[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608671":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":33,"centralContacts":38,"locations":44,"responsibleParty":61,"collaborators":63,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":33,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":93,"whyStopped":33,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Chang Gung Memorial Hospital","OTHER",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"A1 Autologous Semitendinosus Tendon Graft (Randomized)","EXPERIMENTAL","Patients randomized to this arm will undergo meniscal reconstruction using autologous semitendinosus tendon grafts (diameter ≥ 6 mm). Standard two-tunnel fixation technique will be applied, with Fibertape internal brace augmentation. ACL reconstruction may be performed simultaneously if indicated.",[13],"Procedure: Autologous Semitendinosus Tendon Graft",{"label":15,"type":10,"description":16,"interventionNames":17},"A2 Meniscal Allograft Transplantation (Randomized)","Patients randomized to this arm will receive size-matched fresh-frozen meniscal allografts. Fixation will be performed using the standard two-tunnel technique.",[18],"Procedure: Meniscal Allograft Transplantation (MAT)",{"label":20,"type":10,"description":21,"interventionNames":22},"Meniscal Allograft Transplantation (Patient Preference)","Patients who decline randomization but choose allograft transplantation will undergo the same surgical procedure as Arm A2, with fresh-frozen meniscal allografts.",[18],{"label":24,"type":10,"description":25,"interventionNames":26},"Autologous Semitendinosus Tendon Graft (Patient Preference)","Patients who decline randomization but choose autologous tendon grafting will undergo the same procedure as Arm A1, using semitendinosus tendon grafts with Fibertape internal brace augmentation.",[13],[28,34],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"PROCEDURE","Autologous Semitendinosus Tendon Graft","Meniscal reconstruction will be performed using autologous semitendinosus tendon harvested from the ipsilateral leg. The graft diameter must be at least 6 mm. A two-tunnel fixation technique will be employed, securing the graft to the tibial plateau at the anatomic meniscal root sites. The graft will be shaped and positioned to mimic the native meniscal contour. Fibertape internal brace augmentation will be added to enhance fixation strength and graft stability. If concomitant anterior cruciate ligament reconstruction is indicated, the graft choice and ACL technique will be determined by the surgeon, without restriction. Postoperative rehabilitation will follow a standardized protocol across all centers.",[9,24],null,{"type":29,"name":35,"description":36,"armGroupLabels":37,"otherNames":33},"Meniscal Allograft Transplantation (MAT)","Meniscal allograft transplantation will use size-matched, fresh-frozen allograft menisci prepared according to institutional tissue bank standards. Grafts will be fixed using a two-tunnel bone plug technique, restoring the anatomic root insertions. The allograft will be centrally positioned within the tibiofemoral compartment, and centralization sutures may be added at the discretion of the operating surgeon. All procedures will be standardized across participating centers, and postoperative rehabilitation protocols will be identical to those used in the autologous graft arm.",[15,20],[39],{"name":40,"role":41,"phone":42,"phoneExt":33,"email":43},"Cheng-Pang Yang","CONTACT","+886919087214","ronnie80097@gmail.com",[45],{"facility":46,"status":33,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Chang Gung memorial hospital, Taoyuan, taoyuan 333","Taoyuan City","Taoyuan","33305","Taiwan","TW",{"type":53,"coordinates":54},"Point",[55,56],121.29696,24.99368,{"lat":56,"lon":55},[59],{"name":40,"role":41,"phone":60,"phoneExt":33,"email":43},"+886 0919087214",{"type":62,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR",[64],{"name":65,"class":6},"Karolinska University Hospital","100608671","semitendinosus-autograft-vs-meniscal-allograft-in-post-meniscectomy-syndrome-100608671",false,"NCT07204587","Semitendinosus Autograft vs Meniscal Allograft in Post-Meniscectomy Syndrome","A Stratified, Partially Randomized Study Comparing Autologous Semitendinosus Tendon Graft and Meniscal Allograft Transplantation in Young Adults With Post-Meniscectomy Syndrome","MAT","Inclusion Criteria:\n\n* Adults aged 18 to 45 years\n\nHistory of partial meniscectomy \\> 6 months prior to enrollment\n\nSymptomatic post-meniscectomy syndrome (knee pain, swelling, or functional decline)\n\nMRI showing cartilage status ≤ Outerbridge grade 2\n\nKnee joint stability (or stabilized during the index surgery)\n\nBody mass index (BMI) \\\u003C 30\n\nWillingness to provide written informed consent\n\nExclusion Criteria:\n\nTibial slope \\> 16°\n\nRadiographic or arthroscopic evidence of advanced cartilage degeneration (Outerbridge \\> 2 or ICRS ≥ 3)\n\nPresence of inflammatory arthritis or systemic inflammatory joint disease\n\nHistory of cartilage repair surgery\n\nMalalignment \\> 5° not corrected\n\nUntreated ligamentous instability\n\nAny other condition judged by the investigator to compromise study participation or outcomes","ALL","18 Years","45 Years",{"count":78,"type":79},40,"ESTIMATED","INTERVENTIONAL",[82],"NA","This multicenter, stratified, partially randomized clinical trial aims to compare autologous semitendinosus tendon graft and meniscal allograft transplantation (MAT) in young adults with post-meniscectomy syndrome. The meniscus plays a critical role in load distribution, shock absorption, and joint stability. After meniscectomy, insufficient meniscal tissue often leads to persistent pain, swelling, and functional decline, increasing the risk of early osteoarthritis.\n\nTwo reconstructive strategies are clinically available: MAT provides immediate biomechanical function but requires donor matching and carries higher costs, while autologous tendon graft offers stable supply and no immunologic risk but lacks long-term clinical validation.\n\nIn this study, 40 patients aged 18-45 years will be enrolled. Participants will be allocated into four groups (randomized MAT, randomized autograft, patient-preference MAT, patient-preference autograft). All procedures will use a two-tunnel fixation technique with additional internal brace support.\n\nThe primary endpoint is the improvement in KOOS (Knee Injury and Osteoarthritis Outcome Score) at 24 months postoperatively. Secondary endpoints include MRI-based assessment of graft morphology and extrusion, reoperation rate, complications, patient satisfaction, and return-to-sport time.\n\nThis trial will provide critical evidence regarding the comparative effectiveness and feasibility of tendon autograft versus meniscal allograft in real-world clinical settings, potentially informing surgical decision-making and future treatment guidelines for post-meniscectomy syndrome.",[85,86,87],"Meniscal Injuries","Meniscal Tear","Meniscus Lesion",[89,90,91,92],"meniscal allograft","autologous tendon graft","Post-meniscectomy syndrome","Meniscus deficiency","NOT_YET_RECRUITING","2025-09-24",{"date":96,"type":97},"2025-10-02","ACTUAL",{"date":99,"type":79},"2025-10-01",{"date":101,"type":79},"2029-09-30",{"name":5,"class":6},1]