[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100480004":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":29,"centralContacts":33,"locations":43,"responsibleParty":328,"collaborators":24,"id":330,"slug":331,"hasResults":332,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":336,"eligibilityCriteria":337,"healthyVolunteers":332,"sex":338,"minAge":339,"maxAge":340,"enrollmentInfo":341,"targetDuration":24,"studyType":344,"phases":345,"briefSummary":347,"conditions":348,"keywords":352,"overallStatus":46,"whyStopped":24,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":363,"locationsCount":364},{"fullName":5,"class":6},"University of Colorado, Denver","OTHER",[8,14],{"label":9,"type":6,"description":10,"interventionNames":11},"Seattle protocol, then WATS3D brushings.","Participants in the screening or surveillance population that receive the Seattle protocol, then WATS3D brushings, during the same procedure.",[12,13],"Diagnostic Test: Seattle protocol","Diagnostic Test: WATS3D brushings",{"label":15,"type":6,"description":16,"interventionNames":17},"WATS3D brushings, then Seattle Protocol.","Participants in the screening or surveillance population that receive the WATS3D brushings, then the Seattle protocol, during the same procedure.",[12,13],[19,25],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","Seattle protocol","Participants undergo 4-quadrant biopsies with standard biopsy forceps taken at 2 cm intervals. For participants undergoing a confirmatory endoscopy for cases in which discordant results are noted (WATS3D positive for dysplasia\u002Fcancer and Seattle biopsy negative for dysplasia\u002Fcancer), repeat biopsies will be taken at 1 cm intervals along with target biopsies from any visible lesions.",[9,15],null,{"type":20,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"WATS3D brushings","Participants undergo 2 WATS3D biopsies of every 5 cm segment of Barrett's esophagus, starting from the gastroesophageal junction and moving proximally through the entire segment of Barrett's.",[9,15],[30],{"name":31,"affiliation":5,"role":32},"Sachin Wani, MD","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":24,"email":38},"Alexa R DeBord, MS","CONTACT","303-724-0432","alexa.debord@cuanschutz.edu",{"name":40,"role":36,"phone":41,"phoneExt":24,"email":42},"Sandra Boimbo, MPH","303-724-8892","sandra.boimbo@cuanschutz.edu",[44,66,88,106,127,154,175,195,219,236,254,269,292,309],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Arizona Centers of Digestive Health","RECRUITING","Gilbert","Arizona","85295","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-111.78903,33.35283,{"lat":56,"lon":55},[59,62,63],{"name":60,"role":36,"phone":24,"phoneExt":24,"email":61},"Mankanwal Sachdev, MD","msachdev@azcdh.com",{"name":60,"role":32,"phone":24,"phoneExt":24,"email":24},{"name":64,"role":65,"phone":24,"phoneExt":24,"email":24},"Virender Sharma, MD","SUB_INVESTIGATOR",{"facility":67,"status":46,"city":68,"state":69,"zip":70,"country":50,"countryCode":51,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"UCLA \u002F Jonsson Comprehensive Cancer Center","Los Angeles","California","90024",{"type":53,"coordinates":72},[73,74],-118.24368,34.05223,{"lat":74,"lon":73},[77,80,82,84,86],{"name":78,"role":36,"phone":24,"phoneExt":24,"email":79},"Raman Muthusamy, MD","raman@mednet.ucla.edu",{"name":24,"role":36,"phone":81,"phoneExt":24,"email":24},"310-825-1892",{"name":83,"role":32,"phone":24,"phoneExt":24,"email":24},"Venkataraman Muthusamy, MD",{"name":85,"role":65,"phone":24,"phoneExt":24,"email":24},"Adarsh M Thaker, MD",{"name":87,"role":65,"phone":24,"phoneExt":24,"email":24},"Kevin A Ghassemi, MD",{"facility":89,"status":46,"city":90,"state":69,"zip":91,"country":50,"countryCode":51,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Kaiser Permanente","Oakland","94611",{"type":53,"coordinates":93},[94,95],-122.2708,37.80437,{"lat":95,"lon":94},[98,101,102,104],{"name":99,"role":36,"phone":24,"phoneExt":24,"email":100},"Howard Chang, MD","howard.y.chang@kp.org",{"name":99,"role":32,"phone":24,"phoneExt":24,"email":24},{"name":103,"role":65,"phone":24,"phoneExt":24,"email":24},"Gene