[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626017":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":26,"responsibleParty":46,"collaborators":26,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":26,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":26,"enrollmentInfo":58,"targetDuration":26,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":26,"overallStatus":69,"whyStopped":26,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":26},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Screw-Integrated Cage Group","EXPERIMENTAL","20 patients with cervical degenerative disc disease (CDDD) undergoing single or double-level ACDF using a cervical cage with integrated screw fixation.",[13],"Device: cervical cage with integrated screws",{"label":15,"type":16,"description":17,"interventionNames":18},"Traditional Cage Group","ACTIVE_COMPARATOR","20 patients with cervical degenerative disc disease (CDDD) undergoing single or double-level ACDF using a traditional standalone cervical cage",[19],"Device: traditional standalone cervical cage",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","cervical cage with integrated screws","Anterior Cervical Discectomy and Fusion (ACDF) procedure performed using a cervical cage that features integrated screw fixation. This device provides immediate biomechanical stability without the need for an additional anterior plate",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"traditional standalone cervical cage","Standard Anterior Cervical Discectomy and Fusion (ACDF) procedure using a traditional standalone interbody fusion cage (without integrated screws). This serves as the control intervention to compare stability and fusion rates",[15],[32],{"name":33,"affiliation":34,"role":35},"Mohamed Abdel-Hay El-Meshtawy","Assiut University, Faculty of Medicine, Orthopedic surgery and Traumatology.","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"momen mohamed Roshdy, MBBCH","CONTACT","00201129692785","moemenroshdy2016@gmail.com",{"name":43,"role":39,"phone":44,"phoneExt":26,"email":45},"Essam mohamed El-Morshidy, MD","00201119343404","esmorshidy@aun.edu.eg",{"type":35,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Momen Mohamed Roshdy Abdelaleem","Resident of Orthopedic Surgery and Traumatology","100626017","screw-integrated-vs-traditional-cervical-cages-in-acdf-for-degenerative-disc-disease-100626017",false,"NCT07430163","Screw-Integrated vs Traditional Cervical Cages in ACDF for Degenerative Disc Disease","Comparative Study Between Cervical Cage With Screws and Traditional Cage in Anterior Cervical Discectomy and Fusion (ACDF) for Treatment of Cervical Degenerative Disc Disease (CDDD)","Inclusion Criteria:\n\n* Patients aged above 18 years old.\n* Clinical diagnosis of cervical degenerative disc disease (CDDD).\n* Single or double level cervical degenerative disc disease (CDDD) confirmed by MRI\n* Failure of conservative treatment for at least 6 weeks.\n* Patients indicated for Anterior Cervical Discectomy and Fusion (ACDF).\n* Availability of complete preoperative and postoperative clinical and radiological data.\n* Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n* Previous cervical spine surgery.\n* Mutli-level (more than double level) cervical degenerative disc disease (CDDD).\n* Significant cervical instability requiring additional posterior fixation\n* Cervical trauma, fracture, or spinal infection.\n* Cervical tumors or inflammatory spinal disease.\n* Severe cervical deformity (fixed kyphosis)\n* Osteoporosis or metabolic bone disease.\n* Pregnancy\n* Psychiatric illness or substance abuse that would compromise follow-up","ALL","19 Years",{"count":59,"type":60},40,"ESTIMATED","INTERVENTIONAL",[63],"NA","This study is a prospective, comparative clinical trial conducted at Assiut University Hospitals to evaluate the effectiveness of two different interbody fusion devices in patients with Cervical Degenerative Disc Disease (CDDD). The primary objective is to compare cervical cages with integrated screws against traditional stand-alone cervical cages during single or double-level Anterior Cervical Discectomy and Fusion (ACDF). While ACDF is the gold standard for CDDD, traditional cages can sometimes lead to complications like subsidence or incomplete fusion; integrated screw designs aim to provide immediate stability and reduce these risks.\n\nInvestigators will assess 40 patients over a 12-month follow-up period, focusing on primary outcomes of radiological interbody fusion using the Daniel Riew grading system.\n\nSecondary outcomes include the maintenance of cervical alignment (Ishihara Index), change in segmental angles (Cobb's method), disc height restoration, and clinical improvements in pain and function measured by the Visual Analog Scale (VAS) and Neck Disability Index (NDI). The study's rationale is to provide clearer evidence on whether screw-integrated cages offer superior radiological and clinical outcomes to help guide future surgical preferences",[66,67,68],"Cervical Cage With Screw","Cervical Degenerative Disc Disease","Anterior Cervical Discectomy and Fusion (ACDF)","NOT_YET_RECRUITING","2026-02-18",{"date":72,"type":73},"2026-02-24","ACTUAL",{"date":75,"type":60},"2026-03-15",{"date":77,"type":60},"2027-12-30",{"name":5,"class":6}]