[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597736":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":37,"locations":43,"responsibleParty":68,"collaborators":30,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":30,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":30,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":30,"overallStatus":45,"whyStopped":30,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Tanta University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Propofol group","ACTIVE_COMPARATOR","Patients' anesthesia will be maintained by manually adjusted propofol infusion at a rate of 100-250 mic\u002Fkg\u002Fmin for bispectral index (BIS) maintained between 40-60.",[13],"Drug: Propofol",{"label":15,"type":16,"description":17,"interventionNames":18},"Sevoflurane plus lidocaine infusion group","EXPERIMENTAL","Sevoflurane with monitored anesthesia care (MAC) adjusted to maintain bispectral index (BIS) between 40-60 plus intravenous lidocaine infusion given as 2mg \u002Fkg IV bolus before induction then intraoperative infusion by a rate of 2 mg\u002Fkg\u002Fh until the end of surgery.",[19],"Drug: Sevoflurane plus lidocaine infusion",{"label":21,"type":16,"description":22,"interventionNames":23},"Sevoflurane group","Patients will receive sevoflurane with monitored anesthesia care (MAC) adjusted to maintain bispectral index (BIS) between 40-60.",[24],"Drug: Sevoflurane",[26,31,34],{"type":27,"name":28,"description":11,"armGroupLabels":29,"otherNames":30},"DRUG","Propofol",[9],null,{"type":27,"name":32,"description":17,"armGroupLabels":33,"otherNames":30},"Sevoflurane plus lidocaine infusion",[15],{"type":27,"name":35,"description":22,"armGroupLabels":36,"otherNames":30},"Sevoflurane",[21],[38],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},"Eman A Elrefaey, Master","CONTACT","00201008031402","eman.elrefaey@med.tanta.edu.eg",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Tanta","El-Gharbia","31527","Egypt","EG",{"type":52,"coordinates":53},"Point",[54,55],31.00192,30.78847,{"lat":55,"lon":54},[58,59,62,64,66],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},{"name":60,"role":61,"phone":30,"phoneExt":30,"email":30},"Hesham M Marof, MD","SUB_INVESTIGATOR",{"name":63,"role":61,"phone":30,"phoneExt":30,"email":30},"Ashraf E Elzeftawy, MD",{"name":65,"role":61,"phone":30,"phoneExt":30,"email":30},"Mohammed S Abdelghafar, MD",{"name":67,"role":61,"phone":30,"phoneExt":30,"email":30},"Osama M Rehab, MD",{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Eman Ali Abd-Elsamea Elrefaey","Assistant Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.","100597736","sevoflurane-with-or-without-intravenous-lidocaine-infusion-versus-propofol-anesthesia-on-intracranial-pressure-and-cerebral-oxygenation-during-laparoscopic-hysterectomy-100597736",false,"NCT07062367","Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy","Effect of Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy: A Randomized Controlled Study","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* American Society of Anesthesiologists (ASA) physical status I and Ⅱ.\n* Body mass index (BMI) ≤35.\n* Females scheduled for laparoscopic hysterectomy.\n\nExclusion Criteria:\n\n* Patients' refusal to participate in the study.\n* Hypersensitivity and allergy to drugs of the study.\n* Contraindication for optic nerve sheath diameter assessment. E.g., patient with pre-existing ophthalmic diseases, a history of ophthalmic surgery\n* Any central nervous system or cardiovascular disease, severe hepatic or renal impairment\n* Intraoperative circumstances, such as inability to perform optic nerve sheath diameter or conversion to open surgery\n* If peak inspiratory pressure (PIP) exceeds 35.","FEMALE","18 Years","65 Years",{"count":83,"type":84},90,"ESTIMATED","INTERVENTIONAL",[87],"NA","This study will be conducted to evaluate the effects of different anesthetic modalities \\[sevoflurane with or without intraoperative lidocaine infusion and Propofol total intravenous anesthesia (TIVA)\\] on intracranial pressure (ICP) and cerebral oxygenation assessed by non-invasive methods during laparoscopic hysterectomy (LH).",[35,90,28,91,92,93],"Lidocaine","Intracranial Pressure","Cerebral Oxygenation","Laparoscopic Hysterectomy","2025-07-02",{"date":96,"type":97},"2025-07-14","ACTUAL",{"date":99,"type":97},"2025-02-01",{"date":101,"type":84},"2027-02-01",{"name":5,"class":6},1]