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Patients then undergo SOC colposcopy with or without cervical biopsy\u002Fendocervical curettage and\u002For cervical excisional procedures as clinically indicated.",[13,14,15,16,17,18,19,20,21],"Procedure: Biospecimen Collection","Procedure: Cervical Biopsy","Procedure: Colposcopy","Other: Electronic Health Record Review","Procedure: Endocervical Curettage","Procedure: Excision","Procedure: HPV Self-Collection","Procedure: Human Papillomavirus Test","Other: Questionnaire Administration",[23,33,38,44,49,53,61,69,77],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"PROCEDURE","Biospecimen Collection","Undergo collection of a cervical sample by clinician",[9],[29,30,31,32],"Biological Sample Collection","Biospecimen Collected","Sample Collection","Specimen Collection",{"type":24,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"Cervical Biopsy","Undergo cervical biopsy",[9],null,{"type":24,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Colposcopy","Undergo colposcopy",[9],[43],"CP",{"type":45,"name":46,"description":47,"armGroupLabels":48,"otherNames":37},"OTHER","Electronic Health Record Review","Ancillary studies",[9],{"type":24,"name":50,"description":51,"armGroupLabels":52,"otherNames":37},"Endocervical Curettage","Undergo endocervical curettage",[9],{"type":24,"name":54,"description":55,"armGroupLabels":56,"otherNames":57},"Excision","Undergo cervical excisional procedure",[9],[58,59,60],"Abscission","Extirpation","Surgical Removal",{"type":24,"name":62,"description":63,"armGroupLabels":64,"otherNames":65},"HPV Self-Collection","Undertake self-collection of vaginal sample",[9],[66,67,68],"At-home HPV Self Collection","HPV Self Collection","Human Papillomavirus Self-Collection",{"type":24,"name":70,"description":71,"armGroupLabels":72,"otherNames":73},"Human Papillomavirus Test","Undergo HPV testing of self-collected vaginal samples and cervical samples",[9],[74,75,76],"HPV Assay","HPV Test","Human Papillomavirus",{"type":45,"name":78,"description":47,"armGroupLabels":79,"otherNames":37},"Questionnaire Administration",[9],[81],{"name":82,"affiliation":83,"role":84},"Vikrant V Sahasrabuddhe","National Cancer Institute Division of Cancer Prevention","PRINCIPAL_INVESTIGATOR",[86,106,121,136,148,163,178,193,201,216,231,246,256,271,285,294,309,324],{"facility":87,"status":88,"city":89,"state":90,"zip":91,"country":92,"countryCode":93,"cosmosGeoPoint":94,"geoPoint":99,"contacts":100},"University of Alabama at Birmingham Cancer Center","RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":95,"coordinates":96},"Point",[97,98],-86.80249,33.52066,{"lat":98,"lon":97},[101,105],{"name":102,"role":103,"phone":37,"phoneExt":37,"email":104},"Warner K. 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Chiao","eychiao@mdanderson.org",{"name":306,"role":84,"phone":37,"phoneExt":37,"email":37},{"facility":310,"status":88,"city":311,"state":312,"zip":313,"country":92,"countryCode":93,"cosmosGeoPoint":314,"geoPoint":318,"contacts":319},"Huntsman Cancer Institute\u002FUniversity of Utah","Salt Lake City","Utah","84112",{"type":95,"coordinates":315},[316,317],-111.89105,40.76078,{"lat":317,"lon":316},[320,323],{"name":321,"role":103,"phone":37,"phoneExt":37,"email":322},"Deanna L. Kepka","deanna.kepka@hci.utah.edu",{"name":321,"role":84,"phone":37,"phoneExt":37,"email":37},{"facility":325,"status":88,"city":326,"state":327,"zip":328,"country":92,"countryCode":93,"cosmosGeoPoint":329,"geoPoint":333,"contacts":334},"West Virginia University Healthcare","Morgantown","West Virginia","26506",{"type":95,"coordinates":330},[331,332],-79.9559,39.62953,{"lat":332,"lon":331},[335,338],{"name":336,"role":103,"phone":37,"phoneExt":37,"email":337},"Krista S. Pfaendler","krista.pfaendler@hsc.wvu.edu",{"name":336,"role":84,"phone":37,"phoneExt":37,"email":37},{"type":340,"investigatorFullName":37,"investigatorTitle":37,"investigatorAffiliation":37,"oldNameTitle":37,"oldOrganization":37},"SPONSOR","100614579","self-collection-for-hpv-testing-to-improve-cervical-cancer-prevention-ship-trial-lmi-001-a-s04-100614579",false,"NCT07281430","Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial (LMI-001-A-S04)","NCI Cervical Cancer 'Last Mile' Initiative 'Self-Collection for HPV Testing to Improve Cervical Cancer Prevention' (SHIP) Trial LMI-001-A-S04","Inclusion Criteria:\n\n* Willingness and ability to provide a documented informed consent\n* Is 25 years or older\n* Has an intact cervix\n* Has had a referral for colposcopy in which routine cervical cancer screening has included positive HPV testing (HPV primary screening, co-testing, or atypical squamous cells of undetermined significance \\[ASC-US\\] cytology triage) or abnormal cytology performed within the past 12 months preceding the referral visit, and\u002For for cervical excisional procedure\n* Willing and able to undergo colposcopy, and if clinically indicated for SOC purposes, a biopsy, endocervical curettage, and\u002For a cervical excisional procedure, as applicable\n\nExclusion Criteria:\n\n* Is pregnant when presenting for the referral visit or gave birth within the past 3 months\n* Has a known history of excisional or ablative therapy to the cervix (e.g., loop electrosurgical excision procedure \\[LEEP\\], cone biopsy, cervical laser surgery, cryotherapy, thermal ablation) in the last 12 months prior to the referral visit\n* Has had a complete or partial hysterectomy, either supracervical or involving removal of the cervix, via self-report or confirmation via medical records\n* Known medical conditions that, in the opinion of the investigator, preclude study participation\n* Previous participation in the SHIP Trial or another cervical cancer screening study within the past 12 months. Participation is defined as completing the self-collection\n* Is experiencing unusual bleeding or pelvic pain",true,"FEMALE","25 Years",{"count":352,"type":353},500,"ESTIMATED","INTERVENTIONAL",[356],"NA","This clinical trial evaluates the use of self-collected vaginal samples for human papillomavirus (HPV) testing in patients referred for a colposcopy and\u002For cervical excisional procedures to improve cervical cancer prevention. HPV is a common virus which usually causes infections that last only a few months, but sometimes can last longer. HPV is known to cause a variety of cancers including cervical cancer. Even though there are ways to detect cervical cancer, many individuals are not diagnosed. Over half of all new cervical cancer cases are among those who have either never been screened or who are not screened enough. The low screening numbers show more testing needs to be done. Without appropriate screening and care, preventable precancer may turn into cancer. A new way to detect cervical cancer is to have individuals collect their own sample for HPV testing to know their risk for cervical cancer. This may give individuals more flexibility and comfort having the ability to collect samples themselves, compared to a doctor performing a speculum examination and collecting the samples in a clinic. Information gathered from this study compares clinical accuracy of HPV testing on self-collected vaginal samples versus cervical samples collected by clinician.\n\nThe Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial is part of the National Cancer Institute (NCI)'s Cervical Cancer 'Last Mile' Initiative, a public private partnership that seeks to increase access to cervical cancer screening. The SHIP Trial focuses on developing clinical evidence to inform the US Food and Drug Administration (FDA)'s regulatory reviews of self-collection approaches as alternative sample collection approaches for cervical cancer screening. Several industry partner-specific self-collection device and assay combinations will be non-competitively and independently evaluated with a similar study design framework to inform pre-approval and\u002For post-approval regulatory requirements.",[359,360],"Cervical Carcinoma","Human Papillomavirus Infection","2026-06-16",{"date":363,"type":364},"2026-06-17","ACTUAL",{"date":366,"type":364},"2025-11-24",{"date":368,"type":353},"2026-12-31",{"name":5,"class":6},18]