Amyloidosis in Smoldering Multiple Myeloma","Inclusion Criteria:\n\n* Patients 40 years of age and older\n* diagnosed with either Smoldering Multiple Myeloma or a Monoclonal Gammopathy\n* dFLC greater than 23 mg\u002FL\n* abnormal FLC ratio\n* If the patient has an eGFR less than 50 mL\u002Fmin\u002F1.73m2, the FLC ratio is inconsequential. The patient only needs to meet the age and dFLC criterion.\n\nExclusion Criteria:\n\n* Patients younger than 40 years of age are not eligible\n* Patients with a previous finding of amyloid in other biopsies will not be included\n* Adults unable to consent are not eligible, including the cognitively impaired Pregnant women, pregnant minors, minors (i.e., individuals who are not yet adults), wards of the state, non-viable neonates, neonates of uncertain viability, and prisoners are not eligible","ALL","40 Years",{"count":232,"type":233},400,"ESTIMATED","OBSERVATIONAL","In this multicenter study, we will recruit 400 patients 40 years of age or older at 15 centers with a diagnosis of smoldering multiple myeloma (SMM), a group of patients for whom standard of care is observation not treatment. The main goal of this study is to screen for the diagnosis of light-chain amyloidosis (AL) before the onset of symptomatic disease and to develop a training set for a likelihood algorithm.",[237],"Smoldering Multiple Myeloma",[239,240],"SMM","AL Amyloidosis","2025-08-01",{"date":243,"type":244},"2025-08-06","ACTUAL",{"date":246,"type":244},"2024-05-01",{"date":248,"type":233},"2029-02-27",{"name":5,"class":6},13]