[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550686":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":10,"centralContacts":10,"locations":28,"responsibleParty":54,"collaborators":10,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":10,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":10,"studyType":73,"phases":10,"briefSummary":74,"conditions":75,"keywords":10,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Trio Fertility","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Thin endometrial lining",null,"Patients following long-term use of oral contraceptives with known thin endometrial lining (less than 7mm, confirmed in at least two cycles and unresponsive to estrogen-induced growth).\n\nWe will ask each woman to undergo an endometrial biopsy as part of the study during their luteal phase.",[13],"Procedure: Endometrial Biopsy",{"label":15,"type":10,"description":16,"interventionNames":17},"Asherman's syndrome","Patients with Asherman's syndrome following Dilation and curettage (D\\&C). We will ask each woman to undergo an endometrial biopsy as part of the study during their luteal phase.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Control","Patients already scheduled to undergo an endometrial biopsy for infertility management.\n\nWe will ask each woman to undergo an endometrial biopsy as part of the study during their luteal phase. In some cases, we may be able to access archived endometrial samples from women in the control group who agree to participate and who have already had an endometrial biopsy.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"PROCEDURE","Endometrial Biopsy","An endometrial biopsy is the removal of a small piece of tissue from the endometrium, which is the lining of the uterus. Endometrial biopsies are commonly done to check for the window of implantation, to determine ovulation or for enhancing implantation (procedure called endometrial scratching). For this purpose, we will use a \"Pipelle\" catheter. This procedure is very common in gynecologic practice and\n\ngenerally considered safe. In most of the cases this procedure is indicated for evaluation of irregular vaginal bleeding, vaginal bleeding in post-menopausal women and for infertility related problems (recurrent implantation failures for example).",[15,19,9],[29],{"facility":5,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Toronto","Ontario","M5G 2K4","Canada","CA",{"type":37,"coordinates":38},"Point",[39,40],-79.39864,43.70643,{"lat":40,"lon":39},[43,49,53],{"name":44,"role":45,"phone":46,"phoneExt":47,"email":48},"Robert. F. Casper, Dr.","CONTACT","416-506-0804","3228","casper@lunenfeld.ca",{"name":50,"role":45,"phone":46,"phoneExt":51,"email":52},"Yasaman Sadeghi, M.Sc.","2268","yasamans@triofertility.com",{"name":44,"role":45,"phone":10,"phoneExt":10,"email":10},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":58,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dr. Robert F. Casper","Scientific Director, MD, FRCSC, REI","University of Toronto","100550686","senescent-endometrial-cells-in-patients-with-thin-endometrial-lining-100550686",false,"NCT06450301","Senescent Endometrial Cells in Patients with Thin Endometrial Lining","Is Thin Endometrial Lining Associated with Senescent Endometrial Cells","Inclusion Criteria:\n\n* Age 18-39\n* BMI - up to 35\n* Thin endometrium after OCP use\n* Asherman's syndrome\n* Women already undergoing endometrial biopsy for infertility testing (eg. EMMA testing)\n* Women with archived endometrial biopsy samples\n\nExclusion Criteria:\n\n* Women with systemic disease (Rheumatic disease, DM)\n* Women with coagulopathies\n* Women with active pelvic inflammatory process\n* Uterine anomalies\n* Pregnant women\n* Any hormonal contraception use or IUD",true,"FEMALE","18 Years","39 Years",{"count":71,"type":72},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to determine if thin endometrial lining that is unresponsive to estrogen might be associated with the presence of senescent cells in patients following long-term use of oral contraceptives. The main question it aims to answer is:\n\nAre there any senescent cells present in thin endometrial lining?\n\nDuring the luteal phase of the cycle, participants will will undergo:\n\n* Gynecologic US to measure the endometrial lining thickness and pattern.\n* Endometrial biopsy with Pipelle catheter",[76,77,78],"Asherman's Syndrome","Thin Endometrial Lining","Cell Senescence","2024-11-18",{"date":81,"type":82},"2024-11-21","ACTUAL",{"date":84,"type":82},"2024-09-11",{"date":86,"type":72},"2027-06",{"name":5,"class":6},1]