Ma, MD",{"name":105,"role":65,"phone":24,"phoneExt":24,"email":24},"Mitchell Liverant, MD",{"facility":107,"status":46,"city":108,"state":109,"zip":110,"country":50,"countryCode":51,"cosmosGeoPoint":111,"geoPoint":115,"contacts":116},"University of Colorado Anschutz Medical Campus","Aurora","Colorado","80045",{"type":53,"coordinates":112},[113,114],-104.83192,39.72943,{"lat":114,"lon":113},[117,119,120,121,123,125],{"name":118,"role":36,"phone":37,"phoneExt":24,"email":38},"Alexa DeBord, MS",{"name":40,"role":36,"phone":41,"phoneExt":24,"email":42},{"name":31,"role":32,"phone":24,"phoneExt":24,"email":24},{"name":122,"role":65,"phone":24,"phoneExt":24,"email":24},"Steven Edmundowicz, MD",{"name":124,"role":65,"phone":24,"phoneExt":24,"email":24},"Mihir Wagh, MD",{"name":126,"role":65,"phone":24,"phoneExt":24,"email":24},"Paul Menard-Katcher, MD",{"facility":128,"status":46,"city":129,"state":130,"zip":131,"country":50,"countryCode":51,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"Connecticut Clinical Research Institute","Bristol","Connecticut","06010",{"type":53,"coordinates":133},[134,135],-72.94927,41.67176,{"lat":135,"lon":134},[138,141,142,144,146,148,150,152],{"name":139,"role":36,"phone":24,"phoneExt":24,"email":140},"Salam Zakko, MD","szakko@connecticutgi.org",{"name":139,"role":32,"phone":24,"phoneExt":24,"email":24},{"name":143,"role":65,"phone":24,"phoneExt":24,"email":24},"Peter Bloom, MD",{"name":145,"role":65,"phone":24,"phoneExt":24,"email":24},"Liam Zakko, MD",{"name":147,"role":65,"phone":24,"phoneExt":24,"email":24},"Daniel Smiley, MD",{"name":149,"role":65,"phone":24,"phoneExt":24,"email":24},"Mark Versland, MD",{"name":151,"role":65,"phone":24,"phoneExt":24,"email":24},"Eddy Castillo, MD",{"name":153,"role":65,"phone":24,"phoneExt":24,"email":24},"David Chaletsky, MD",{"facility":155,"status":46,"city":156,"state":157,"zip":158,"country":50,"countryCode":51,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"Suncoast Endoscopy of Sarasota","Sarasota","Florida","34239",{"type":53,"coordinates":160},[161,162],-82.53065,27.33643,{"lat":162,"lon":161},[165,169,174],{"name":166,"role":36,"phone":167,"phoneExt":24,"email":168},"Scott Corbett, MD","941-320-7327","scott.corbett@FDHS.com",{"name":170,"role":36,"phone":171,"phoneExt":172,"email":173},"Lisa Underwood","941-952-1145","203","lunderwood@suncoastendoscopy.com",{"name":166,"role":32,"phone":24,"phoneExt":24,"email":24},{"facility":176,"status":46,"city":177,"state":178,"zip":179,"country":50,"countryCode":51,"cosmosGeoPoint":180,"geoPoint":184,"contacts":185},"Northwestern University","Chicago","Illinois","60611",{"type":53,"coordinates":181},[182,183],-87.65005,41.85003,{"lat":183,"lon":182},[186,190,194],{"name":187,"role":36,"phone":188,"phoneExt":24,"email":189},"Srinadh Komanduri, MD","312-933-4873","sri-komanduri@northwestern.edu",{"name":191,"role":36,"phone":192,"phoneExt":24,"email":193},"Justeena Jojo","312-926-4977","justeena.jojo@northwestern.edu",{"name":187,"role":32,"phone":24,"phoneExt":24,"email":24},{"facility":196,"status":46,"city":197,"state":198,"zip":199,"country":50,"countryCode":51,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"Mayo Clinic","Rochester","Minnesota","55905",{"type":53,"coordinates":201},[202,203],-92.4699,44.02163,{"lat":203,"lon":202},[206,210,214,215,217],{"name":207,"role":36,"phone":208,"phoneExt":24,"email":209},"Prasad Iyer, MD","507-266-4338","iyer.prasad@mayo.edu",{"name":211,"role":36,"phone":212,"phoneExt":24,"email":213},"Melissa Passe","(507) 255-8693","passe.melissa@mayo.edu",{"name":207,"role":32,"phone":24,"phoneExt":24,"email":24},{"name":216,"role":65,"phone":24,"phoneExt":24,"email":24},"Cadman Leggett, MD",{"name":218,"role":65,"phone":24,"phoneExt":24,"email":24},"Chamil Codipilly, MD",{"facility":220,"status":46,"city":221,"state":222,"zip":223,"country":50,"countryCode":51,"cosmosGeoPoint":224,"geoPoint":228,"contacts":229},"Long Island Jewish Medical Center","New Hyde Park","New