[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100228066":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":23,"locations":33,"responsibleParty":256,"collaborators":258,"id":261,"slug":262,"hasResults":263,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":267,"eligibilityCriteria":268,"healthyVolunteers":263,"sex":269,"minAge":270,"maxAge":18,"enrollmentInfo":271,"targetDuration":18,"studyType":274,"phases":275,"briefSummary":277,"conditions":278,"keywords":282,"overallStatus":36,"whyStopped":18,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":296},{"fullName":5,"class":6},"Imperial College London","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Diffusion Weighted MRI scan","EXPERIMENTAL","Patients who are enrolled in the study will undergo an additional diffusion weighted MRI (T2W, DWI and ADC sequences) of the liver.",[13],"Other: Diffusion Weighted MRI scan",[15],{"type":6,"name":9,"description":16,"armGroupLabels":17,"otherNames":18},"Liver metastases found on the additional DW-MRI scans will be discussed at MDT and treated according to local site policy.",[9],null,[20],{"name":21,"affiliation":5,"role":22},"Gina Brown","PRINCIPAL_INVESTIGATOR",[24,29],{"name":25,"role":26,"phone":27,"phoneExt":18,"email":28},"Caroline Martin","CONTACT","+44 (0) 7749 655 817","c.martin1@imperial.ac.uk",{"name":30,"role":26,"phone":31,"phoneExt":18,"email":32},"Syvella Ellis","+44 (0) 7732 315 234","giclinicaltrials@imperial.ac.uk",[34,57,74,90,106,122,138,154,175,191,207,226,242],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Macclesfield District General Hospital","RECRUITING","Macclesfield","Cheshire","SK10 3BL","United Kingdom","UK",{"type":43,"coordinates":44},"Point",[45,46],-2.12564,53.26023,{"lat":46,"lon":45},[49,52,55],{"name":50,"role":26,"phone":18,"phoneExt":18,"email":51},"Pippa Hill","philippahill@nhs.net",{"name":53,"role":26,"phone":18,"phoneExt":18,"email":54},"Lesley Wilkinson","lesley.wilkinson8@nhs.net",{"name":56,"role":22,"phone":18,"phoneExt":18,"email":18},"Chris Smart",{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":40,"countryCode":41,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Queen's Hospital","NOT_YET_RECRUITING","Burton-on-Trent","Derbyshire","DE13 0RB",{"type":43,"coordinates":64},[65,66],-1.64263,52.80728,{"lat":66,"lon":65},[69,72],{"name":70,"role":26,"phone":18,"phoneExt":18,"email":71},"Helena Cox","Helena.Cox@burtonft.nhs.uk",{"name":73,"role":22,"phone":18,"phoneExt":18,"email":18},"Manjusha Keni",{"facility":75,"status":36,"city":76,"state":77,"zip":78,"country":40,"countryCode":41,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Broomfield Hospital","Chelmsford","Essex","CM1 7ET",{"type":43,"coordinates":80},[81,82],0.46958,51.73575,{"lat":82,"lon":81},[85,88],{"name":86,"role":26,"phone":18,"phoneExt":18,"email":87},"Lauren Shillito","lauren.shillito@meht.nhs.uk",{"name":89,"role":22,"phone":18,"phoneExt":18,"email":18},"Peng Lee",{"facility":91,"status":36,"city":92,"state":93,"zip":94,"country":40,"countryCode":41,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"Royal Bolton Hospital","Bolton","Greater Manchester","BL4 0JR",{"type":43,"coordinates":96},[97,98],-2.43333,53.58333,{"lat":98,"lon":97},[101,104],{"name":102,"role":26,"phone":18,"phoneExt":18,"email":103},"Raksha Mistry","Raksha.mistry@boltonft.nhs.uk",{"name":105,"role":22,"phone":18,"phoneExt":18,"email":18},"Gemma Faulkner",{"facility":107,"status":36,"city":108,"state":109,"zip":110,"country":40,"countryCode":41,"cosmosGeoPoint":111,"geoPoint":115,"contacts":116},"Medway Maritime Hospital","Gillingham","Kent","ME7 5NY",{"type":43,"coordinates":112},[113,114],0.54863,51.38914,{"lat":114,"lon":113},[117,120],{"name":118,"role":26,"phone":18,"phoneExt":18,"email":119},"Suzie Rayner","Suzie.Reyner@medway.nhs.uk",{"name":121,"role":22,"phone":18,"phoneExt":18,"email":18},"Iheoma Amaechi",{"facility":123,"status":36,"city":124,"state":125,"zip":126,"country":40,"countryCode":41,"cosmosGeoPoint":127,"geoPoint":131,"contacts":132},"University Hospital of South Manchester & Manchester Royal Infirmary","Wythenshawe","Manchester","M23 9LT",{"type":43,"coordinates":128},[129,130],-2.2654,53.38027,{"lat":130,"lon":129},[133,136],{"name":134,"role":26,"phone":18,"phoneExt":18,"email":135},"Lindsay Piper","Lindsay.Piper@UHSM.NHS.UK",{"name":137,"role":22,"phone":18,"phoneExt":18,"email":18},"Sarah Duff",{"facility":139,"status":36,"city":140,"state":141,"zip":142,"country":40,"countryCode":41,"cosmosGeoPoint":143,"geoPoint":147,"contacts":148},"Royal Liverpool Hospital","Liverpool","Merseyside","L7 8XP",{"type":43,"coordinates":144},[145,146],-2.97794,53.41058,{"lat":146,"lon":145},[149,152],{"name":150,"role":26,"phone":18,"phoneExt":18,"email":151},"Matthew Noonan","Matthew.Noonan@rlbuht.nhs.uk",{"name":153,"role":22,"phone":18,"phoneExt":18,"email":18},"Catriona