[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521973":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":24,"locations":29,"responsibleParty":52,"collaborators":7,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":7,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":7,"studyType":68,"phases":7,"briefSummary":69,"conditions":70,"keywords":7,"overallStatus":31,"whyStopped":7,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Korea University Anam Hospital","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Adenosine stress echocardiography","Transthoracic echocardiographic assessments will be performed using an ultrasound device (Vivid E95, General Electric Healthcare, Liestal, Switzerland). Color Doppler flow of the distal left anterior descending artery was examined from the modified apical four-chamber view of the anterior interventricular groove. Pulsed-wave Doppler registered blood flow velocity patterns using a sample volume (2-3.0 mm) placed on the color signal. The ultrasound beam was aligned parallel to the vessel flow. The velocity scale of color Doppler was set to 0.21 m\u002Fs. Coronary flow Doppler images were acquired at baseline and at 1, 2, and 3 min after adenosine infusion in the same part of the artery. Anti-anginal medications, including calcium channel blockers, were discontinued before the study.",[14,17,20,22],{"name":15,"affiliation":5,"role":16},"Seong-Mi Park, PhD","PRINCIPAL_INVESTIGATOR",{"name":18,"affiliation":5,"role":19},"Mi-Na Kim, PhD","STUDY_CHAIR",{"name":21,"affiliation":5,"role":19},"Dong-Hyuk Cho, PhD",{"name":23,"affiliation":5,"role":19},"So Ree Kim, PhD",[25],{"name":23,"role":26,"phone":27,"phoneExt":7,"email":28},"CONTACT","82-10-9453-4810","soree8826kim@gmail.com",[30],{"facility":5,"status":31,"city":32,"state":7,"zip":33,"country":34,"countryCode":7,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"RECRUITING","Seoul","02841","South Korea",{"type":36,"coordinates":37},"Point",[38,39],126.9784,37.566,{"lat":39,"lon":38},[42,43,45,48,50],{"name":23,"role":26,"phone":7,"phoneExt":7,"email":28},{"name":44,"role":16,"phone":7,"phoneExt":7,"email":7},"Seong-Mi Park",{"name":46,"role":47,"phone":7,"phoneExt":7,"email":7},"Mi-Na Kim","SUB_INVESTIGATOR",{"name":49,"role":47,"phone":7,"phoneExt":7,"email":7},"Dong-Hyuk Cho",{"name":51,"role":47,"phone":7,"phoneExt":7,"email":7},"So Ree Kim",{"type":16,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Seong-Mi Park, M.D. Ph.D.","Professor","100521973","sex-difference-of-coronary-microvascular-dysfunction-in-patients-with-non-obstructive-coronary-artery-disease-100521973",false,"NCT06076551","Sex Difference of Coronary Microvascular Dysfunction in Patients With Non-obstructive Coronary Artery Disease","Sex Difference of Coronary Microvascular Dysfunction Evaluated by Coronary Flow Reserve in Patients With Non-obstructive Coronary Artery Disease","Inclusion Criteria:\n\n* Typical\u002Fatypical chest pain or ischemic symptoms including dyspnea\n* No significant coronary artery stenosis (\\\u003C50% stenosis) in coronary angiography or computed tomography\n\nExclusion Criteria:\n\n* ≥ Moderate valvular heart disease\n* Congenital heart disease\n* Chronic renal failure (estimated glomerular filtration rate \\\u003C30 ml\u002Fmin\u002F1.73m2) or end-stage renal failure undergoing hemodialysis or peritoneal dialysis\n* Asthma, chronic obstructive pulmonary disease and primary pulmonary hypertension\n* Receiving anticancer drugs\n* Vasculitis associated with autoimmune diseases\n* Atrioventricular block with more than second degrees, symptomatic bradycardia, cryo-node failure syndrome, Wolff-Parkinson-White (WPW) patients","ALL","20 Years","80 Years",{"count":66,"type":67},300,"ESTIMATED","OBSERVATIONAL","Sex difference of coronary microvascular dysfunction evaluated by coronary flow reserve will be assessed in patients with non-obstructive coronary artery disease",[71],"Microvascular Angina","2025-03-24",{"date":74,"type":75},"2025-03-26","ACTUAL",{"date":77,"type":75},"2018-02-01",{"date":79,"type":67},"2025-12-31",{"name":5,"class":6},1]