York","11040",{"type":53,"coordinates":225},[226,227],-73.68791,40.7351,{"lat":227,"lon":226},[230,234],{"name":231,"role":36,"phone":232,"phoneExt":24,"email":233},"Molly Stewart, BS","718-470-4667","Mstewart8@northwell.edu",{"name":235,"role":32,"phone":24,"phoneExt":24,"email":24},"Arvind Trindade, MD",{"facility":237,"status":46,"city":222,"state":222,"zip":238,"country":50,"countryCode":51,"cosmosGeoPoint":239,"geoPoint":243,"contacts":244},"Weill Cornell Medicine","10065",{"type":53,"coordinates":240},[241,242],-74.00597,40.71427,{"lat":242,"lon":241},[245,248,250,252],{"name":246,"role":36,"phone":24,"phoneExt":24,"email":247},"Felice Schnoll-Sussman, MD","fhs2001@med.cornell.edu",{"name":249,"role":32,"phone":24,"phoneExt":24,"email":24},"Felice H Schnoll-Sussman, MD",{"name":251,"role":65,"phone":24,"phoneExt":24,"email":24},"Philip O Katz, MD",{"name":253,"role":65,"phone":24,"phoneExt":24,"email":24},"Amir Soumekh, MD",{"facility":255,"status":46,"city":197,"state":222,"zip":256,"country":50,"countryCode":51,"cosmosGeoPoint":257,"geoPoint":261,"contacts":262},"University of Rochester","14642",{"type":53,"coordinates":258},[259,260],-77.61556,43.15478,{"lat":260,"lon":259},[263,266,267],{"name":264,"role":36,"phone":24,"phoneExt":24,"email":265},"Vivek Kaul, MD","vivek_kaul@urmc.rochester.edu",{"name":264,"role":32,"phone":24,"phoneExt":24,"email":24},{"name":268,"role":65,"phone":24,"phoneExt":24,"email":24},"Shivangi Kothari, MD",{"facility":270,"status":46,"city":271,"state":272,"zip":273,"country":50,"countryCode":51,"cosmosGeoPoint":274,"geoPoint":278,"contacts":279},"University of North Carolina at Chapel Hill","Chapel Hill","North Carolina","27599",{"type":53,"coordinates":275},[276,277],-79.05584,35.9132,{"lat":277,"lon":276},[280,283,286,288,290],{"name":281,"role":36,"phone":24,"phoneExt":24,"email":282},"Nicholas Shaheen, MD","nicholas_shaheen@med.unc.edu",{"name":284,"role":36,"phone":285,"phoneExt":24,"email":24},"Katie Danis","(919) 843-5884",{"name":287,"role":32,"phone":24,"phoneExt":24,"email":24},"Nicholas J Shaheen, MD",{"name":289,"role":65,"phone":24,"phoneExt":24,"email":24},"Swathi Eluri, MD",{"name":291,"role":65,"phone":24,"phoneExt":24,"email":24},"Cary C Cotton, MD",{"facility":293,"status":46,"city":294,"state":295,"zip":296,"country":50,"countryCode":51,"cosmosGeoPoint":297,"geoPoint":301,"contacts":302},"Geisinger Medical Center","Danville","Pennsylvania","17822",{"type":53,"coordinates":298},[299,300],-76.61273,40.96342,{"lat":300,"lon":299},[303,306,307],{"name":304,"role":36,"phone":24,"phoneExt":24,"email":305},"Harshit Khara, MD","hskhara@geisinger.edu",{"name":304,"role":32,"phone":24,"phoneExt":24,"email":24},{"name":308,"role":65,"phone":24,"phoneExt":24,"email":24},"Joshua Obuch, MD",{"facility":310,"status":46,"city":311,"state":312,"zip":313,"country":50,"countryCode":51,"cosmosGeoPoint":314,"geoPoint":318,"contacts":319},"Gastrointestinal Associates, PC","Knoxville","Tennessee","37909",{"type":53,"coordinates":315},[316,317],-83.92074,35.96064,{"lat":317,"lon":316},[320,324,326],{"name":321,"role":36,"phone":322,"phoneExt":24,"email":323},"Kathy Karnes, BSN, RN","865-558-0687","kkarnes@gihealthcare.com",{"name":325,"role":32,"phone":24,"phoneExt":24,"email":24},"John M Haydek, MD",{"name":327,"role":65,"phone":24,"phoneExt":24,"email":24},"Raj I Narayani, MD",{"type":329,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100480004","seattle-biopsy-protocol-versus-wide-area-transepithelial-sampling-in-patients-with-barretts-esophagus-undergoing-surveillance-100480004",false,"NCT05530343","Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance","A Multicenter Randomized Trial of Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance (The SWAT-BE Study)","SWAT-BE","Inclusion Criteria:\n\nSurveillance Population\n\n* Undergoing surveillance endoscopy for a diagnosis of non-dysplastic Barrett's esophagus (NDBE, based on last endoscopic procedure; patients with prior history of low-grade dysplasia\u002Findefinite for dysplasia with NDBE at last endoscopy can be included)\n* Barrett's esophagus (BE) length of at least M1\n* English