[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620461":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":10,"responsibleParty":22,"collaborators":10,"id":25,"slug":26,"hasResults":27,"nctId":28,"briefTitle":29,"officialTitle":30,"acronym":10,"eligibilityCriteria":31,"healthyVolunteers":32,"sex":33,"minAge":34,"maxAge":35,"enrollmentInfo":36,"targetDuration":39,"studyType":40,"phases":10,"briefSummary":41,"conditions":42,"keywords":44,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":10},{"fullName":5,"class":6},"Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Lactating Pregnant Women (First Trimester)",null,"Pregnant women who conceived during the lactation period and are in the first trimester of pregnancy. Maternal serum progesterone levels will be measured at enrollment. Participants will be prospectively followed to evaluate the occurrence of threatened abortion, defined as first-trimester vaginal bleeding with a viable intrauterine pregnancy. This is a prospective observational cohort study, and no interventions are assigned.",[13],{"name":14,"affiliation":5,"role":15},"Burak D. Aydoğdu, M.D.","PRINCIPAL_INVESTIGATOR",[17],{"name":18,"role":19,"phone":20,"phoneExt":10,"email":21},"Burak D Aydoğdu, M.D.","CONTACT","+90 539 618 2228","burakd.1992@hotmail.com",{"type":15,"investigatorFullName":23,"investigatorTitle":24,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Burak Deniz Aydoğdu","M.D.","100620461","serum-progesterone-and-threatened-abortion-during-lactation-100620461",false,"NCT07357922","Serum Progesterone and Threatened Abortion During Lactation","Association Between Maternal Serum Progesterone Levels and Threatened Abortion in Lactating Pregnant Women","Inclusion Criteria:\n\n* Female participants aged 18 to 50 years.\n* Pregnant women who conceived during the lactation period.\n* Singleton pregnancy.\n* First-trimester pregnancy.\n* Availability of first-trimester serum progesterone measurement obtained as part of routine antenatal care.\n* Ongoing follow-up at the participating hospitals.\n\nExclusion Criteria:\n\n* Age under 18 years or over 50 years.\n* Multiple pregnancies.\n* Known chronic medical diseases.\n* Use of progesterone supplementation before serum progesterone measurement.\n* Missing or incomplete clinical or laboratory data.",true,"FEMALE","18 Years","50 Years",{"count":37,"type":38},150,"ESTIMATED","4 Months","OBSERVATIONAL","This study aims to evaluate the effect of first-trimester maternal serum progesterone levels on threatened abortion in women who conceive during the lactation period. Serum progesterone concentrations will be measured in lactating pregnant women during the first trimester, and their association with the etiology of threatened abortion will be analyzed.\n\nThreatened abortion is defined as vaginal bleeding occurring in the first trimester of pregnancy and represents a risk for early pregnancy loss. Previous studies have shown that serum progesterone levels may be lower in cases of threatened abortion compared to healthy pregnancies and play an essential role in predicting miscarriage risk. Serum progesterone is therefore considered a useful biomarker for assessing pregnancy viability and prognosis.\n\nDuring lactation, progesterone levels may vary depending on breastfeeding duration and maternal hormonal status, and generally remain low, similar to follicular-phase levels in non-pregnant women. However, normal reference values during lactation are not well established. This study aims to contribute new data to the limited literature on the relationship between lactation, serum progesterone levels, and threatened abortion, and to provide insights that may help improve early pregnancy loss prevention strategies.",[43],"Threatened Abortion",[45,43,46],"Serum Progesterone Levels","Lactation During Pregnancy","NOT_YET_RECRUITING","2026-01-23",{"date":50,"type":51},"2026-01-26","ACTUAL",{"date":53,"type":38},"2026-01-01",{"date":55,"type":38},"2028-01-01",{"name":5,"class":6}]