[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632777":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":12,"locations":18,"responsibleParty":31,"collaborators":7,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":7,"eligibilityCriteria":41,"healthyVolunteers":37,"sex":42,"minAge":43,"maxAge":7,"enrollmentInfo":44,"targetDuration":7,"studyType":47,"phases":7,"briefSummary":48,"conditions":49,"keywords":7,"overallStatus":50,"whyStopped":7,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":60},{"fullName":5,"class":6},"Istinye University","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"Enteral Nutrition Intolerance (EFI)","The study investigates the development of EFI, characterized by symptoms like increased gastric residual volume, vomiting, and abdominal distension.",[13],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"ilke dolğun","CONTACT","05555485632","ilkeser2004@gmail.com",[19],{"facility":20,"status":7,"city":21,"state":22,"zip":23,"country":24,"countryCode":7,"cosmosGeoPoint":25,"geoPoint":30,"contacts":7},"Istinye Üniversity","Istanbul","Merkez Mahallesi","34250","Turkey (Türkiye)",{"type":26,"coordinates":27},"Point",[28,29],28.94966,41.01384,{"lat":29,"lon":28},{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","İlke Dolgun","Assoc Prof","100632777","serum-bicarbonate-and-enteral-feeding-intolerance-in-adult-icu-a-prospective-clinical-trial-100632777",false,"NCT07518095","Serum Bicarbonate and Enteral Feeding Intolerance in Adult ICU: A Prospective Clinical Trial","Serum Bicarbonate and Enteral Feeding Intolerance in Adult ICU Patients: A Prospective Clinical Trial","Inclusion Criteria:\n\n* Adult patients aged 18 and older.\n* Patients started on enteral nutrition (EN) within the first 48 hours of their intensive care unit admission.\n* Patients predicted to remain in the intensive care unit for at least 72 hours.\n* Patients (or their legal representatives) who have provided consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients under the age of 18.Individuals who are currently pregnant or breastfeeding.\n* Patients with gastrointestinal (GI) perforation, active GI bleeding, or mechanical bowel obstruction.\n* Patients who have undergone major abdominal surgery (e.g., esophagectomy, gastrectomy) within the last month.\n* Patients receiving total parenteral nutrition (TPN) or those who are only fed orally.\n* Patients requiring specialized enteral formulas (e.g., diabetic, renal, immunomodulatory, elemental, or semi-elemental) due to clinical necessity.\n* Patients with a known diagnosis of diabetes or those with HbA1c \\>6.5 requiring a diabetic enteral formula.\n* Patients with terminal-stage malignancy or those requiring specific enteral nutrition protocols.\n* Patients with advanced (Child-Pugh C) liver failure.\n* Patients with chronic kidney failure requiring dialysis.\n* Patients with diabetic ketoacidosis, severe metabolic asidozis, or those requiring initial bicarbonate replacement.\n* Patients who are brain dead or in the palliative care stage.","ALL","18 Years",{"count":45,"type":46},70,"ESTIMATED","OBSERVATIONAL","This prospective, observational study evaluates whether serum bicarbonate HCO3 levels can predict enteral nutrition intolerance (EFI) in adult ICU patients.Objective: To determine if lower HCO3 levels correlate with the development of EFI.Design: A 12-month study involving 70 participants at Sultangazi Haseki Training and Research Hospital.Methodology: Patients starting enteral nutrition within 48 hours of admission will be monitored for 72 hours. Daily HCo3 pH, and lactate levels will be recorded from routine morning blood draws.Hypothesis: Lower bicarbonate levels are an independent predictor of EFI development in critically ill patients.",[10],"NOT_YET_RECRUITING","2026-04-01",{"date":53,"type":54},"2026-04-08","ACTUAL",{"date":56,"type":46},"2026-04-15",{"date":58,"type":46},"2027-01-15",{"name":5,"class":6},1]