[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555643":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":41,"responsibleParty":55,"collaborators":26,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":26,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":26,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Zagazig University","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sequential GNA Followed by GAE","EXPERIMENTAL","Participants in this group will undergo genicular nerve ablation (GNA), followed by geniculate artery embolization (GAE) one month later. The GNA procedure will target the genicular nerves responsible for knee pain, and the GAE procedure will target the geniculate arteries to reduce inflammation and pain. The sequence is designed to optimize pain relief and functional outcomes.",[13],"Procedure: GNA followed by GAE",{"label":15,"type":16,"description":17,"interventionNames":18},"GAE Alone","ACTIVE_COMPARATOR","Participants in this group will receive geniculate artery embolization (GAE) alone, without prior genicular nerve ablation (GNA). The GAE procedure will target the geniculate arteries to reduce inflammation and pain. This arm serves as the control to compare the effectiveness and safety of the sequential GNA followed by GAE intervention.",[19],"Procedure: GAE alone",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","GNA followed by GAE","Participants in the experimental arm will undergo genicular nerve ablation (GNA), a minimally invasive procedure targeting the genicular nerves to interrupt pain transmission. One month after undergoing GNA, participants will receive geniculate artery embolization (GAE), which targets the geniculate arteries to reduce inflammation and pain.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"GAE alone","Participants in the active comparator arm will receive geniculate artery embolization (GAE) alone, a minimally invasive procedure targeting the geniculate arteries to reduce inflammation and pain, without prior genicular nerve ablation (GNA).",[15],[32],{"name":33,"affiliation":34,"role":35},"Ahmed A Bessar, MD, PhD","Assistant Professor of Diagnostic and Interventional Radiology, Zagazig Uni.","PRINCIPAL_INVESTIGATOR",[37],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","+201000089595","Ahmedawadbessar@gmail.com",[42],{"facility":43,"status":44,"city":45,"state":26,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":26},"Zagazig University, Faculty of Medicine","RECRUITING","Zagazig","44519","Egypt","EG",{"type":50,"coordinates":51},"Point",[52,53],31.502,30.58768,{"lat":53,"lon":52},{"type":35,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ahmed Awad Bessar","Assistant Professor of Diagnostic and Interventional Radiology","100555643","sequential-genicular-nerve-ablation-prior-to-geniculate-artery-embolization-in-knee-pain-100555643",false,"NCT06514755","Sequential Genicular Nerve Ablation Prior to Geniculate Artery Embolization in Knee Pain","Sequential Genicular Nerve Ablation Prior to Geniculate Artery Embolization in Knee Pain Management: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 to 80 years.\n* Diagnosed with chronic knee pain refractory to conservative treatment.\n* Able to provide informed consent.\n* Agree to follow the study procedures and attend follow-up visits.\n\nExclusion Criteria:\n\n* Contraindications to GNA or GAE procedures (e.g., allergy to local anesthetics, active infection at the procedure site).\n* Recent knee surgery within the last six months.\n* Severe comorbid conditions that may interfere with the study outcomes (e.g., rheumatoid arthritis, other severe autoimmune diseases).\n* Current participation in another clinical trial that could interfere with the outcomes of this study.","ALL","18 Years","80 Years",{"count":69,"type":70},60,"ESTIMATED","INTERVENTIONAL",[73],"NA","The goal of this clinical trial is to evaluate whether performing genicular nerve ablation (GNA) before geniculate artery embolization (GAE) improves pain relief and knee function in patients with chronic knee pain. The main questions it aims to answer are:\n\n* Does performing GNA prior to GAE enhance pain relief, as measured by the Visual Analog Scale (VAS), at 3 months post-procedure?\n* Does the sequential approach improve knee function as assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)?\n\nStudy investigators will compare two groups to see if the sequential approach (GNA followed by GAE) provides better outcomes compared to GAE alone.\n\nParticipants will:\n\n* Undergo either sequential GNA followed by GAE or GAE alone\n* Have their knee pain and function assessed at baseline, 1 month, 3 months, and 6 months post-procedure\n* Complete a structured patient satisfaction questionnaire (PSQ) at 3 months post-procedure\n* Be monitored for procedure-related adverse events up to 6 months post-procedure,",[76,77],"Chronic Knee Pain","Osteoarthritis",[79,80,81,82],"Genicular Nerve Ablation","Geniculate Artery Embolization","Knee Function","Patient Satisfaction","2024-09-29",{"date":85,"type":86},"2024-10-01","ACTUAL",{"date":83,"type":86},{"date":89,"type":70},"2025-04-30",{"name":5,"class":6},1]