Farrell",{"facility":155,"status":36,"city":156,"state":157,"zip":158,"country":40,"countryCode":41,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"Royal Stoke University Hospital","Stoke-on-Trent","Staffordshire","ST4 6QG",{"type":43,"coordinates":160},[161,162],-2.18538,53.00415,{"lat":162,"lon":161},[165,169,173],{"name":166,"role":26,"phone":167,"phoneExt":18,"email":168},"Julie Storer","01782 672557","Julie.storer@uhnm.nhs.uk",{"name":170,"role":26,"phone":171,"phoneExt":18,"email":172},"Michelle Swann","01782 675859","Michelle.Swann@uhnm.nhs.uk",{"name":174,"role":22,"phone":18,"phoneExt":18,"email":18},"Ravivarma Balasubramaniam",{"facility":176,"status":36,"city":177,"state":178,"zip":179,"country":40,"countryCode":41,"cosmosGeoPoint":180,"geoPoint":184,"contacts":185},"Royal Marsden Hospital","Sutton","Surrey","SM2 5PT",{"type":43,"coordinates":181},[182,183],-0.2,51.35,{"lat":183,"lon":182},[186,189],{"name":187,"role":26,"phone":18,"phoneExt":18,"email":188},"Cordelia Grant","cordelia.grant@rmh.nhs.uk",{"name":190,"role":22,"phone":18,"phoneExt":18,"email":18},"Christos Kontovounisios",{"facility":192,"status":36,"city":193,"state":194,"zip":195,"country":40,"countryCode":41,"cosmosGeoPoint":196,"geoPoint":200,"contacts":201},"Royal Gwent Hospital","Newport","Wales","NP20 2UB",{"type":43,"coordinates":197},[198,199],-2.99835,51.58774,{"lat":199,"lon":198},[202,205],{"name":203,"role":26,"phone":18,"phoneExt":18,"email":204},"Heeam Nassa","Heeam.Nassa@wales.nhs.uk",{"name":206,"role":22,"phone":18,"phoneExt":18,"email":18},"Mark Robinson",{"facility":208,"status":36,"city":209,"state":210,"zip":211,"country":40,"countryCode":41,"cosmosGeoPoint":212,"geoPoint":216,"contacts":217},"George Eliot Hospital","Nuneaton","Warwickshire","CV10 7DJ",{"type":43,"coordinates":213},[214,215],-1.46523,52.52323,{"lat":215,"lon":214},[218,221,224],{"name":219,"role":26,"phone":18,"phoneExt":18,"email":220},"Pritpal Klear","Pritpal.Klear@geh.nhs.uk",{"name":222,"role":26,"phone":18,"phoneExt":18,"email":223},"Holly Lawrence","Holly.Lawrence@geh.nhs.uk",{"name":225,"role":22,"phone":18,"phoneExt":18,"email":18},"Jamal Abdulkarim",{"facility":227,"status":36,"city":228,"state":229,"zip":230,"country":40,"countryCode":41,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"Salisbury District Hospital","Salisbury","Wiltshire","SP2 8BJ",{"type":43,"coordinates":232},[233,234],-1.79569,51.06931,{"lat":234,"lon":233},[237,240],{"name":238,"role":26,"phone":18,"phoneExt":18,"email":239},"Ruth Casey","Ruth.Casey@salisbury.nhs.uk",{"name":241,"role":22,"phone":18,"phoneExt":18,"email":18},"Graham Branagan",{"facility":243,"status":36,"city":244,"state":18,"zip":18,"country":40,"countryCode":41,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"Queen Alexandra Hospital","Portsmouth",{"type":43,"coordinates":246},[247,248],-1.09125,50.79899,{"lat":248,"lon":247},[251,254],{"name":252,"role":26,"phone":18,"phoneExt":18,"email":253},"Nicola Gibbons","nicola.gibbons@porthosp.nhs.uk",{"name":255,"role":22,"phone":18,"phoneExt":18,"email":18},"Antony Higginson",{"type":257,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[259],{"name":260,"class":6},"Pelican Cancer Foundation","100228066","screening-for-synchronous-metastases-in-colorectal-cancer-with-dw-mri-serenade-100228066",false,"NCT02246634","Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE)","Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI.","SERENADE","Inclusion Criteria:\n\n1. Have a high risk primary colorectal malignancy\n2. Have a negative CT or includes no confirmatory evidence of liver metastases\n3. Is able to undergo treatment if liver metastasis is found\n4. Have provided written informed consent to participate in the study\n5. Be aged 16 years or over\n\nExclusion Criteria:\n\n1. Have had a previous colorectal malignancy\n2. Have metastatic disease\n3. Have a synchronous second malignancy\n4. Are contraindicated for MRI\n5. Has a T3b or below low rectal tumour without EMVI or N1c","ALL","16 Years",{"count":272,"type":273},282,"ESTIMATED","INTERVENTIONAL",[276],"NA","Eligible patients with high risk colorectal malignancy (T3\u002F4, spread greater than 5mm, EMVI positive) will have additional surveillance of breath hold T1, T2 and DW-MRIs (no IV contrast) post surgery six monthly for three years.\n\nFindings of liver MRIs as reported by radiology PI will be shared with their local MDT who make decisions as appropriate, including the management of any identified liver metastases, according to local protocol.",[279,280,281],"Colorectal Neoplasms","Neoplasm Metastases","Hepatic Neoplasms",[279,280,283,284,281,285,286],"Magnetic Resonance Imaging","Diffusion Weighted MRI","Tumors","Neoplasms, Rectal","2024-10-16",{"date":289,"type":290},"2024-10-17","ACTUAL",{"date":292,"type":290},"2014-08",{"date":294,"type":273},"2031-12",{"name":5,"class":6},13]