[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623420":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":29,"centralContacts":33,"locations":41,"responsibleParty":55,"collaborators":28,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":28,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":86,"whyStopped":28,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1: PCOS - Normoinsulinemic","EXPERIMENTAL","Description: Women with PCOS and normal insulin sensitivity Intervention: Blood sample collection for SCUBE-1 and SCUBE-3 measurement by ELISA",[13],"Diagnostic Test: Blood Sample Collection for SCUBE-1 and SCUBE-3 Measurement",{"label":15,"type":10,"description":16,"interventionNames":17},"Arm 2: PCOS - Hyperinsulinemic","Description: Women with PCOS and insulin resistance Intervention: Blood sample collection for SCUBE-1 and SCUBE-3 measurement by ELISA",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Arm 3: Healthy Controls","Description: Healthy women of reproductive age without PCOS Intervention: Blood sample collection for SCUBE-1 and SCUBE-3 measurement by ELISA",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DIAGNOSTIC_TEST","Blood Sample Collection for SCUBE-1 and SCUBE-3 Measurement","Blood sample collection performed specifically for research purposes to measure circulating SCUBE-1 and SCUBE-3 levels using enzyme-linked immunosorbent assay (ELISA).",[9,15,19],null,[30],{"name":31,"affiliation":5,"role":32},"Rosanna Apa, MD, PhD","PRINCIPAL_INVESTIGATOR",[34,38],{"name":31,"role":35,"phone":36,"phoneExt":28,"email":37},"CONTACT","+390630155872","rosanna.apa@policlinicogemelli.it",{"name":39,"role":35,"phone":36,"phoneExt":28,"email":40},"Anna Tropea, MD, PhD","anna.tropea@policlinicogemelli.it",[42],{"facility":5,"status":28,"city":43,"state":28,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Roma","00168","Italy","IT",{"type":48,"coordinates":49},"Point",[50,51],11.10642,44.99364,{"lat":51,"lon":50},[54],{"name":31,"role":35,"phone":36,"phoneExt":28,"email":37},{"type":56,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR","100623420","scube-proteins-in-polycystic-ovary-syndrome-ipsos-100623420",false,"NCT07396402","SCUBE Proteins in Polycystic Ovary Syndrome (IPSOS)","Study of Scube-1 and Scube-3 in Polycystic Ovary Syndrome (PCOS) and Their Possible Use as Inflammatory Markers and as a Link Between PCOS and Cardiovascular Events.","IPSOS","Inclusion Criteria:\n\n* Female subjects aged 18-35 years\n* Diagnosis of polycystic ovary syndrome (normoinsulinemic or hyperinsulinemic)\n* Availability of basal hormonal evaluation and oral glucose tolerance test\n* Healthy women for control group\n* Written informed consent\n\nExclusion Criteria:\n\n* Pregnancy\n* History of cardiovascular disease\n* Diabetes mellitus or impaired glucose tolerance\n* Hypertension\n* Significant hepatic or renal disease\n* Other endocrine disorders\n* Neoplastic diseases\n* Psychiatric disorders\n* Autoimmune diseases\n* Shift work\n* Obesity\n* Refusal to sign informed consent",true,"FEMALE","18 Years","35 Years",{"count":70,"type":71},56,"ESTIMATED","INTERVENTIONAL",[74],"NA","This study investigates circulating levels of SCUBE-1 and SCUBE-3 proteins in women with polycystic ovary syndrome (PCOS) compared with healthy controls. Differences between normoinsulinemic and hyperinsulinemic PCOS subgroups will be evaluated, as well as correlations with clinical and metabolic parameters related to inflammation and cardiovascular risk.",[77,78],"Polycystic Ovary Syndrome (PCOS)","Insulin Resistance",[80,81,82,83,78,84,85],"SCUBE-1","SCUBE-3","Polycystic Ovary Syndrome","PCOS","Inflammation","Cardiovascular Risk","NOT_YET_RECRUITING","2026-02-02",{"date":89,"type":90},"2026-02-09","ACTUAL",{"date":92,"type":71},"2026-01-15",{"date":94,"type":71},"2026-07-01",{"name":5,"class":6},1]