[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604693":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":34,"responsibleParty":58,"collaborators":61,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":10,"enrollmentInfo":76,"targetDuration":79,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Muğla Sıtkı Koçman University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PRISm",null,"Patients with a post-bronchodilator FEV1\u002FFVC ratio ≥ 0.70, FEV1 \\\u003C 80",[13],"Diagnostic Test: Blood Sampling",{"label":15,"type":10,"description":16,"interventionNames":17},"Normal PFT","Patients with a post-bronchodilator FEV1\u002FFVC ratio ≥ 0.70, FEV1 ≥ 80",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Blood Sampling","For AAT Level: Residual serum from routine blood samples drawn for standard clinical care will be aliquoted into polypropylene cryotubes.\n\nFor Genetic Testing: A separate capillary blood sample will be obtained via finger prick using a sterile lancet and collected on a designated filter paper.",[15,9],[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Ozlem Sengoren Dikis, Associate Professor","CONTACT","+905073849700","ozlemsengoren@mu.edu.tr",{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},"sabri serhan olcay, Assistant Prof.","+905057578329","serhanolcay@mu.edu.tr",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":10,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Muğla Training and Research Hospital","RECRUITING","Muğla","Menteşe","48000","Turkey (Türkiye)",{"type":43,"coordinates":44},"Point",[45,46],28.3665,37.21807,{"lat":46,"lon":45},[49,52,55],{"name":50,"role":27,"phone":51,"phoneExt":10,"email":29},"ozlem sengoren dikis, associate prof.","+905373849700",{"name":53,"role":54,"phone":10,"phoneExt":10,"email":10},"Ozlen Sengoren Dikis, Associate Prof","PRINCIPAL_INVESTIGATOR",{"name":56,"role":57,"phone":10,"phoneExt":10,"email":10},"Sabri Serhan Olcay, Assistant Prof","SUB_INVESTIGATOR",{"type":54,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Ozlem Sengoren Dikis","Associate Professor",[62],{"name":63,"class":64},"PROGENIKA BIOPHARMA, A GRIFOLS Company","UNKNOWN","100604693","screening-for-alpha-1-antitrypsin-deficiency-in-patients-with-airway-obstruction-100604693",false,"NCT07152834","Screening for Alpha-1 Antitrypsin Deficiency in Patients With Airway Obstruction","Evaluation of the Relationship Between Dyspnoea and Functional Airway Obstruction in Alpha-1 Antitrypsin Deficiency: A Prospective, Case-Control, Analytical Study","AATD-SAO","Inclusion Criteria:\n\n* Achieve a post-bronchodilator FEV1\u002FFVC ratio of 70 or above in the respiratory function test.\n* Be able to speak and understand Turkish.\n* Have the mental and cognitive capacity to understand the questions asked.\n\nExclusion Criteria:\n\n* Renal dysfunction; acute inflammation; rheumatological, haematological, or liver diseases; COPD; asthma; bronchiectasis; and a history of malignancy.\n* Pregnant women and users of oral contraceptives.",true,"ALL","18 Years",{"count":77,"type":78},734,"ESTIMATED","1 Day","OBSERVATIONAL","Brief Summary:\n\nThis study aims to find out if a genetic condition called Alpha-1 Antitrypsin Deficiency (AATD) is more common in people who have shortness of breath and signs of airway obstruction on their breathing tests.\n\nAlpha-1 antitrypsin (AAT) is a protein that protects the lungs from damage. AATD is an inherited condition where the body does not make enough of this protein, which can lead to lung diseases like emphysema, especially in smokers.\n\nInvestigators hypothesize that low AAT levels or related genetic mutations may be a contributing factor to airway obstruction in patients complaining of shortness of breath.\n\nTo test this, investigators will recruit patients from our outpatient clinic who are being evaluated for shortness of breath and are having a standard breathing test (spirometry). Investigators will measure their AAT levels and test for the most common genetic mutations that cause AATD using a small blood sample. Investigators will then compare the AAT levels and genetic results between different groups of patients, such as smokers and non-smokers with and without airway obstruction. Investigators will also see if the severity of a patient's shortness of breath is related to their AAT levels.\n\nThe goal is to improve the detection of AATD in this patient population, which could lead to better diagnoses and specific treatments for those who have this condition.",[83],"Alpha 1-antitrypsin Deficiency (AATD)",[85,86,9],"Alpha 1-Antitrypsin Deficiency","Airway Obstruction","2025-09-03",{"date":89,"type":90},"2025-09-10","ACTUAL",{"date":92,"type":90},"2025-08-06",{"date":94,"type":78},"2026-01-05",{"name":5,"class":6},1]