[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638726":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":58,"collaborators":25,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":25,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Ataturk University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Propofol Group","EXPERIMENTAL","Patients in this group will receive propofol-based total intravenous anesthesia (TIVA) during elective lumbar instrumentation surgery. Anesthesia will be maintained with propofol infusion (4-10 mg\u002Fkg\u002Fh) combined with remifentanil infusion under BIS monitoring.",[13],"Drug: Propofol (Astra-Zeneca)",{"label":15,"type":10,"description":16,"interventionNames":17},"Sevoflurane Group","Patients in this group will receive sevoflurane-based inhalational anesthesia during elective lumbar instrumentation surgery. Anesthesia will be maintained with sevoflurane (1-1.3 MAC) combined with remifentanil infusion under BIS monitoring.",[18],"Drug: Sevoflurane",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Propofol (Astra-Zeneca)","Propofol-based total intravenous anesthesia (TIVA) administered via continuous infusion (4-10 mg\u002Fkg\u002Fh) in combination with remifentanil for maintenance of anesthesia under BIS monitoring during elective lumbar instrumentation surgery.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Sevoflurane","Sevoflurane-based inhalational anesthesia administered at 1-1.3 MAC in combination with remifentanil infusion for maintenance of anesthesia under BIS monitoring during elective lumbar instrumentation surgery.",[15],[31],{"name":32,"affiliation":33,"role":34},"Ayşe Ceren Hilal Güven, assistant doctor","Ataturk University Department of Anesthesiology and Reanimation","STUDY_CHAIR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Mehmet Akif Yilmaz, Doctor","CONTACT","+905346533539","mehmetakifyilmaz025@gmail.com",{"name":32,"role":38,"phone":42,"phoneExt":25,"email":43},"554-112-25-81","achg1995@gmail.com",[45],{"facility":5,"status":46,"city":47,"state":25,"zip":48,"country":49,"countryCode":25,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Erzurum","25000","Turkey (Türkiye)",{"type":51,"coordinates":52},"Point",[53,54],41.27694,39.90861,{"lat":54,"lon":53},[57],{"name":32,"role":38,"phone":42,"phoneExt":25,"email":43},{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Mehmet Akif Yilmaz","Principal Investigator","100638726","sevoflurane-vs-propofol-anesthesia-in-obese-patients-undergoing-lumbar-surgery-100638726",false,"NCT07611240","Sevoflurane vs Propofol Anesthesia in Obese Patients Undergoing Lumbar Surgery","Comparison of the Immunomodulatory Effects of Sevoflurane and Propofol Anesthesia on Pentraxin-3 and Serum Amyloid A Levels in Obese Patients Undergoing Lumbar Instrumentation Surgery","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* Patients scheduled for elective lumbar instrumentation surgery\n* Body mass index between 30 and 34.9 kg\u002Fm²\n* Patients who provided written informed consent\n\nExclusion Criteria:\n\n* Known allergy to inhalational or intravenous anesthetic agents\n* Acute or chronic infectious disease\n* Autoimmune disease or immunodeficiency\n* Surgery within the last 3 months\n* Chronic anti-inflammatory or immunomodulatory drug use\n* Morbid obesity, defined as BMI \\>35 kg\u002Fm²\n* History of malignancy or active cancer treatment\n* Renal failure, defined as GFR \\\u003C60 mL\u002Fmin\n* Liver failure, defined as AST or ALT greater than 2 times the upper limit of normal\n* Diabetes mellitus, metabolic syndrome, or insulin resistance\n* Pregnancy or lactation\n* Neurological disease, including epilepsy, multiple sclerosis, or Parkinson's disease\n* Alcohol or substance abuse\n* Inability to comply with the study protocol or provide informed consent\n* Known allergy to study drugs (propofol, sevoflurane, remifentanil)\n* Emergency surgery","ALL","18 Years","65 Years",{"count":73,"type":74},70,"ESTIMATED","INTERVENTIONAL",[77],"NA","This randomized, single-center, single-masked clinical trial aims to compare the immunomodulatory effects of sevoflurane-based inhalational anesthesia and propofol-based total intravenous anesthesia in obese patients undergoing elective lumbar instrumentation surgery. Seventy patients will be randomized into two groups: a propofol group and a sevoflurane group. Blood samples will be collected preoperatively, at postoperative 6 hours, and at postoperative 24 hours. Pentraxin-3 and serum amyloid A levels will be evaluated as primary inflammatory biomarkers together with IL-6, TNF-α, CRP, glucose, and complete blood count parameters.",[80,81],"Obesity & Overweight","Lumbar Spine Surgery",[83,27,84,85,86,87,88,89],"Propofol","Pentraxin-3","Serum Amyloid A","Immunomodulation","Total Intravenous Anesthesia","Volatile Anesthesia","Inflammatory Response","2026-05-20",{"date":92,"type":93},"2026-05-28","ACTUAL",{"date":95,"type":93},"2025-06-15",{"date":97,"type":74},"2026-06-16",{"name":5,"class":6},1]