[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603062":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":26,"locations":35,"responsibleParty":103,"collaborators":10,"id":105,"slug":106,"hasResults":107,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":107,"sex":112,"minAge":113,"maxAge":10,"enrollmentInfo":114,"targetDuration":10,"studyType":117,"phases":10,"briefSummary":118,"conditions":119,"keywords":122,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":135},{"fullName":5,"class":6},"Minneapolis Heart Institute Foundation","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"1 group undergoing guideline directed TEER with FDA approved MitraClip",null,"Cohort will undergo a clinically indicated baseline CMR study with contrast up to 90 days before TEER procedure. Quality of life questionnaire will also be completed. At 6 months, individuals will return to the clinic to repeat quality of life questionnaires, the CMR study and a transthoracic echocardiogram.",[13],"Diagnostic Test: Cardiac MRI",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIAGNOSTIC_TEST","Cardiac MRI","Clinically indicated baseline CMR study with contrast up to 90 days before TEER procedure, including KCCQ questionnaire. At 6 months, participants will return for repeat of KCCQ, CMR study and a transthoracic echocardiogram. Blood samples, done as standard clinical care for hemotocrit for ECV calculation, will be obtained.",[9],[21],"Transthoracic echocardiogram",[23],{"name":24,"affiliation":5,"role":25},"João Cavalcante, MD","PRINCIPAL_INVESTIGATOR",[27,31],{"name":24,"role":28,"phone":29,"phoneExt":10,"email":30},"CONTACT","612-863-3900","joao.cavalcante@allina.com",{"name":32,"role":28,"phone":33,"phoneExt":10,"email":34},"Sarah Schwager, RN","612-863-6257","sarah.schwager@allina.com",[36,52,63,73,82,92],{"facility":5,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Minneapolis","Minnesota","55407","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-93.26384,44.97997,{"lat":47,"lon":46},[50,51],{"name":32,"role":28,"phone":10,"phoneExt":33,"email":34},{"name":24,"role":25,"phone":10,"phoneExt":10,"email":10},{"facility":53,"status":54,"city":55,"state":56,"zip":57,"country":41,"countryCode":42,"cosmosGeoPoint":58,"geoPoint":62,"contacts":10},"Sanger Heart and Vascular Institute","ENROLLING_BY_INVITATION","Charlotte","North Carolina","28204",{"type":44,"coordinates":59},[60,61],-80.84313,35.22709,{"lat":61,"lon":60},{"facility":64,"status":54,"city":65,"state":66,"zip":67,"country":41,"countryCode":42,"cosmosGeoPoint":68,"geoPoint":72,"contacts":10},"The Christ Hospital Health Network","Cincinnati","Ohio","45219",{"type":44,"coordinates":69},[70,71],-84.51439,39.12711,{"lat":71,"lon":70},{"facility":74,"status":54,"city":75,"state":66,"zip":76,"country":41,"countryCode":42,"cosmosGeoPoint":77,"geoPoint":81,"contacts":10},"Cleveland Clinic","Cleveland","44195",{"type":44,"coordinates":78},[79,80],-81.69541,41.4995,{"lat":80,"lon":79},{"facility":83,"status":54,"city":84,"state":85,"zip":86,"country":41,"countryCode":42,"cosmosGeoPoint":87,"geoPoint":91,"contacts":10},"Inova Fairfax Medical Campus","Falls Church","Virginia","22042",{"type":44,"coordinates":88},[89,90],-77.17109,38.88233,{"lat":90,"lon":89},{"facility":93,"status":54,"city":94,"state":10,"zip":95,"country":96,"countryCode":97,"cosmosGeoPoint":98,"geoPoint":102,"contacts":10},"IRCCS Ospedale San Raffaele","Milan","20132","Italy","IT",{"type":44,"coordinates":99},[100,101],9.18951,45.46427,{"lat":101,"lon":100},{"type":104,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100603062","secondary-mitral-regurgitation-treatment-with-mitraclip-and-assessment-by-cardiac-magnetic-resonance-100603062",false,"NCT07131631","Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance","SMARTER-CMR","Inclusion Criteria:\n\n1\\. Adult patients (≥ 18 years old) with heart failure and reduced ejection fraction (LVEF \\\u003C 50% defined by echocardiography), medically and device-optimized according to guidelines, with significant FMR undergoing TEER with FDA-approved MitraClip device (Abbott Structural, USA)\n\nExclusion Criteria:\n\n1. Concomitant PCI and TEER\n2. Congenital heart disease\n3. Stage D heart failure\n4. Uncontrolled atrial fibrillation\n5. Pregnancy\n6. \\> moderate tricuspid regurgitation\n7. \\>moderate aortic regurgitation or stenosis\n8. Contraindications or unable to undergo CMR\n9. Prior mitral valve repair or replacement","ALL","18 Years",{"count":115,"type":116},125,"ESTIMATED","OBSERVATIONAL","This is a multi-center, prospective, observational study designed to evaluate the impact of LV myocardial fibrosis extent assessed by CMR on LV reverse remodeling and clinical outcomes post TEER. The target sample will be up to 125 patients enrolled to achieve 100 evaluable at 6 months of follow-up. Enrollment will occur at up to eight centers.",[120,121],"Heart Failure and Reduced Ejection Fraction","Functional Mitral Regurgitation",[123,124,125],"heart failure","reduced ejection fraction","functional mitral regurgitation","2025-12-16",{"date":128,"type":129},"2025-12-23","ACTUAL",{"date":131,"type":129},"2022-03-03",{"date":133,"type":116},"2027-07",{"name":5,"class":6},6]