[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627595":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":44,"locations":54,"responsibleParty":89,"collaborators":92,"id":96,"slug":97,"hasResults":98,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":105,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":31,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":125,"whyStopped":31,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":135},{"fullName":5,"class":6},"Stanford University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Vision-to-sound sensory substitution training","EXPERIMENTAL","Participants will learn to interpret the sound patterns that are converted from visual information while using the assistive technology.",[13],"Device: Vision-to-sound converter (AI Sight)",{"label":15,"type":10,"description":16,"interventionNames":17},"Vision-to-touch sensory substitution training","Participants will learn to interpret the touch patterns that are converted from visual information while using the assistive technology.",[18],"Device: Electrotactile display (BrainPort)",{"label":20,"type":21,"description":22,"interventionNames":23},"Sham training","SHAM_COMPARATOR","Participants will learn to interpret the sound\u002Ftouch patterns verbally without presenting the sensory signals from the assistive technologies.",[24],"Device: Sham",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","Electrotactile display (BrainPort)","The BrainPort is a non-surgical assistive device that translates digital information from a video camera to gentle electrotactile stimulation patterns on the surface of the tongue.",[15],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Vision-to-sound converter (AI Sight)","The AI Sight is an auditory technology software that can convert visual information into sound patterns, which can be delivered through regular headphones.",[9],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Sham","Participants will wear the assistive technology system, but there will be no active sensory signals applied.",[20],[41],{"name":42,"affiliation":5,"role":43},"Kevin C. Chan, PhD","PRINCIPAL_INVESTIGATOR",[45,50],{"name":46,"role":47,"phone":48,"phoneExt":31,"email":49},"Study Team","CONTACT","650-497-0625","kevinchan@stanford.edu",{"name":51,"role":47,"phone":52,"phoneExt":31,"email":53},"Mariana Nunez, CCRP","650-497-7846","mnunez1@stanford.edu",[55,73],{"facility":56,"status":31,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Byers Eye Institute at Stanford University","Palo Alto","California","94303","United States","US",{"type":63,"coordinates":64},"Point",[65,66],-122.14302,37.44188,{"lat":66,"lon":65},[69,71],{"name":46,"role":47,"phone":70,"phoneExt":31,"email":49},"(650) 497-0625",{"name":51,"role":47,"phone":72,"phoneExt":31,"email":53},"(650) 497-7846",{"facility":74,"status":31,"city":75,"state":58,"zip":76,"country":60,"countryCode":61,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"LUCAS Center for Imaging","Stanford","94305",{"type":63,"coordinates":78},[79,80],-122.16608,37.42411,{"lat":80,"lon":79},[83,86],{"name":46,"role":47,"phone":84,"phoneExt":31,"email":85},"(650) 512-7836","lucascenter@stanford.edu",{"name":87,"role":47,"phone":31,"phoneExt":31,"email":88},"Karla Epperson, RT(MR)(ARMRIT)","karlae@stanford.edu",{"type":43,"investigatorFullName":90,"investigatorTitle":91,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Kevin Chuen Wing Chan","Associate Professor of Ophthalmology",[93],{"name":94,"class":95},"National Eye Institute (NEI)","NIH","100627595","sensory-substitution-and-brain-plasticity-following-vision-loss-100627595",false,"NCT07450677","Sensory Substitution and Brain Plasticity Following Vision Loss","Neurobehavioral Effects of Visual Assistive Technologies","SenSubMRI","Inclusion Criteria:\n\n1. 8-85 years old for blind individuals; or 18-85 years old for sighted controls.\n2. (a) Blind due to ocular impairment (documented visual acuity of light perception or worse) in both eyes, or (b) sighted healthy adult controls with corrected visual acuity of 20\u002F40 or better and with no known vision disorders.\n3. Able to hear the Informed Consent Form being read out to him or her, to understand it, and sign the Informed Consent Form.\n4. Able to undergo functional neuroimaging tests.\n5. Able to walk and stand independently.\n6. Able to understand and remember the training protocols involved in the research study.\n7. Willing and able to use the provided sensory substitution system to solve simple visual tasks.\n8. Willing and able to complete simple tactile or auditory tasks.\n9. Able to communicate by telephone and\u002For computer with research staff.\n\nExclusion Criteria:\n\n1. Prior use with the sensory substitution device under investigation. This applies to both the auditory and tactile stimulators.\n2. Presence of any foreign metal in the body, except for dental fillings (will need to be pre-screened by a radiologist prior to signing the informed consent and enrollment).\n3. Pregnant or breastfeeding by self-report or urine test.\n4. Is a prisoner or has any required movements legally restricted.\n5. Unwilling or unable to adhere to all study requirements, including completion of the training period and any evaluation tests.\n6. Implanted electrical medical devices such as pacemakers.\n7. Claustrophobia that would prevent functional neuroimaging.\n8. Obesity preventing placement in the MRI scanner.\n9. No known neurological disorders or any medical condition that can possibly lead to emergency medical care (e.g., history of seizures, family history of epilepsy, stroke, severe headaches, use of medication for neurological or psychiatric conditions).\n10. Documented or suspected brain damage resulting in significant cognitive or sensory impairment (e.g., traumatic brain injury).",true,"ALL","8 Years","85 Years",{"count":109,"type":110},200,"ESTIMATED","INTERVENTIONAL",[113],"NA","The goal of this clinical investigation is to learn how the brain responds when visual information is converted into patterns of sound or touch in blind and sighted participants. The main questions it aims to answer are:\n\n* Does converting visual information into sound or touch patterns change visual performance in the blind or blindfolded?\n* How does the brain adapt to different kinds of sensory information?\n\nResearchers will use brain imaging and simple performance tasks to see how people process and learn from this type of converted sensory input. The investigators will compare how individuals with and without long-term vision loss respond to these signals.\n\nParticipants will:\n\n* Learn to use technologies to assist in visual information conversion into sound or touch patterns every day for 5 weeks;\n* Visit the brain imaging center 3 times for brain scans and behavioral tests.",[116],"Blindness",[116,118,119,120,121,122,123,124],"Visual cortex","Sensory substitution","Assistive technology","Magnetic resonance imaging","Brain","Sound","Touch","NOT_YET_RECRUITING","2026-03-01",{"date":128,"type":129},"2026-03-05","ACTUAL",{"date":131,"type":110},"2026-06-01",{"date":133,"type":110},"2030-08-31",{"name":5,"class":6},2]