and Spanish speaking\n* Able to comprehend and complete the consent form\n* Age18-89 years\n* Life-expectancy of at least 2 years\n\nScreening Population\n\n* Undergoing endoscopy for screening of BE\n* BE length of at least M1\n* English and Spanish speaking\n* Able to comprehend and complete the consent form\n* Age 18-89 years\n* Expected life-expectancy of at least 2 years\n\nPhysicians\n\n-All participating sites will include physicians who are trained in the use of WATS3D and certified by the site PI. All endoscopists will need to complete a minimum of three cases to be eligible to participate in the study.\n\nExclusion Criteria:\n\nSurveillance Population\n\n* BE patients undergoing surveillance or evaluation for endoscopic eradication therapy (EET) for prior diagnosis of BE related dysplasia or esophageal adenocarcinoma (EAC)\n* Active erosive esophagitis with LA Grade B or higher\n* Esophageal varices\n* Prior history of EET\n* Prior history of esophageal or gastric surgery, except for uncomplicated fundoplication\n* Pregnancy\n\nScreening Population\n\n* BE patients undergoing surveillance or evaluation for EET for prior diagnosis for BE-related dysplasia or EAC\n* Active erosive esophagitis with LA Grade B or higher\n* Esophageal varices\n* Prior history of esophageal or gastric surgery, except for uncomplicated fundoplication\n* Pregnancy","ALL","18 Years","89 Years",{"count":342,"type":343},2298,"ESTIMATED","INTERVENTIONAL",[346],"NA","The purpose of this research study is to learn about the best approach to sample patients with known or suspected Barrett's esophagus (BE) by comparing the standard Seattle biopsy protocol to sampling using wide area transepithelial sampling (WATS3D).\n\nBarrett's esophagus is a common condition that is used to spot patients at increased risk of developing a type of cancer in the esophagus (swallowing tube) called esophageal adenocarcinoma. The 5-year survival rate is as low as 18% for patients who get esophageal adenocarcinoma, but the rate may be improved if the cancer is caught in its early stages. Barrett's esophagus can lead to dysplasia, or precancerous changes, which occurs when cells look abnormal but have not developed into cancer. If the abnormal cells increase from being slightly abnormal (low-grade dysplasia), to being very abnormal (high-grade dysplasia), the risk of developing cancer (esophageal adenocarcinoma) goes up. Therefore, catching dysplasia early is very important to prevent cancer.\n\nEndoscopic surveillance is a type of procedure where endoscopists run a tube with a light and a camera on the end of it down a patients throat and remove a small piece of tissue. The piece of tissue, called a biopsy, is about the size of the tip of a ball-point pen and is checked for abnormal cells and cancer cells.\n\nPatients are being asked to be in this research study because they have been diagnosed with BE or suspected to have BE, and will need an esophagogastroduodenoscopy (EGD).\n\nPatients with BE undergo sampling using the Seattle biopsy protocol during which samples are obtained from the BE in a four quadrant fashion every 2 cm along with target biopsies from any abnormal areas within the BE. Another sampling approach is WATS3D which utilizes brushings from the BE.\n\nWhile both of these procedures are widely accepted approaches to sampling patients with BE during endoscopy, there is not enough research to show if one is better than the other.\n\nParticipants in this study will undergo sampling of the BE using both approaches (Seattle biopsy protocol and WATS-3D); the order of the techniques will be randomized.\n\nUp to 2700 participants will take part in this research. This is a multicenter study involving several academic, community and private hospitals around the country.",[349,350,351],"Barrett Esophagus","Barretts Esophagus With Dysplasia","Esophageal Adenocarcinoma",[353,351,354],"Barrett's Esophagus","Dysplasia","2026-06-29",{"date":357,"type":358},"2026-07-01","ACTUAL",{"date":360,"type":358},"2022-10-03",{"date":362,"type":343},"2026-06",{"name":5,"class":6},14]