[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632093":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":35,"locations":45,"responsibleParty":71,"collaborators":18,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":18,"enrollmentInfo":85,"targetDuration":18,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":100,"whyStopped":18,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Semmelweis University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Central venous saturation guided transfusion","EXPERIMENTAL","Transfusion will be ordered and administered if ScvO2 is below 70%",[13],"Diagnostic Test: Measurement of central venous saturation",{"label":15,"type":16,"description":17,"interventionNames":18},"Clinician's decision (without ScvO2)","NO_INTERVENTION","Transfusion will be ordered and administered based on the treating physician's judgment without the knowledge of ScvO2",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DIAGNOSTIC_TEST","Measurement of central venous saturation","After randomisation central venous saturation will be measured. If the central venous saturation is below 70%, 1 unit of red blood cells will be transfused. The central venous saturation will be measured post transfusion, and if it is still below 70%, further 1 unit of RBCs will be transfused. Measurements and transfusions continue until ScvO2 reaches 70% or hemoglobin level increases above 9g\u002Fdl.\n\nIf ScvO2 is above 70%, no transfusion will be administered. ScvO2 will be measured again between 4-12 hours after the initial measurement. If it is still above 70%, no transfusion will be administered, and no further measurement will be performed on the given day.",[9],[26,29,31,33],{"name":27,"affiliation":5,"role":28},"Marton Papp, Dr","STUDY_CHAIR",{"name":30,"affiliation":5,"role":28},"Caner Turan, Dr",{"name":32,"affiliation":5,"role":28},"Dilan Mark Karim, Dr",{"name":34,"affiliation":5,"role":28},"Laszlo Zubek, Dr",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":18,"email":40},"Nikolett Kiss, Dr","CONTACT","+36204866809","kiss.nikolett@semmelweis.hu",{"name":42,"role":38,"phone":43,"phoneExt":18,"email":44},"Zsolt Molnar, Professor","+36303026668","molnar.zsolt1@semmelweis.hu",[46,60],{"facility":47,"status":18,"city":48,"state":18,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Semmelweis University, Department of Intensive Therapy","Budapest","1082","Hungary","HU",{"type":53,"coordinates":54},"Point",[55,56],19.04045,47.49835,{"lat":56,"lon":55},[59],{"name":37,"role":38,"phone":39,"phoneExt":18,"email":40},{"facility":61,"status":18,"city":48,"state":18,"zip":62,"country":50,"countryCode":51,"cosmosGeoPoint":63,"geoPoint":65,"contacts":66},"North-Pest Central Hospital- Hungarian Defense Forces Medical Center, Department of Anaesthesiology and Intensive Therapy","1134",{"type":53,"coordinates":64},[55,56],{"lat":56,"lon":55},[67],{"name":68,"role":38,"phone":69,"phoneExt":18,"email":70},"Peter Adam, Dr","+36302734033","peter.adam@epc-honvedkorhaz.hu",{"type":72,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Dr. Kiss Nikolett","Head of Central Intensive Care Unit","100632093","scvo2-centered-optimisation-of-red-blood-cell-transfusions-100632093",false,"NCT07509203","ScvO2-Centered Optimisation of RED Blood Cell Transfusions","ScvO2-Centered Optimisation of RED Blood Cell Transfusions (SCORED) - Protocol for a Multicenter, Randomised, Controlled Clinical Trial to Compare the Central Venous Saturation (ScvO2) Guided Transfusion Trigger Versus Transfusion Based on Clinician's Decision in the Critically Ill","SCORED","Inclusion Criteria:\n\n* Patient in medical\u002Fsurgical\u002Ftrauma ICU\n* Hemoglobin level between 7g\u002Fdl and 9g\u002Fdl\n* Written informed consent by patient or next of kin\n* Hemodynamically stable:\n\n  * CRT normal\n  * Serum lactate \\\u003C2 mmol\u002Fl\n  * MAP \\>65 mmHg\n  * noradrenalin \\\u003C 0,2 mcg\u002Fkg\u002Fmin and no increase in 6 hours\n  * No new ischemic change on ECG\n* Monitored with CVC, arterial catheter, hourly urine output\n* Respiratorily stable\n\n  * No support or\n  * Nasal canula\u002Fface mask O2 supplementation or\n  * NIV or\n  * Invasive mechanical ventillation: PC\u002FVC\u002FPS, PEEP\\\u003C 15 cmH2O FiO2 \\\u003C 50% and no increase in 6 hours\n* PiCCO or expert ECHO available within 48hours\n\nExclusion Criteria:\n\n* ScvO2\\>80%\n* Acid-base imbalance (pH\\\u003C7.3 or pH\\>7.5)\n* Chronic kidney disease (KDIGO Stage 3-4-5)\n* Acute heart failure (ESC 2021 definition)\n* Pregnancy\n* Active bleeding\n* Neurotrauma requiring intracranial pressure monitoring\n* Morbid obesity BMI \\>40\n* Horowitz Quotient (paO2\u002FFiO2) \\\u003C 200\n* Acute and chronic liver failure (Child-Pugh B,C)\n* Fever","ALL","18 Years",{"count":86,"type":87},600,"ESTIMATED","INTERVENTIONAL",[90],"NA","This clinical trial aims to personalise red blood cell transfusion strategies in the crtitically ill patients. The amount of transfusions needs to be minimised in order to prevent adverse events and organ dysfunctions linked to high amounts of red blood cell transfusions.\n\nThe researchers aim to investigate the efficacy and safety of measuring the central venous oxygen saturation (ScvO2) (oxygen content in a venous blood sample taken from a central line) to guide clinicians if transfusion is necessary.\n\nThe researchers aim to compare the ScvO2 guided transfusion strategy with transfusion based on the clinician's judgment (taking into consideration the patients' comorbidities and actual vital parameters).",[93],"Anaemia",[95,96,97,98,99],"central venous saturation","transfusion","critically ill","ICU","red blood cell","NOT_YET_RECRUITING","2026-03-28",{"date":103,"type":104},"2026-04-03","ACTUAL",{"date":106,"type":87},"2026-04-15",{"date":108,"type":87},"2029-04",{"name":5,"class":6},2]