[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643263":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":38,"responsibleParty":58,"collaborators":26,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":90,"whyStopped":26,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Hospices Civils de Lyon","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Food Odor Stimulation","ACTIVE_COMPARATOR","Participants are exposed to a pleasant appetitive food odor delivered through a ScentRealm collar beginning 10 minutes before ingestion of a 75 g oral glucose load and continuing according to a prerecorded sequence during the metabolic test visit.",[13,14],"Behavioral: Pleasant Food Odor Stimulation","Behavioral: Control Environmental Condition",{"label":16,"type":17,"description":18,"interventionNames":19},"Control Condition","PLACEBO_COMPARATOR","Participants undergo the same standardized metabolic test visit and OGTT procedures in the same test environment without food odor stimulation.",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Pleasant Food Odor Stimulation","Exposure to an experimentally selected appetitive food odor (madeleine odor) delivered using a programmable ScentRealm collar in a standardized test room beginning at T-10 minutes before OGTT.",[16,9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Control Environmental Condition","Standardized testing environment identical to the experimental visit but without diffusion of the appetitive food odor.",[16,9],[32],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"Anne Laure MD CASTELL, Dr","CONTACT","+33 4 78 86 19 72","+33","anne-laure.castell@chu-lyon.fr",[39],{"facility":40,"status":26,"city":41,"state":26,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Centre de Recherche en Nutrition Humaine Rhône-Alpes, Centre Hospitalier Lyon Sud","Pierre-Bénite","69495","France","FR",{"type":46,"coordinates":47},"Point",[48,49],4.82424,45.70359,{"lat":49,"lon":48},[52,54],{"name":53,"role":34,"phone":35,"phoneExt":36,"email":37},"Anne Laure CASTELL, MD",{"name":55,"role":34,"phone":56,"phoneExt":36,"email":57},"Nathalie Feugier-Favier, MD","+33 4 78 86 29 54","nathalie.feugier@chu-lyon.fr",{"type":59,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100643263","sensilins-impact-of-cephalic-phase-insulin-release-induced-by-an-environmental-food-odor-stimulus-on-glucose-homeostasis-according-to-insulin-sensitivity-level-100643263",false,"NCT07638111","SENSILINS: Impact of Cephalic Phase Insulin Release Induced by an Environmental Food Odor Stimulus on Glucose Homeostasis According to Insulin Sensitivity Level","Impact of Cephalic Phase Insulin Release Induced by an Environmental Food Odor Stimulus on Glucose Homeostasis According to Insulin Sensitivity Level","SENSILNS","Inclusion Criteria\n\n* Age 18 to 50 years inclusive\n* Stable body weight during the previous 3 months (±5% of total body weight)\n* Willing to comply with the full study protocol\n* Sedentary lifestyle or stable regular physical activity, with agreement to keep this unchanged throughout the study\n* Able to understand study information, read and write French, and provide written informed consent\n* Affiliated with a social security scheme or equivalent\n* Non-smoker and non-vaper\n* Willing not to take dietary supplements, probiotics, prebiotics, or laxatives for 10 days before each visit\n* For women of childbearing potential: negative serum pregnancy test; not pregnant and not breastfeeding\n* Mean score between 1 and 2 on the 3 specific CiTAS questionnaire statements used as inclusion criteria\n* ETOC flash olfactory screening: able to detect the odor-containing vial among 4 presented vials for all 7 odors tested\n* Able to identify the madeleine odor used in the study\n* Rated pleasantness\u002Fappetence of the madeleine odor above 1\u002F9\n* For the no-overweight group: BMI 19 to \\\u003C25 kg\u002Fm² and HOMA-IR \\\u003C1.7\n* For the obesity group: BMI 30 to \\\u003C35 kg\u002Fm² and low-to-moderate insulin resistance based on HOMA-IR \\[protocol inconsistency to resolve; see note below\\]\n\nExclusion Criteria\n\n* Unstable medical or psychological conditions that could impair compliance, safety, or study participation in the investigator's judgment\n* Alcohol consumption \\>30 g\u002Fday, or established abuse\u002Fdependence on another drug\n* Ongoing exclusion period from another study listed in the national volunteer file\n* Legal protection measure (guardianship\u002Fcuratorship)\n* Deprivation of liberty by judicial or administrative decision\n* Exceeded annual compensation limit for research participation\n* Lack of valid required health documentation in the event of exceptional governmental epidemic measures\n* Blood donation within 2 months before inclusion visit\n* Limited venous access making repeated blood sampling\u002Fcatheter placement difficult\n* Current or permanent anosmia or olfactory disorder\n* Type 1 or type 2 diabetes, treated or untreated\n* History of gestational diabetes\n* Known or treated hypertension\n* Blood pressure \\>160 \\[unit missing; likely mmHg systolic threshold\\]\n* Dyslipidemia, treated or untreated\n* Triglycerides \\>3 mmol\u002FL\n* Allergic rhinitis\n* Nasosinusal polyposis\n* History of intestinal or abdominal surgery except appendectomy or simple hernia repair\n* History of ENT or neurological surgery\n* Severe eating disorder (for example anorexia, bulimia, binge-eating disorder, night eating)\n* Any pathology detected on clinical examination or medical interview judged by the investigator to interfere with study endpoints or participant safety\n* Any biological abnormality judged by the investigator to interfere with study endpoints or participant safety\n* Use of treatments likely to interfere with study measurements, for example antidepressants, antiepileptics, neuroleptics, CPAP treatment for sleep apnea, nasal spray medications, or anti-obesity drug treatment, according to investigator judgment",true,"ALL","18 Years","50 Years",{"count":73,"type":74},20,"ESTIMATED","INTERVENTIONAL",[77],"NA","This single-center, randomized, single-blind, 2-period crossover interventional study will evaluate whether exposure to a pleasant food odor 10 minutes before a 75 g oral glucose tolerance test (OGTT) modifies glucose homeostasis in adults with different metabolic phenotypes. Participants will undergo two experimental conditions in random order: food odor stimulation and control condition without odor, separated by a 4-week washout. The main objective is to quantify the within-subject effect of food odor stimulation on the incremental area under the glucose curve (iAUC) from 0 to 120 minutes during OGTT and to assess whether this effect differs according to metabolic status. Two predefined groups will be enrolled: adults without overweight and without insulin resistance, and adults with class I obesity and low-to-moderate insulin resistance. Secondary objectives include characterization of cephalic phase insulin release (CPIR), C-peptide and GLP-1 responses, glycemic kinetics, associations between CPIR and metabolic responses, and participant acceptability of the test environment and olfactory stimulation. A plasma biobank will be constituted from part of the collected samples for future research.",[80,81],"Obesity & Overweight","Insulin Resistance Syndrome",[83,84,85,86,87,88,89],"Glucose Homeostasis","Cephalic Phase Insulin Release","Food odor","Olfaction","Oral glucose tolerance test","Insulin secretion","GLP-1","NOT_YET_RECRUITING","2026-06-04",{"date":93,"type":94},"2026-06-10","ACTUAL",{"date":96,"type":74},"2026-06",{"date":98,"type":74},"2027-07",{"name":5,"class":6},1]